Disease · HP_0000789

Infertility

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Infertility. Diseases, record HP_0000789. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0000789

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Infertility
Open Targets ID: HP_0000789
Highest stage of its drugs: Approval, for 6 of its 115 drugs, from EMA Human Drugs, PMDA and TTD

Source Open Targets

Drugs115

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
PROGESTERONE	CHEMBL103	Small molecule	Approval	PMDA	59	58	58	Drugs and targets
CHORIOGONADOTROPIN ALFA	CHEMBL1201464	Protein	Approval	PMDA	33	32	4	Drugs and targets
CORIFOLLITROPIN ALFA	CHEMBL2108185	Protein	Approval	TTD	22	21	20	Drugs and targets
FOLLITROPIN BETA	CHEMBL5315126	Protein	Approval	EMA Human Drugs	14	12	6	Drugs and targets
CYCLOFENIL	CHEMBL141305	Small molecule	Approval	TTD	1	0	0	Drugs and targets
IDURSULFASE	CHEMBL1201826	Enzyme	Approval	TTD	1	0	0	Drugs and targets
FOLLITROPIN	CHEMBL4297955		Phase 3	ClinicalTrials.gov	44	43	38	Drugs and targets
GONADOTROPIN, CHORIONIC	CHEMBL1201509	Protein	Phase 3	ClinicalTrials.gov	40	40	12	Drugs and targets
MENOTROPINS	CHEMBL2108427	Protein	Phase 3	ClinicalTrials.gov	40	40	9	Drugs and targets
LETROZOLE	CHEMBL1444	Small molecule	Phase 3	ClinicalTrials.gov	36	36	36	Drugs and targets

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Targets150

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
GNRHR	Gonadotropin-releasing hormone receptor	16	Gonadotropin-releasing hormone receptor agonist; Gonadotropin-releasing hormone receptor antagonist	Phase 3	https://conductscience.org/library/genes/2798	Drugs and targets
PGR	Progesterone receptor	10	Progesterone receptor agonist; Progesterone receptor modulator	Approval	https://conductscience.org/library/genes/5241	Drugs and targets
ESR1	Estrogen receptor	7	Estrogen receptor alpha agonist; Estrogen receptor alpha modulator; Estrogen receptor modulator	Approval	https://conductscience.org/library/genes/2099	Drugs and targets
FSHR	Follicle-stimulating hormone receptor	7	Follicle stimulating hormone receptor agonist	Approval	https://conductscience.org/library/genes/2492	Drugs and targets
CSF3R	Granulocyte colony-stimulating factor receptor	4	Granulocyte colony stimulating factor receptor agonist	Phase 1/2	https://conductscience.org/library/genes/1441	Drugs and targets
LHCGR	Lutropin-choriogonadotropic hormone receptor	4	Luteinizing hormone/Choriogonadotropin receptor agonist	Approval	https://conductscience.org/library/genes/3973	Drugs and targets
PDE5A	3',5'-cyclic phosphodiesterase	4	3',5'-cyclic phosphodiesterase inhibitor; Phosphodiesterase 5A inhibitor	Phase 2/3	https://conductscience.org/library/genes/8654	Drugs and targets
GLP1R	Glucagon-like peptide 1 receptor	3	Glucagon-like peptide 1 receptor agonist	Phase 3	https://conductscience.org/library/genes/2740	Drugs and targets
SERPINC1	Antithrombin-III	3	Antithrombin-III activator	Phase 1	https://conductscience.org/library/genes/462	Drugs and targets
CYP19A1	Aromatase	2	Cytochrome P450 19A1 inhibitor	Phase 3	https://conductscience.org/library/genes/1588	Drugs and targets

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Trials305

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 36 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT04854707	An Observational Study of Follitropin Alpha Biosimilar: the Real-world Data		5,484	2021-10-22	Reproductive Issues, Reproductive Disorder, Fertility Disorders, Fertility Issues, Gynecologic Disease, IVF	FOLLITROPIN ALFA	Its record names the disease	ClinicalTrials.gov
NCT00696800	A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787)	Phase 3	1,509	2014-08-21	In Vitro Fertilization	CORIFOLLITROPIN ALFA, FOLLITROPIN BETA	Its record names the disease	ClinicalTrials.gov
NCT02491437	A Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Crinone 8% Intravaginal Progesterone Gel 90 mg Daily for Luteal Support in In-Vitro Fertilization (LOTUS II)	Phase 3	1,034	2019-10-01	Female Infertility	DYDROGESTERONE, PROGESTERONE	Its record names the disease	ClinicalTrials.gov
NCT03296527	Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Pan-Asian Women	Phase 3	1,011	2021-06-01	Controlled Ovarian Simulation	FOLLITROPIN ALFA, FOLLITROPIN DELTA	Its record names the disease	ClinicalTrials.gov
NCT01044862	Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation	Phase 3	900	2015-02-02	Pregnancy, Unexplained Infertility	CLOMIPHENE CITRATE, FOLLITROPIN, LETROZOLE	Its record names the disease	ClinicalTrials.gov
NCT00828191	Subcutaneous Progesterone Versus Vaginal Progesterone Tablets for Luteal Phase Support in In Vitro Fertilization (IVF)	Phase 3	800	2012-12-26	In Vitro Fertilization	PROGESTERONE	Its record names the disease	ClinicalTrials.gov
NCT00719186	Pregnancy in Polycystic Ovary Syndrome II	Phase 3	750	2014-06-09	Pregnancy, Polycystic Ovary Syndrome	CLOMIPHENE CITRATE, LETROZOLE	Its record names the disease	ClinicalTrials.gov
NCT00827983	Subcutaneous Progesterone Versus Vaginal Progesterone Gel for Luteal Phase Support in Patients Undergoing In-Vitro Fertilization (IVF)	Phase 3	683	2012-12-26	In Vitro Fertilization	PROGESTERONE	Its record names the disease	ClinicalTrials.gov
NCT00696878	Corifollitropin Alfa in Participants Undergoing Repeated Controlled Ovarian Stimulation (COS) Cycles Using a Multiple Dose Gonadatropin Releasing Hormone (GnRH) Antagonist Protocol (Study 38825)(P05714)	Phase 3	682	2015-04-23	In Vitro Fertilization	CORIFOLLITROPIN ALFA, GONADORELIN ACETATE, GONADOTROPIN, CHORIONIC, MENOTROPINS	Its record names the disease	ClinicalTrials.gov
NCT01416987	A Korean Post-Marketing Surveillance Study On Pergoveris® (Follitropin Alfa + Lutropin Alfa)		600	2019-07-19	Infertility	FOLLITROPIN ALFA	Its record names the disease	ClinicalTrials.gov

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See all 305 trials

Comparisons in its trials69

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
150 µg Corifollitropin Alfa vs 200 IU recFSH: serious adverse events	35 of 755	30 of 751	1,506	NCT00696800	Trial comparisons
FE 000049 (Follitropin Delta) vs GONAL-F (Follitropin Alfa): deaths from any cause	0 of 499	0 of 510	1,009	NCT03296527	Trial comparisons
FE 000049 (Follitropin Delta) vs GONAL-F (Follitropin Alfa): serious adverse events	30 of 499	18 of 510	1,009	NCT03296527	Trial comparisons
Progesterone SC vs Progesterone Tablets: serious adverse events	0 of 400	0 of 400	800	NCT00828191	Trial comparisons
Arm A: Clomiphene Citrate vs Arm B: Letrozole: Live Birth	72 of 376	103 of 374	750	NCT00719186	Trial comparisons
Arm A: Clomiphene Citrate vs Arm B: Letrozole: Number of Pregnancy	103 of 376	154 of 374	750	NCT00719186	Trial comparisons
Arm A: Clomiphene Citrate vs Arm B: Letrozole: serious adverse events	13 of 376	21 of 374	750	NCT00719186	Trial comparisons
Progesterone SC vs Progesterone Vaginal Gel: serious adverse events	14 of 338	20 of 344	682	NCT00827983	Trial comparisons
Infants Corifollitropin Alfa 150 µg vs Infants recFSH 200 IU: Number of Infants Born in Current Follow Up Trial Experiencing AEs	164 of 344	161 of 315	659	NCT00703014	Trial comparisons
Infants Corifollitropin Alfa 150 µg vs Infants recFSH 200 IU: Number of Infants in Current Follow Up Trial Experiencing SAEs	106 of 344	94 of 315	659	NCT00703014	Trial comparisons

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Papers from its trials320

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
40979710	RESULT	1	PubMed
37835035	RESULT	1	PubMed
37599566	RESULT	1	PubMed
37194068	RESULT	1	PubMed
37156263	RESULT	1	PubMed
36619578	RESULT	1	PubMed
36483694	RESULT	1	PubMed
36195924	RESULT	1	PubMed
35595197	RESULT	1	PubMed
34583840	RESULT	1	PubMed

1 to 10 of 320

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0000789

GET https://conductscience.org/api/diseases/v1/HP_0000789/drugs?page=2

API reference For AI assistants