Disease · EFO_1002005

lumbar disc herniation

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. lumbar disc herniation. Diseases, record EFO_1002005. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_1002005

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: lumbar disc herniation
Open Targets ID: EFO_1002005
Other names: lumbar disk herniation
Highest stage of its drugs: Phase 3, for 5 of its 18 drugs, from ClinicalTrials.gov

Source Open Targets

Drugs18

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
CONDOLIASE	CHEMBL2107876	Enzyme	Phase 3	ClinicalTrials.gov	5	5	5	Drugs and targets
DEXAMETHASONE	CHEMBL384467	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
LIDOCAINE	CHEMBL79	Small molecule	Phase 3	ClinicalTrials.gov	3	3	2	Drugs and targets
BUPIVACAINE	CHEMBL1098	Small molecule	Phase 3	ClinicalTrials.gov	1	1	0	Drugs and targets
PREGABALIN	CHEMBL1059	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
OXYGEN	CHEMBL1234886	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
OZONE	CHEMBL2447938	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
LACTIC ACID	CHEMBL1200559	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
BETAMETHASONE	CHEMBL632	Small molecule	Early phase 1	ClinicalTrials.gov	2	2	2	Drugs and targets
METHYLPREDNISOLONE ACETATE	CHEMBL1364144	Small molecule	Early phase 1	ClinicalTrials.gov	2	2	1	Drugs and targets

1 to 10 of 18

See all 18 drugs

Targets44

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	5	Glucocorticoid receptor agonist	Phase 3	https://conductscience.org/library/genes/2908	Drugs and targets
SCN4A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6329	Drugs and targets
ADRA2A	Adrenergic receptor alpha-2	2	Adrenergic receptor alpha-2 agonist	Unknown	https://conductscience.org/library/genes/150	Drugs and targets
ADRA2B	Adrenergic receptor alpha-2	2	Adrenergic receptor alpha-2 agonist	Unknown	https://conductscience.org/library/genes/151	Drugs and targets
ADRA2C	Adrenergic receptor alpha-2	2	Adrenergic receptor alpha-2 agonist	Unknown	https://conductscience.org/library/genes/152	Drugs and targets
SCN10A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6336	Drugs and targets
SCN11A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/11280	Drugs and targets
SCN1A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6323	Drugs and targets
SCN2A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6326	Drugs and targets
SCN3A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6328	Drugs and targets

1 to 10 of 44

See all 44 targets

Trials16

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02421601	A Study of SI-6603 in Patients With Lumbar Disc Herniation	Phase 3	1,011	2021-11-11	Intervertebral Disc Disease, Lumbar Disc Disease	CONDOLIASE	Its record names the disease	ClinicalTrials.gov
NCT03607838	SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)	Phase 3	352	2025-07-11	Lumbar Disc Herniation	CONDOLIASE	Its record names the disease	ClinicalTrials.gov
NCT03101033	Epidural Neuroplasty for the Treatment of Herniated Lumbar Disk	Not applicable	92	2018-09-04	Herniated Lumbar Disc	BETAMETHASONE	Open Targets' reading of its record	ClinicalTrials.gov
NCT01397552	Dexamethasone Versus Depo Medrol in Lumbar Epidurals	Not applicable	8	2018-12-04	Lumbar Spine Disc Herniation, Lumbar Radiculitis, Lumbar Back Pain	DEXAMETHASONE, METHYLPREDNISOLONE ACETATE	Its record names the disease	ClinicalTrials.gov
NCT01941563	A Study of SI-6603 in Patients With Lumbar Disc Herniation	Phase 3	385		Intervertebral Disc Disease, Lumbar Disc Disease	CONDOLIASE	Its record names the disease	ClinicalTrials.gov
NCT00370799	Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain	Early phase 1	240		Low Back Pain	BETAMETHASONE, BETAMETHASONE SODIUM PHOSPHATE, LIDOCAINE	Its record names the disease	ClinicalTrials.gov
NCT00634946	SI-6603 Versus Placebo in Patients With Lumbar Disc Herniation	Phase 2/3	195		Lumbar Vertebra Hernia	CONDOLIASE	Its record names the disease	ClinicalTrials.gov
NCT01811251	Co-analgesic Effects of Dexamethasone and Pregabalin After Lumbar Slipped Disc Surgery	Phase 3	162		Patients Undergoing a Lumbar Slipped Disc Surgery	DEXAMETHASONE, PREGABALIN	Its record names the disease	ClinicalTrials.gov
NCT00566007	The Effect of Ozone Therapy for Lumbar Herniated Disc	Phase 2	156		Lumbar Herniated Disc	OXYGEN, OZONE	Open Targets' reading of its record	ClinicalTrials.gov
NCT07411326	Does Intraoperative Application of Steroids Affect Early Outcomes in Patients Undergoing Endoscopic Lumbar Discectomy?	Not applicable	90		Lumbar Radiculopathy, Lumbar Herniated Disk	DEXAMETHASONE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 16

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Comparisons in its trials6

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
SI-6603 vs Sham: deaths from any cause	1 of 167	0 of 174	341	NCT03607838	Trial comparisons
SI-6603 vs Sham: serious adverse events	7 of 167	6 of 174	341	NCT03607838	Trial comparisons
Transforaminal Steroid Injection Group vs Epidural Neuroplasty Group: deaths from any cause	0 of 60	0 of 32	92	NCT03101033	Trial comparisons
Transforaminal Steroid Injection Group vs Epidural Neuroplasty Group: serious adverse events	0 of 60	0 of 32	92	NCT03101033	Trial comparisons
Dexamethasone vs Methylprednisolone Acetate: deaths from any cause	0 of 4	0 of 4	8	NCT01397552	Trial comparisons
Dexamethasone vs Methylprednisolone Acetate: serious adverse events	0 of 4	0 of 4	8	NCT01397552	Trial comparisons

Papers from its trials7

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
40648907	DERIVED	1	PubMed
40066868	DERIVED	1	PubMed
39168360	DERIVED	1	PubMed
29424676	DERIVED	1	PubMed
22828681	DERIVED	1	PubMed
21267039	DERIVED	1	PubMed
21102963	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_1002005

GET https://conductscience.org/api/diseases/v1/EFO_1002005/targets?page=2

API reference For AI assistants