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Disease · EFO_0000544

infection

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. infection. Diseases, record EFO_0000544. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0000544

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
infection
Open Targets
Open Targets ID
EFO_0000544
Open Targets
MeSH
D007239
MeSH
Highest stage of its drugs
Approval, for 147 of its 233 drugs, from ATC, DailyMed, EMA Human Drugs, FDA and PMDA
Open Targets

Drugs233

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
CEFTAZIDIMECHEMBL44354Small moleculeApprovalDailyMed231010Drugs and targets
MEROPENEMCHEMBL127Small moleculeApprovalDailyMed191010Drugs and targets
METRONIDAZOLECHEMBL137Small moleculeApprovalATC and DailyMed7166Drugs and targets
DAPTOMYCINCHEMBL387675Small moleculeApprovalDailyMed and PMDA855Drugs and targets
AMOXICILLINCHEMBL1082Small moleculeApprovalDailyMed17444Drugs and targets
CIPROFLOXACINCHEMBL8Small moleculeApprovalDailyMed2944Drugs and targets
AZTREONAMCHEMBL158Small moleculeApprovalDailyMed944Drugs and targets
TIGECYCLINECHEMBL376140Small moleculeApprovalDailyMed and PMDA644Drugs and targets
LEVOFLOXACINCHEMBL5315124Small moleculeApprovalDailyMed and PMDA9933Drugs and targets
ISOPROPYL ALCOHOLCHEMBL582Small moleculeApprovalDailyMed631Drugs and targets

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Targets45

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
LHCGRLutropin-choriogonadotropic hormone receptor3Luteinizing hormone/Choriogonadotropin receptor agonistPhase 1/2https://conductscience.org/library/genes/3973Drugs and targets
NR3C1Glucocorticoid receptor3Glucocorticoid receptor agonistApprovalhttps://conductscience.org/library/genes/2908Drugs and targets
CSF3RGranulocyte colony-stimulating factor receptor2Granulocyte colony stimulating factor receptor agonistApprovalhttps://conductscience.org/library/genes/1441Drugs and targets
DPEP1Dipeptidase 12Renal dipeptidase inhibitorApprovalhttps://conductscience.org/library/genes/1800Drugs and targets
GNRHRGonadotropin-releasing hormone receptor2Gonadotropin-releasing hormone receptor agonistPhase 1/2https://conductscience.org/library/genes/2798Drugs and targets
GRIN1Glutamate [NMDA] receptor2Glutamate [NMDA] receptor antagonistApprovalhttps://conductscience.org/library/genes/2902Drugs and targets
GRIN2AGlutamate [NMDA] receptor2Glutamate [NMDA] receptor antagonistApprovalhttps://conductscience.org/library/genes/2903Drugs and targets
GRIN2BGlutamate [NMDA] receptor2Glutamate [NMDA] receptor antagonistApprovalhttps://conductscience.org/library/genes/2904Drugs and targets
GRIN2CGlutamate [NMDA] receptor2Glutamate [NMDA] receptor antagonistApprovalhttps://conductscience.org/library/genes/2905Drugs and targets
GRIN2DGlutamate [NMDA] receptor2Glutamate [NMDA] receptor antagonistApprovalhttps://conductscience.org/library/genes/2906Drugs and targets

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Trials135

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 3 more are not shown, since the checks do not confirm them.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT00443599SPECS: Safe Pediatric Euglycemia in Cardiac SurgeryNot applicable9892014-03-10Heart Defects, Congenital, HyperglycemiaINSULIN HUMANOpen Targets' reading, confirmed by NLM's indexing of its papersClinicalTrials.gov
NCT03595553Comparison of Ridinilazole Versus Vancomycin Treatment for Clostridium Difficile InfectionPhase 37592023-03-03Clostridioides Difficile InfectionRIDINILAZOLE, VANCOMYCINOpen Targets' reading, confirmed by NLM's indexing of its papersClinicalTrials.gov
NCT03137173Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure InfectionsPhase 36792020-05-18Acute Bacterial Skin and Skin Structure InfectionsCEFTOBIPROLE MEDOCARIL SODIUMOpen Targets' reading, confirmed by NLM's indexing of its papersClinicalTrials.gov
NCT01844856Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Complicated Intra-abdominal InfectionsPhase 35412016-03-21Complicated Intra-abdominal InfectionsERAVACYCLINEOpen Targets' reading, confirmed by NLM's indexing of its papersClinicalTrials.gov
NCT02784704Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal InfectionsPhase 35002019-02-18Complicated Intra-abdominal Infections, Complicated AppendicitisERAVACYCLINE, MEROPENEMOpen Targets' reading, confirmed by NLM's indexing of its papersClinicalTrials.gov
NCT01644643Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant PathogensPhase 33452015-12-14Complicated Urinary Tract Infection, Complicated Intra-abdominal InfectionAVIBACTAM, CEFTAZIDIMEOpen Targets' reading, confirmed by NLM's indexing of its papersClinicalTrials.gov
NCT04218110Preoperative Skin Preparation Study to Evaluate the Antimicrobial Capabilities of Four Test SubstancesPhase 33292021-10-22Surgical Site InfectionCHLORHEXIDINE GLUCONATE, ISOPROPYL ALCOHOLIts record names the diseaseClinicalTrials.gov
NCT02469857Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue InfectionsPhase 32902021-10-05Necrotizing Soft Tissue Infections, Necrotizing Fasciitis, Fournier's GangreneBENZODEPA, RELTECIMODOpen Targets' reading of its recordClinicalTrials.gov
NCT03460704Trial in Non-cystic Fibrosis Bronchiectasis Patients With Chronic Lung Infections Treated With Colistimethate Sodium.Phase 32872023-12-29Non Cystic Fibrosis BronchiectasisCOLISTIMETHATE SODIUMIts record names the diseaseClinicalTrials.gov
NCT04042077Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site InfectionsPhase 32682021-10-29Surgical Site InfectionDELAFLOXACINOpen Targets' reading of its recordClinicalTrials.gov

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Comparisons in its trials82

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Insulin vs Usual Care: serious adverse events16 of 4905 of 490980NCT00443599Trial comparisons
Tight Glycemic Control vs Standard Care: Mortality at Hospital Discharge.11 of 49011 of 489979NCT00443599Trial comparisons
Tight Glycemic Control vs Standard Care: Mortality at 30 Days.5 of 4886 of 484972NCT00443599Trial comparisons
RIDINILAZOLE 200 MG vs VANCOMYCIN 125 MG: deaths from any cause26 of 37424 of 377751NCT03595553Trial comparisons
RIDINILAZOLE 200 MG vs VANCOMYCIN 125 MG: serious adverse events32 of 37430 of 377751NCT03595553Trial comparisons
Ceftobiprole Medocaril vs Vancomycin+Aztreonam: Early Clinical Response306 of 335303 of 344679NCT03137173Trial comparisons
Ceftobiprole Medocaril vs Vancomycin+Aztreonam: Investigator-assessed Clinical Success in the ITT Population302 of 335306 of 344679NCT03137173Trial comparisons
Ceftobiprole Medocaril vs Vancomycin+Aztreonam: deaths from any cause1 of 3343 of 342676NCT03137173Trial comparisons
Ceftobiprole Medocaril vs Vancomycin+Aztreonam: serious adverse events6 of 33412 of 342676NCT03137173Trial comparisons
Ceftobiprole Medocaril vs Vancomycin+Aztreonam: Investigator-assessed Clinical Success in the Clinically Evaluable (CE) Population277 of 283279 of 293576NCT03137173Trial comparisons

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Papers from its trials79

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
40233296RESULT1PubMed
37000942RESULT1PubMed
33191112RESULT1PubMed
32657946RESULT1PubMed
30561562RESULT2PubMed
29992286RESULT1PubMed
24740134RESULT1PubMed
23232039RESULT1PubMed
22957521RESULT1PubMed
22813936RESULT1PubMed

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Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_0000544

GET https://conductscience.org/api/diseases/v1/EFO_0000544/drugs?page=2

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