Drug · CHEMBL441

THIOPENTAL

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. THIOPENTAL. Drugs and targets, record CHEMBL441. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL441

On this page

Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: THIOPENTAL; ChEMBL
ChEMBL ID: CHEMBL441; ChEMBL
Type: Small molecule; ChEMBL
Other names: Thiopental ciii; ChEMBL
Other form: THIOPENTAL SODIUM, CHEMBL738; Drugs and targets
DrugBank: DB00599; DrugBank
InChIKey: IUJDSEJGGMCXSG-UHFFFAOYSA-N; ChEMBL
Open Targets' highest stage: Approval, as Open Targets' drug record gives it; Open Targets

Targets16

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
GABRA1	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2554
GABRA2	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2555
GABRA3	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2556
GABRA4	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2557
GABRA5	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2558
GABRA6	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2559
GABRB1	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2560
GABRB2	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2561
GABRB3	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2562
GABRD	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2563

1 to 10 of 16Source ChEMBL

See all 16 targets

Diseases8

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
status epilepticus	Phase 3	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=EFO_0008526
Bradycardia	Unknown	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=HP_0001662
brain injury	Phase 3	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0043510
intracranial hypertension	Phase 3	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0006810
morbid obesity	Unknown	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0005139
prostate cancer	Unknown	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0008315
sedation	Phase 1/2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=EFO_0009868
septic shock	Phase 3	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=EFO_0006834

Source Open Targets

Trials19

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT00611767	GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence		73	2017-03-17	thiopental	Its name	ClinicalTrials.gov
NCT00767767	The Effect of Intravenous Anesthetics on Fear Learning and Memory		67	2017-04-10	thiopental	Its name	ClinicalTrials.gov
NCT00504894	Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes	Phase 4	60	2017-05-18	thiopental	Its name	ClinicalTrials.gov
NCT00265616	Treatment of Refractory Status Epilepticus	Phase 3	23	2013-04-04	thiopental	Its name	ClinicalTrials.gov
NCT00478907	Prevention of Complications of Eye Surgery	Phase 2	300		thiopental	Its name	ClinicalTrials.gov
NCT00379886	Comparison of Thiopental and Propofol as Anaesteticum During ECT		100		thiopental	Its name	ClinicalTrials.gov
NCT01318044	Thiopental Versus Propofol During Magnetic Resonance Imagining in Children: Something Old, Something New	Phase 1/2	100		thiopental	Its name	ClinicalTrials.gov
NCT07596095	Induction Agents in ECT: Effects on Seizure Duration, Quality, and Recovery		100		thiopental	Its name	ClinicalTrials.gov
NCT01140100	A Comparative Study of Depth of Anesthesia Monitored by Bispectral Index (BIS) Values	Phase 2	82		thiopental	Its name	ClinicalTrials.gov
NCT01930019	The Influence of Induction Anesthetic Agents on Serum Cortisol Concentration in Morbidly Obese Patients.		82		thiopental	Its name	ClinicalTrials.gov

1 to 10 of 19

See all 19 trials

Comparisons in its trials7

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Family History Negative for Alcoholism vs Family History Positive for Alcoholism: serious adverse events	0 of 49	0 of 24	73	NCT00611767	Trial comparisons
Propofol vs Thiopental/Pentobarbital: Refractory Status Epilepticus Controlled With First Course of Study Drug	6 of 14	2 of 9	23	NCT00265616	Trial comparisons
Propofol vs Thiopental/Pentobarbital: Patients With Hypotension Requiring Specific Treatment	7 of 14	5 of 9	23	NCT00265616	Trial comparisons
Propofol vs Thiopental/Pentobarbital: Patients With Propofol Infusion Syndrome	1 of 14	0 of 9	23	NCT00265616	Trial comparisons
Propofol vs Thiopental/Pentobarbital: Patients With Infectious Complications Requiring Specific Treatment	7 of 14	6 of 9	23	NCT00265616	Trial comparisons
Propofol vs Thiopental/Pentobarbital: Clinical Outcome at Day 21	5 of 14	3 of 9	23	NCT00265616	Trial comparisons
Propofol vs Thiopental/Pentobarbital: serious adverse events	1 of 14	1 of 9	23	NCT00265616	Trial comparisons

Papers from its trials8

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
25036373	RESULT	1	PubMed
24273687	RESULT	1	PubMed
22964265	RESULT	1	PubMed
20878265	RESULT	1	PubMed
15756405	RESULT	1	PubMed
30232735	DERIVED	1	PubMed
26174294	DERIVED	1	PubMed
18759980	DERIVED	1	PubMed

Tests in its trials2

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

Test	Trials naming it as an outcome	As a primary outcome	Source
Verbal Fluency	1	0	ConductCognition
Verbal Learning	1	0	ConductCognition

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL441

GET https://conductscience.org/api/drugs/v1/CHEMBL441/targets

API reference For AI assistants