Disease · EFO_0004149

neuropathy

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. neuropathy. Diseases, record EFO_0004149. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0004149

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: neuropathy; Open Targets
Open Targets ID: EFO_0004149; Open Targets
Other names: Peripheral nerve damage, Peripheral neuritis, Peripheral neuropathy, peripheral nerve disorder; Open Targets
Disease Ontology: DOID:870; Disease Ontology
NCI Thesaurus: C4731; NCI Thesaurus
Highest stage of its drugs: Approval, for 1 of its 91 drugs, from TTD; Open Targets

Drugs91

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
MIROGABALIN	CHEMBL3545125	Small molecule	Approval	TTD	2	1	1	Drugs and targets
DULOXETINE	CHEMBL1175	Small molecule	Phase 3	ClinicalTrials.gov	10	10	10	Drugs and targets
CAPSAICIN	CHEMBL294199	Small molecule	Phase 3	ClinicalTrials.gov	7	7	7	Drugs and targets
GABAPENTIN	CHEMBL940	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
HUMAN IMMUNOGLOBULIN G	CHEMBL1201599		Phase 3	ClinicalTrials.gov	3	3	0	Drugs and targets
RUBOXISTAURIN	CHEMBL91829	Small molecule	Phase 3	ClinicalTrials.gov	3	3	1	Drugs and targets
AMITRIPTYLINE	CHEMBL629	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
AMITRIPTYLINE HYDROCHLORIDE	CHEMBL1200964	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
DIOSMIN	CHEMBL231884	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
KETAMINE	CHEMBL742	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets

1 to 10 of 91

See all 91 drugs

Targets152

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SLC6A2	Sodium-dependent noradrenaline transporter	5	Norepinephrine transporter inhibitor	Phase 3	https://conductscience.org/library/genes/6530	Drugs and targets
SLC6A4	Sodium-dependent serotonin transporter	5	Serotonin transporter inhibitor	Phase 3	https://conductscience.org/library/genes/6532	Drugs and targets
CACNA2D1	Voltage-dependent calcium channel subunit alpha-2/delta-1	3	Voltage-gated calcium channel alpha2/delta subunit 1 modulator; Voltage-gated calcium channel modulator	Approval	https://conductscience.org/library/genes/781	Drugs and targets
CACNA2D2	Voltage-dependent calcium channel subunit alpha-2/delta-2	3	Voltage-gated calcium channel alpha2/delta subunit 2 modulator; Voltage-gated calcium channel modulator	Approval	https://conductscience.org/library/genes/9254	Drugs and targets
GRIN1	Glutamate NMDA receptor; GRIN1/GRIN2B	3	Glutamate NMDA receptor; GRIN1/GRIN2B antagonist; Glutamate [NMDA] receptor negative allosteric modulator	Phase 3	https://conductscience.org/library/genes/2902	Drugs and targets
GRIN2A	Glutamate [NMDA] receptor	3	Glutamate [NMDA] receptor negative allosteric modulator; Glutamate [NMDA] receptor subunit epsilon 1 antagonist	Phase 3	https://conductscience.org/library/genes/2903	Drugs and targets
GRIN2B	Glutamate NMDA receptor; GRIN1/GRIN2B	3	Glutamate NMDA receptor; GRIN1/GRIN2B antagonist; Glutamate [NMDA] receptor negative allosteric modulator	Phase 3	https://conductscience.org/library/genes/2904	Drugs and targets
SCN9A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker; Sodium channel protein type IX alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6335	Drugs and targets
CACNA1A	Voltage-gated calcium channel	2	Voltage-gated calcium channel modulator	Phase 3	https://conductscience.org/library/genes/773	Drugs and targets
CACNA1B	Voltage-gated calcium channel	2	Voltage-gated calcium channel modulator	Phase 3	https://conductscience.org/library/genes/774	Drugs and targets

1 to 10 of 152

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Trials91

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 6 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01150045	Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery	Phase 3	2,527	2021-08-06	Colorectal Cancer	CELECOXIB, FLUOROURACIL, LEUCOVORIN CALCIUM, OXALIPLATIN	Its record names the disease	ClinicalTrials.gov
NCT00471445	Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Cancer Patients	Phase 3	462	2015-06-10	Neurotoxicity, Pain, Peripheral Neuropathy, Unspecified Adult Solid Tumor, Protocol Specific	AMITRIPTYLINE, KETAMINE	Its record names the disease	ClinicalTrials.gov
NCT04001829	Docetaxel or Paclitaxel in Reducing Chemotherapy-Induced Peripheral Neuropathy in African American Patients With Stage I-III Breast Cancer	Phase 2	249	2024-06-12	Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8, Invasive Breast Carcinoma, Prognostic Stage I Breast Cancer AJCC v8, Prognostic Stage IA Breast Cancer AJCC v8, Prognostic Stage IB Breast Cancer AJCC v8, Prognostic Stage II Breast Cancer AJCC v8, Prognostic Stage IIA Breast Cancer AJCC v8, Prognostic Stage IIB Breast Cancer AJCC v8, Prognostic Stage III Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8, Prognostic Stage IIIB Breast Cancer AJCC v8, Prognostic Stage IIIC Breast Cancer AJCC v8	DOCETAXEL, PACLITAXEL	Its record names the disease	ClinicalTrials.gov
NCT00489411	Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer	Phase 3	231	2017-04-26	Neurotoxicity, Pain, Peripheral Neuropathy, Unspecified Adult Solid Tumor, Protocol Specific	DULOXETINE HYDROCHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT00516503	Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer	Phase 3	208	2017-08-24	Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Neurotoxicity, Pain, Unspecified Adult Solid Tumor, Protocol Specific	AMITRIPTYLINE HYDROCHLORIDE, BACLOFEN, KETAMINE	Its record names the disease	ClinicalTrials.gov
NCT00412750	Efficacy and Safety of Telbivudine in Treatment naïve Patients With Hepatitis B e Antigen (HBeAg)-Positive Chronic Hepatitis B (CHB)	Phase 3	159	2011-07-13	Hepatitis B	PEGINTERFERON ALFA-2A, TELBIVUDINE	Its record names the disease	ClinicalTrials.gov
NCT00068445	Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer	Phase 3	131	2018-05-04	Neurotoxicity, Pain, Unspecified Adult Solid Tumor, Protocol Specific	LAMOTRIGINE	Its record names the disease	ClinicalTrials.gov
NCT00294671	The Effect of Diflunisal on Familial Amyloidosis	Phase 2/3	130	2017-03-17	Familial Amyloid Polyneuropathy, Familial Amyloidosis	DIFLUNISAL	Its record names the disease	ClinicalTrials.gov
NCT01906008	Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients	Phase 2	122	2020-03-17	Colorectal Cancer	MINOCYCLINE	Its record names the disease	ClinicalTrials.gov
NCT00365768	Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors	Phase 2	56	2016-09-09	Kidney Cancer, Leukemia, Lymphoma, Neurotoxicity, Peripheral Neuropathy, Sarcoma	GLUTAMINE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 91

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Comparisons in its trials25

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Amitriptyline and Ketamine Hydrochloride Topical Analgesic cr vs Placebo Cream: serious adverse events	4 of 227	4 of 231	458	NCT00471445	Trial comparisons
Arm A (Paclitaxel) vs Arm B (Docetaxel): deaths from any cause	7 of 126	6 of 123	249	NCT04001829	Trial comparisons
Arm A (Paclitaxel) vs Arm B (Docetaxel): serious adverse events	46 of 121	61 of 118	239	NCT04001829	Trial comparisons
Arm I/Group A (Duloxetine Then Placebo) vs Arm II/Group B (Placebo Then Duloxetine): serious adverse events	1 of 108	3 of 107	215	NCT00489411	Trial comparisons
Baclofen-amitriptyline Hydrochloride-ketamine vs Placebo: serious adverse events	1 of 101	1 of 102	203	NCT00516503	Trial comparisons
Diflunisal vs Placebo: serious adverse events	3 of 64	4 of 66	130	NCT00294671	Trial comparisons
Arm I - Lamotrigine vs Arm II - Placebo: deaths from any cause	0 of 61	0 of 63	124	NCT00068445	Trial comparisons
Arm I - Lamotrigine vs Arm II - Placebo: serious adverse events	0 of 61	0 of 63	124	NCT00068445	Trial comparisons
Minocycline vs Placebo: deaths from any cause	0 of 32	0 of 34	66	NCT01906008	Trial comparisons
Minocycline vs Placebo: serious adverse events	0 of 32	0 of 34	66	NCT01906008	Trial comparisons

1 to 10 of 25

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Papers from its trials72

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
37951905	RESULT	1	PubMed
34174668	RESULT	1	PubMed
33738491	RESULT	1	PubMed
32663120	RESULT	1	PubMed
32379556	RESULT	1	PubMed
31798378	RESULT	1	PubMed
31779159	RESULT	1	PubMed
31196236	RESULT	1	PubMed
30250104	RESULT	1	PubMed
28119855	RESULT	1	PubMed

1 to 10 of 72

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_0004149

GET https://conductscience.org/api/diseases/v1/EFO_0004149/drugs?page=2

API reference For AI assistants