Disease · EFO_1001905

oxidative stress

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. oxidative stress. Diseases, record EFO_1001905. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_1001905

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: oxidative stress; Open Targets
Open Targets ID: EFO_1001905; Open Targets
MeSH: D018384; MeSH
Highest stage of its drugs: Phase 3, for 4 of its 30 drugs, from ClinicalTrials.gov; Open Targets

Drugs30

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
ASCORBIC ACID	CHEMBL196	Small molecule	Phase 3	ClinicalTrials.gov	5	5	4	Drugs and targets
CURCUMIN	CHEMBL140	Small molecule	Phase 3	ClinicalTrials.gov	2	2	1	Drugs and targets
BAZEDOXIFENE	CHEMBL46740	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
ESTROGEN	CHEMBL592868	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
FENTANYL	CHEMBL596	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
OXYTOCIN	CHEMBL395429	Protein	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ACETYLCYSTEINE	CHEMBL600	Small molecule	Phase 1	ClinicalTrials.gov	2	2	1	Drugs and targets
CAFICRESTAT	CHEMBL4297455	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
RESAMIRIGENE BILPARVOVEC	CHEMBL4298181	Gene	Phase 1	ClinicalTrials.gov	1	1	0	Drugs and targets
PROPOFOL	CHEMBL526	Small molecule	Unknown	ClinicalTrials.gov	2	2	2	Drugs and targets

1 to 10 of 30

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Targets44

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
GABRA1	GABA-A receptor; anion channel	5	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2554	Drugs and targets
GABRA2	GABA-A receptor; anion channel	5	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2555	Drugs and targets
GABRA3	GABA-A receptor; anion channel	5	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2556	Drugs and targets
GABRA4	GABA-A receptor; anion channel	5	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2557	Drugs and targets
GABRA5	GABA-A receptor; anion channel	5	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2558	Drugs and targets
GABRA6	GABA-A receptor; anion channel	5	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2559	Drugs and targets
GABRB1	GABA-A receptor; anion channel	5	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2560	Drugs and targets
GABRB2	GABA-A receptor; anion channel	5	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2561	Drugs and targets
GABRB3	GABA-A receptor; anion channel	5	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2562	Drugs and targets
GABRD	GABA-A receptor; anion channel	5	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2563	Drugs and targets

1 to 10 of 44

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Trials19

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 3 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01301027	Effect of Adipokines in Hemodialysis Patients	Not applicable	95	2016-10-03	End Stage Renal Disease	PIOGLITAZONE	Its record names the disease	ClinicalTrials.gov
NCT02406586	Free Fatty Acids-Induced Hypertension in Obese Subjects (Aim #2)	Not applicable	36	2015-05-28	Hypertension, Diabetes	CARVEDILOL, SALSALATE	Its record names the disease	ClinicalTrials.gov
NCT01251315	The Effects of a Glutathione Precursor (FT061452),on Serum and Intracellular Glutathione Levels	Phase 1	24	2014-03-17	Oxidative Stress	ACETYLCYSTEINE	Its record names the disease	ClinicalTrials.gov
NCT07152912	Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy	Not applicable	80		Isoflurane, Sevoflurane, Oxidative Stress, Laparoscopic Cholecystectomy	ISOFLURANE, SEVOFLURANE	Its record names the disease	ClinicalTrials.gov
NCT00839085	Comparison of Ascorbic Acid and Grape Seed Extract in Oxidative Stress Induced by on Pump Heart Surgery	Not applicable	72		CABG-Induced Oxidative Stress	ASCORBIC ACID	Its record names the disease	ClinicalTrials.gov
NCT03632460	Dexmedetomidine and Dexamethasone as an Adjuvant to Ropivacaine in Thoracic Surgery	Not applicable	60		Pain, Postoperative, Oxidative Stress	DEXAMETHASONE, DEXMEDETOMIDINE	Its record names the disease	ClinicalTrials.gov
NCT07271472	Oxidative Stress Effects of TIVA, CIVA, and Balanced Anesthesia in VATS	Not applicable	60		VATS, Video Assisted Thoracoscopic Surgery	DESFLURANE, MIDAZOLAM, PROPOFOL, REMIFENTANIL, ROCURONIUM	Its record names the disease	ClinicalTrials.gov
NCT07148882	Pain Managment in Preterm Neonates	Phase 2/3	52		Preterm Neonates Pain Managment, PreTerm Neonate	FENTANYL	Its record names the disease	ClinicalTrials.gov
NCT05289349	Propofol or Sevoflurane Anesthesia in Egyptian Patients	Not applicable	44		Anesthesia	PROPOFOL, SEVOFLURANE	Its record names the disease	ClinicalTrials.gov
NCT00356252	Biological Functions of Carotenoids in Humans	Not applicable	40		Oxidative DNA Damage	BETA CAROTENE, LUTEIN, LYCOPENE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 19

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Comparisons in its trials1

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial
Pioglitazone vs Placebo: serious adverse events	11 of 48	10 of 47	95	NCT01301027

Source Trial comparisons

Papers from its trials25

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
29333256	RESULT	1	PubMed
29325842	RESULT	1	PubMed
28924366	RESULT	1	PubMed
28535549	RESULT	1	PubMed
27645688	RESULT	1	PubMed
26285072	RESULT	1	PubMed
26175690	RESULT	1	PubMed
26070314	RESULT	1	PubMed
25587641	RESULT	1	PubMed
25389409	RESULT	1	PubMed

1 to 10 of 25

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_1001905

GET https://conductscience.org/api/diseases/v1/EFO_1001905/drugs?page=2

API reference For AI assistants