Disease · EFO_0009636

cesarean section

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. cesarean section. Diseases, record EFO_0009636. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0009636

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: cesarean section; Open Targets
Open Targets ID: EFO_0009636; Open Targets
Other names: caesarean section; Open Targets
NCI Thesaurus: C46088; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 8 of its 25 drugs, from ClinicalTrials.gov; Open Targets

Drugs25

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
BUPIVACAINE	CHEMBL1098	Small molecule	Phase 3	ClinicalTrials.gov	15	15	15	Drugs and targets
MISOPROSTOL	CHEMBL606	Small molecule	Phase 3	ClinicalTrials.gov	6	6	6	Drugs and targets
PRILOCAINE	CHEMBL1194	Small molecule	Phase 3	ClinicalTrials.gov	5	5	5	Drugs and targets
OXYTOCIN	CHEMBL395429	Protein	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
GRANISETRON	CHEMBL289469	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
TRANEXAMIC ACID	CHEMBL877	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
ONDANSETRON	CHEMBL46	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
OXYGEN	CHEMBL1234886	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
FENTANYL	CHEMBL596	Small molecule	Phase 2/3	ClinicalTrials.gov	5	5	5	Drugs and targets
DEXMEDETOMIDINE	CHEMBL778	Small molecule	Phase 2/3	ClinicalTrials.gov	3	3	3	Drugs and targets

1 to 10 of 25

See all 25 drugs

Targets43

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SCN4A	Sodium channel alpha subunit	6	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6329	Drugs and targets
OPRM1	Mu-type opioid receptor	5	Mu opioid receptor agonist; Opioid receptors; mu/kappa/delta agonist	Phase 2/3	https://conductscience.org/library/genes/4988	Drugs and targets
SCN10A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6336	Drugs and targets
SCN11A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/11280	Drugs and targets
SCN1A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6323	Drugs and targets
SCN2A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6326	Drugs and targets
SCN3A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6328	Drugs and targets
SCN5A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6331	Drugs and targets
SCN7A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6332	Drugs and targets
SCN8A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6334	Drugs and targets

1 to 10 of 43

See all 43 targets

Trials37

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02973048	Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia	Phase 3	40	2020-07-02	Pregnant Women, Pain, Hypotension	BUPIVACAINE, PRILOCAINE	Its record names the disease	ClinicalTrials.gov
NCT01765881	Comparison Between 25 µg Vaginal Misoprostol vs Slow Release Pessary PGE2	Phase 2	1,700		Delivery Uterine	MISOPROSTOL	Its record names the disease	ClinicalTrials.gov
NCT00973791	Fluid Management for Cesarean Section II	Not applicable	860		Cesarean Section	HETASTARCH	Its record names the disease	ClinicalTrials.gov
NCT01585740	Ringer's Lactate Versus Normal Saline in Caesarean Section	Not applicable	500		Normal Anion Gap Metabolic Acidosis	SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT03435458	Balloon to Induce Labor in Generous Women.	Phase 3	429		Maternal Obesity	MISOPROSTOL	Its record names the disease	ClinicalTrials.gov
NCT01530971	Effect of Maternal and Neonatal Oxygenation	Phase 3	325		Peer Review, Research	OXYGEN	Its record names the disease	ClinicalTrials.gov
NCT03148717	Preoperative vs. Postoperative Rectal Misoprostol in Cesarean Section	Phase 2/3	300		Neonatal Outcome	MISOPROSTOL	Its record names the disease	ClinicalTrials.gov
NCT04313218	Carbetocin Versus Misoprostol. A Retrospective Comparative Study		300		Cesarean Section Complications	CARBETOCIN, MISOPROSTOL	Its record names the disease	ClinicalTrials.gov
NCT02788305	Effect of Maternal Obesity on Labour Induction in Postdate Pregnancy		288		Obesity, Induced; Birth	MISOPROSTOL	Its record names the disease	ClinicalTrials.gov
NCT03743870	Spinal Anesthesia in Caesarean Section		250		Hypotension Drug-Induced, Cesarean Section Complications, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use, Bradycardia	BUPIVACAINE, LEVOBUPIVACAINE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 37

See all 37 trials

Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Hyperbaric Bupivacaine vs Hyperbaric Prilocaine: Number of Participants With Transient Neurologic Symptoms (TNS)	0 of 19	0 of 17	36	NCT02973048	Trial comparisons
Hyperbaric Bupivacaine vs Hyperbaric Prilocaine: Number of Participants With Urinary Retention	2 of 19	2 of 17	36	NCT02973048	Trial comparisons
Hyperbaric Bupivacaine vs Hyperbaric Prilocaine: deaths from any cause	0 of 19	0 of 17	36	NCT02973048	Trial comparisons
Hyperbaric Bupivacaine vs Hyperbaric Prilocaine: serious adverse events	0 of 19	0 of 17	36	NCT02973048	Trial comparisons

Papers from its trials13

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
31962259	RESULT	1	PubMed
30322584	RESULT	1	PubMed
36996264	DERIVED	1	PubMed
35287618	DERIVED	1	PubMed
34714938	DERIVED	1	PubMed
34101713	DERIVED	1	PubMed
33887241	DERIVED	1	PubMed
33428221	DERIVED	1	PubMed
32606903	DERIVED	1	PubMed
30932170	DERIVED	1	PubMed

1 to 10 of 13

See all 13 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_0009636

GET https://conductscience.org/api/diseases/v1/EFO_0009636/drugs?page=2

API reference For AI assistants