Disease · MONDO_0017376

reactive arthritis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. reactive arthritis. Diseases, record MONDO_0017376. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0017376

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: reactive arthritis; Open Targets
Open Targets ID: MONDO_0017376; Open Targets
Other names: Arthritis, Reactive, Fiessinger Leroy Reiter syndrome, Fiessinger-Leroy disease, Post-bacterial arthropathy, Reiter disease, Reiter syndrome, Reiter's disease, Reiter's syndrome, arthritis urethritica, polyarthritis enterica, postdysenteric arthropathy, venereal arthritis; Open Targets
Disease Ontology: DOID:6196; Disease Ontology
MeSH: D016918; MeSH
NCI Thesaurus: C128332; NCI Thesaurus
Orphanet: ORPHA:29207; Orphanet
Highest stage of its drugs: Phase 3, for 3 of its 8 drugs, from ClinicalTrials.gov; Open Targets

Drugs8

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
AZITHROMYCIN	CHEMBL529	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
DOXYCYCLINE	CHEMBL1200699	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
RIFAMPIN	CHEMBL374478	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
INFLIXIMAB	CHEMBL1201581	Antibody	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
INTERFERON GAMMA-1B	CHEMBL1201564	Protein	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
CELECOXIB	CHEMBL118	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
OFLOXACIN	CHEMBL4	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
ROXITHROMYCIN	CHEMBL1214185	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets8

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
IFNGR1	Interferon gamma receptor	1	Interferon gamma receptor agonist	Phase 2	https://conductscience.org/library/genes/3459	Drugs and targets
IFNGR2	Interferon gamma receptor	1	Interferon gamma receptor agonist	Phase 2	https://conductscience.org/library/genes/3460	Drugs and targets
MMP1	Interstitial collagenase	1	Matrix metalloproteinase-1 inhibitor	Phase 3	https://conductscience.org/library/genes/4312	Drugs and targets
MMP13	Collagenase 3	1	Matrix metalloproteinase 13 inhibitor	Phase 3	https://conductscience.org/library/genes/4322	Drugs and targets
MMP7	Matrilysin	1	Matrix metalloproteinase 7 inhibitor	Phase 3	https://conductscience.org/library/genes/4316	Drugs and targets
MMP8	Neutrophil collagenase	1	Matrix metalloproteinase 8 inhibitor	Phase 3	https://conductscience.org/library/genes/4317	Drugs and targets
PTGS2	Prostaglandin G/H synthase 2	1	Cyclooxygenase-2 inhibitor	Unknown	https://conductscience.org/library/genes/5743	Drugs and targets
TNF	Tumor necrosis factor	1	TNF-alpha inhibitor	Phase 2	https://conductscience.org/library/genes/7124	Drugs and targets

Trials4

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00351273	Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria	Phase 3	42	2016-08-10	Arthritis, Reactive, Reiter Disease	AZITHROMYCIN, DOXYCYCLINE, RIFAMPIN	Its record names the disease	ClinicalTrials.gov
NCT05960864	Chinese Spondyloarthritis Inception Cohort (CESPIC)		1,000		Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA), Axial Psoriatic Arthritis (axPsA), Acute Anterior Uveitis (AAU), Crohn Disease (CD), Ulcerative Colitis (UC), Reactive Arthritis (ReA)	CELECOXIB	Its record names the disease	ClinicalTrials.gov
NCT00621387	Study of Long-Term Antibiotic Treatment in Reactive Arthritis	Not applicable	56		Reactive Arthritis	OFLOXACIN, ROXITHROMYCIN	Its record names the disease	ClinicalTrials.gov
NCT00244179	New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis	Phase 2	40		Reactive Arthritis	INFLIXIMAB, INTERFERON GAMMA-1B	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials5

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
21885496	RESULT	1	PubMed
21622969	RESULT	1	PubMed
20498207	RESULT	1	PubMed
19248087	RESULT	1	PubMed
20155838	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0017376

GET https://conductscience.org/api/diseases/v1/MONDO_0017376/drugs

API reference For AI assistants