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Disease · HP_0001742

Nasal congestion

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. Nasal congestion. Diseases, record HP_0001742. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0001742

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
Nasal congestion
Open Targets ID
HP_0001742
Other names
Blockage of nose, Nasal blockage, Nasal obstruction, Obstruction of nose, Stuffy nose
Highest stage of its drugs
Approval, for 71 of its 82 drugs, from ATC, DailyMed and TTD

Source Open Targets

Drugs82

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
PHENYLEPHRINE HYDROCHLORIDECHEMBL1200339Small moleculeApprovalDailyMed11944Drugs and targets
FLUTICASONE PROPIONATECHEMBL1473Small moleculeApprovalATC and DailyMed633Drugs and targets
OXYMETAZOLINECHEMBL762Small moleculeApprovalATC and TTD633Drugs and targets
MOMETASONE FUROATECHEMBL1161Small moleculeApprovalATC and DailyMed533Drugs and targets
CHLORPHENIRAMINE MALEATECHEMBL1659Small moleculeApprovalDailyMed2522Drugs and targets
PHENYLEPHRINECHEMBL1215Small moleculeApprovalATC622Drugs and targets
PSEUDOEPHEDRINECHEMBL1590Small moleculeApprovalATC, DailyMed and TTD622Drugs and targets
ACETAMINOPHENCHEMBL112Small moleculeApprovalDailyMed6711Drugs and targets
PSEUDOEPHEDRINE HYDROCHLORIDECHEMBL1200724Small moleculeApprovalDailyMed4011Drugs and targets
BROMPHENIRAMINE MALEATECHEMBL1200961Small moleculeApprovalDailyMed1111Drugs and targets

1 to 10 of 82

See all 82 drugs

Targets28

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
HRH1Histamine H1 receptor16Histamine H1 receptor antagonistApprovalhttps://conductscience.org/library/genes/3269Drugs and targets
ADRA1AAdrenergic receptor13Adrenergic receptor agonist; Adrenergic receptor alpha agonist; Adrenergic receptor alpha-1 agonist; Alpha-1a adrenergic receptor agonistApprovalhttps://conductscience.org/library/genes/148Drugs and targets
NR3C1Glucocorticoid receptor13Glucocorticoid receptor agonistApprovalhttps://conductscience.org/library/genes/2908Drugs and targets
ADRA1BAdrenergic receptor12Adrenergic receptor agonist; Adrenergic receptor alpha agonist; Adrenergic receptor alpha-1 agonistApprovalhttps://conductscience.org/library/genes/147Drugs and targets
ADRA1DAdrenergic receptor12Adrenergic receptor agonist; Adrenergic receptor alpha agonist; Adrenergic receptor alpha-1 agonistApprovalhttps://conductscience.org/library/genes/146Drugs and targets
ADRA2AAdrenergic receptor9Adrenergic receptor agonist; Adrenergic receptor alpha agonistApprovalhttps://conductscience.org/library/genes/150Drugs and targets
ADRA2BAdrenergic receptor9Adrenergic receptor agonist; Adrenergic receptor alpha agonistApprovalhttps://conductscience.org/library/genes/151Drugs and targets
ADRA2CAdrenergic receptor9Adrenergic receptor agonist; Adrenergic receptor alpha agonistApprovalhttps://conductscience.org/library/genes/152Drugs and targets
ADRB1Adrenergic receptor3Adrenergic receptor agonistApprovalhttps://conductscience.org/library/genes/153Drugs and targets
ADRB2Adrenergic receptor3Adrenergic receptor agonistApprovalhttps://conductscience.org/library/genes/154Drugs and targets

1 to 10 of 28

See all 28 targets

Trials23

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT01386125A Study of the Effectiveness and Safety of Mometasone Furoate Nasal Spray (MFNS, SCH 032088) for the Treatment of Nasal Polyps (P05604)Phase 37482013-12-19Nasal PolypsMOMETASONE FUROATEIts record names the diseaseClinicalTrials.gov
NCT01413958Effects of Phenylephrine Extended-Release Tablets on Allergy-Related Nasal Congestion (P08498 AM1)Phase 35752013-01-29Seasonal Allergic RhinitisLORATADINE, PHENYLEPHRINE HYDROCHLORIDEIts record names the diseaseClinicalTrials.gov
NCT01448057Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and FluPhase 33412017-01-13Upper Respiratory Tract Infection, Nasal Congestion, Rhinorrhea, SneezingACETAMINOPHEN, DIMETHINDENE MALEATE, PHENYLEPHRINE HYDROCHLORIDEIts record names the diseaseClinicalTrials.gov
NCT00976209Consumer Preference Study of Two Formulations of Phenylephrine Hydrochloride (Study CL2008-15)(P07530)(COMPLETED)Phase 33312011-03-25Vasomotor Rhinitis, Seasonal Allergic RhinitisPHENYLEPHRINE HYDROCHLORIDEIts record names the diseaseClinicalTrials.gov
NCT01622569
Study Evaluating the Efficacy and Safety of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi Directional Device in Subjects With Bilateral Nasal Polyposis Followed by an 8-Week Open-Label Extension Phase to Assess Safety
Phase 33232018-12-05Bilateral Nasal PolyposisFLUTICASONE PROPIONATEIts record names the diseaseClinicalTrials.gov
NCT01624662Efficacy and Safety Study of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate Using a Novel Bi-directional DevicePhase 33232018-12-05Bilateral Nasal PolyposisFLUTICASONE PROPIONATEIts record names the diseaseClinicalTrials.gov
NCT02291549S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal PolypsPhase 33002018-07-09Chronic Sinusitis, Nasal PolyposisMOMETASONE FUROATEIts record names the diseaseClinicalTrials.gov
NCT03339726Randomized, Double-blind, Placebo-Controlled, Efficacy Study of a New Formulation of Phenylephrine HCL in the Common ColdPhase 21932019-06-04Common ColdPHENYLEPHRINE HYDROCHLORIDEIts record names the diseaseClinicalTrials.gov
NCT01098071Nasonex (Mometasone Furoate Nasal Spray) in Adenoids Hypertrophy in Children (P04367)Phase 4342011-11-29AdenoidsMOMETASONE FUROATEIts record names the diseaseClinicalTrials.gov
NCT00319995Effects of Loratadine/Montelukast vs Pseudoephedrine and Placebo in Patients With Seasonal Allergic Rhinitis (Study P04095) (COMPLETED)Phase 31,095Rhinitis, Allergic, SeasonalLORATADINE, MONTELUKASTIts record names the diseaseClinicalTrials.gov

1 to 10 of 23

See all 23 trials

Comparisons in its trials6

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
MFNS vs Placebo: serious adverse events2 of 3753 of 373748NCT01386125Trial comparisons
Phenylephrine HCl ER, 30 mg vs Phenylephrine HCl IR, 10 mg: serious adverse events0 of 3270 of 324651NCT00976209Trial comparisons
Phenylephrine vs Placebo: serious adverse events0 of 2880 of 287575NCT01413958Trial comparisons
Arm A vs Arm B: serious adverse events0 of 1700 of 171341NCT01448057Trial comparisons
Treatment vs Control: deaths from any cause0 of 2010 of 99300NCT02291549Trial comparisons
Treatment vs Control: serious adverse events1 of 2010 of 99300NCT02291549Trial comparisons

Papers from its trials10

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
26575524RESULT1PubMed
23010795RESULT1PubMed
42954986DERIVED1PubMed
36480111DERIVED1PubMed
35437059DERIVED2PubMed
34753535DERIVED2PubMed
29928924DERIVED1PubMed
26560899DERIVED1PubMed
26133030DERIVED1PubMed
19549427DERIVED1PubMed

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0001742

GET https://conductscience.org/api/diseases/v1/HP_0001742/drugs?page=2

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