Disease · EFO_1001491

abortion

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. abortion. Diseases, record EFO_1001491. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_1001491

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: abortion; Open Targets
Open Targets ID: EFO_1001491; Open Targets
Other names: loss of pregnancy; Open Targets
MeSH: D000028; MeSH
Highest stage of its drugs: Approval, for 2 of its 18 drugs, from TTD; Open Targets

Drugs18

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
CARBOPROST TROMETHAMINE	CHEMBL1237105	Small molecule	Approval	TTD	1	0	0	Drugs and targets
DINOPROST TROMETHAMINE	CHEMBL1200896	Small molecule	Approval	TTD	1	0	0	Drugs and targets
HUMAN IMMUNOGLOBULIN G	CHEMBL1201599		Phase 3	ClinicalTrials.gov	2	2	0	Drugs and targets
LEVOTHYROXINE	CHEMBL1624	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
LIDOCAINE	CHEMBL79	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
PROGESTERONE	CHEMBL103	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
MISOPROSTOL	CHEMBL606	Small molecule	Phase 2	ClinicalTrials.gov	11	11	11	Drugs and targets
ISOSORBIDE MONONITRATE	CHEMBL1311	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
LETROZOLE	CHEMBL1444	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
PREDNISOLONE	CHEMBL131	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 18

See all 18 drugs

Targets26

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
PGR	Progesterone receptor	3	Progesterone receptor agonist; Progesterone receptor antagonist	Phase 3	https://conductscience.org/library/genes/5241	Drugs and targets
NR3C1	Glucocorticoid receptor	2	Glucocorticoid receptor agonist; Glucocorticoid receptor antagonist	Phase 2	https://conductscience.org/library/genes/2908	Drugs and targets
PTGFR	Prostaglandin F2-alpha receptor	2	Prostanoid FP receptor agonist	Approval	https://conductscience.org/library/genes/5737	Drugs and targets
CYP19A1	Aromatase	1	Cytochrome P450 19A1 inhibitor	Phase 2	https://conductscience.org/library/genes/1588	Drugs and targets
ESR1	Estrogen receptor	1	Estrogen receptor alpha agonist	Unknown	https://conductscience.org/library/genes/2099	Drugs and targets
FFAR2	Free fatty acid receptor 2	1	Free fatty acid receptor 2 antagonist	Phase 2	https://conductscience.org/library/genes/2867	Drugs and targets
GNRHR	Gonadotropin-releasing hormone receptor	1	Gonadotropin-releasing hormone receptor agonist	Unknown	https://conductscience.org/library/genes/2798	Drugs and targets
GUCY1A1	Soluble guanylate cyclase	1	Soluble guanylate cyclase activator	Phase 2	https://conductscience.org/library/genes/2982	Drugs and targets
GUCY1A2	Soluble guanylate cyclase	1	Soluble guanylate cyclase activator	Phase 2	https://conductscience.org/library/genes/2977	Drugs and targets
GUCY1B1	Soluble guanylate cyclase	1	Soluble guanylate cyclase activator	Phase 2	https://conductscience.org/library/genes/2983	Drugs and targets

1 to 10 of 26

See all 26 targets

Trials20

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 2 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02447029	Self-Administered Lidocaine Gel for Pain Management With First Trimester Surgical Abortion: A Randomized Controlled Trial	Phase 3	142	2017-07-24	Pregnancy, Unwanted	LIDOCAINE	Its record names the disease	ClinicalTrials.gov
NCT01862991	Pre-Operative Effects of Mifepristone on Dilation and Evacuation Services	Not applicable	80	2017-06-01	Legally Induced Abortion Without Mention of Complication	MIFEPRISTONE	Its record names the disease	ClinicalTrials.gov
NCT02633878	Chinese Herbal Medicine (New "Shoutai Wan") and/or Oral Progesterone Intervention Trial for Threatened Miscarriage	Phase 3	1,656		Threatened Miscarriage	PROGESTERONE	Open Targets' reading of its record	ClinicalTrials.gov
NCT00286208	Study of Sublingual Versus Oral Misoprostol Administration Following Mifepristone 200 mg for Abortion up to 63 Days Gestation	Not applicable	1,443		Induced Abortion	MIFEPRISTONE, MISOPROSTOL	Its record names the disease	ClinicalTrials.gov
NCT03931460	Feasibility of Medical Abortion by Telemedicine in Mexico		1,114		Pregnancy	IBUPROFEN, MIFEPRISTONE, MISOPROSTOL	Its record names the disease	ClinicalTrials.gov
NCT01173003	Expansion Study of a Simplified Regimen of Medical Abortion Thru 63 Last Menstrual Period (LMP) in Tunisia	Not applicable	688		Induced Abortion	MIFEPRISTONE, MISOPROSTOL	Its record names the disease	ClinicalTrials.gov
NCT02219100	Acceptability and Feasibility of a Demedicalized Medical Abortion Regimen in the Caucasus	Not applicable	613		Abortion, First Trimester	MIFEPRISTONE	Its record names the disease	ClinicalTrials.gov
NCT04194658	Effectiveness of Pretreatment Letrozole Versus Misoprostol Alone in Missed Abortion	Phase 2	150		Medical; Abortion, Fetus	LETROZOLE, MISOPROSTOL	Its record names the disease	ClinicalTrials.gov
NCT06818903	Misoprostol in Missed Abortion		122		Abortion; Attempted	MISOPROSTOL	Its record names the disease	ClinicalTrials.gov
NCT00784186	Mifepristone and Misoprostol Versus Misoprostol Alone for Mid-trimester Termination of Pregnancy (14 - 21 Weeks LMP): A Randomized-controlled Double-blinded Trial	Not applicable	120		Abortion, Induced	MIFEPRISTONE, MISOPROSTOL	Its record names the disease	ClinicalTrials.gov

1 to 10 of 20

See all 20 trials

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Active Comparator vs Standard Lidocaine Paracervical Block: Overall Complication Rate as Measured by a Count of Participants in Each Group	0 of 69	0 of 68	137	NCT02447029	Trial comparisons
Active Comparator vs Standard Lidocaine Paracervical Block: serious adverse events	0 of 69	0 of 68	137	NCT02447029	Trial comparisons

Papers from its trials8

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
23820515	RESULT	1	PubMed
23169413	RESULT	1	PubMed
7507132	RESULT	1	PubMed
41263919	DERIVED	1	PubMed
36137638	DERIVED	1	PubMed
27400015	DERIVED	1	PubMed
21860289	DERIVED	1	PubMed
18055725	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_1001491

GET https://conductscience.org/api/diseases/v1/EFO_1001491/targets?page=2

API reference For AI assistants