Disease · MONDO_0017364

POEMS syndrome

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. POEMS syndrome. Diseases, record MONDO_0017364. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0017364

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: POEMS syndrome; Open Targets
Open Targets ID: MONDO_0017364; Open Targets
Other names: Crow-Fukase syndrome, PEP syndrome, POEMS syndrome (disorder), Takatsuki syndrome, osteosclerotic myeloma, polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome; Open Targets
Disease Ontology: DOID:14039; Disease Ontology
MeSH: D016878; MeSH
NCI Thesaurus: C80303; NCI Thesaurus
Orphanet: ORPHA:2905; Orphanet
Highest stage of its drugs: Phase 2, for 12 of its 13 drugs, from ClinicalTrials.gov; Open Targets

Drugs13

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DEXAMETHASONE	CHEMBL384467	Small molecule	Phase 2	ClinicalTrials.gov	6	6	6	Drugs and targets
LENALIDOMIDE	CHEMBL848	Small molecule	Phase 2	ClinicalTrials.gov	6	6	6	Drugs and targets
BORTEZOMIB	CHEMBL325041	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
CARMUSTINE	CHEMBL513	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
CISPLATIN	CHEMBL11359	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
CYCLOPHOSPHAMIDE	CHEMBL1200796	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
DARATUMUMAB	CHEMBL1743007	Antibody	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
DOXORUBICIN	CHEMBL53463	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ETOPOSIDE	CHEMBL44657	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
GEMCITABINE	CHEMBL888	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 13

See all 13 drugs

Targets61

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADRM1	26S proteasome	2	26S proteasome inhibitor	Phase 2	https://conductscience.org/library/genes/11047	Drugs and targets
CRBN	CRL4(CRBN) E3 ubiquitin ligase	2	CRL4(CRBN) E3 ubiquitin ligase inhibitor; CRL4(CRBN) E3 ubiquitin ligase modulator	Phase 2	https://conductscience.org/library/genes/51185	Drugs and targets
CUL4A	CRL4(CRBN) E3 ubiquitin ligase	2	CRL4(CRBN) E3 ubiquitin ligase inhibitor; CRL4(CRBN) E3 ubiquitin ligase modulator	Phase 2	https://conductscience.org/library/genes/8451	Drugs and targets
DDB1	CRL4(CRBN) E3 ubiquitin ligase	2	CRL4(CRBN) E3 ubiquitin ligase inhibitor; CRL4(CRBN) E3 ubiquitin ligase modulator	Phase 2	https://conductscience.org/library/genes/1642	Drugs and targets
PSMA1	26S proteasome	2	26S proteasome inhibitor	Phase 2	https://conductscience.org/library/genes/5682	Drugs and targets
PSMA2	26S proteasome	2	26S proteasome inhibitor	Phase 2	https://conductscience.org/library/genes/5683	Drugs and targets
PSMA3	26S proteasome	2	26S proteasome inhibitor	Phase 2	https://conductscience.org/library/genes/5684	Drugs and targets
PSMA4	26S proteasome	2	26S proteasome inhibitor	Phase 2	https://conductscience.org/library/genes/5685	Drugs and targets
PSMA5	26S proteasome	2	26S proteasome inhibitor	Phase 2	https://conductscience.org/library/genes/5686	Drugs and targets
PSMA6	26S proteasome	2	26S proteasome inhibitor	Phase 2	https://conductscience.org/library/genes/5687	Drugs and targets

1 to 10 of 61

See all 61 targets

Trials7

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01548573	Tandem Auto Transplantation in Myeloma Patients With <12 Months of Prior Treatment	Phase 2	19	2017-06-14	Multiple Myeloma	BORTEZOMIB, CARMUSTINE, CISPLATIN, CYCLOPHOSPHAMIDE, DEXAMETHASONE, DOXORUBICIN, ETOPOSIDE, GEMCITABINE, MELPHALAN, THALIDOMIDE	Its record names the disease	ClinicalTrials.gov
NCT04396496	Treatment of POEMS Syndrome With Daratumumab	Phase 2	2	2023-11-13	POEMS Syndrome	DARATUMUMAB, LENALIDOMIDE	Its record names the disease	ClinicalTrials.gov
NCT01639898	POEMS Syndrome Treatment With Lenalidomide	Phase 2	51		POEMS Syndrome	DEXAMETHASONE, LENALIDOMIDE	Its record names the disease	ClinicalTrials.gov
NCT01816620	Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS Syndrome	Phase 2	41		POEMS Syndrome	DEXAMETHASONE, LENALIDOMIDE	Its record names the disease	ClinicalTrials.gov
NCT02921893	Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome	Early phase 1	21		Plasmacytoma, POEMS Syndrome	DEXAMETHASONE, IXAZOMIB CITRATE, LENALIDOMIDE	Its record names the disease	ClinicalTrials.gov
NCT00971685	The Treatment of Lenalidomide in Patients With POEMS Syndrome	Phase 2	16		POEMS Syndrome	DEXAMETHASONE, LENALIDOMIDE	Its record names the disease	ClinicalTrials.gov
NCT02193698	Efficacy and Safety of Lenalidomide as a Treatment for Recurrent or Refractory POEMS Syndrome Trial	Phase 2	5		POEMS Syndrome	DEXAMETHASONE, LENALIDOMIDE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials3

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
34025681	DERIVED	1	PubMed
32429967	DERIVED	1	PubMed
29603764	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0017364

GET https://conductscience.org/api/diseases/v1/MONDO_0017364/targets?page=2

API reference For AI assistants