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Disease · HP_0004308

Ventricular arrhythmia

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. Ventricular arrhythmia. Diseases, record HP_0004308. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0004308

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
Ventricular arrhythmia
Open Targets ID
HP_0004308
Other names
Ventricular arrhythmias
Highest stage of its drugs
Approval, for 16 of its 27 drugs, from DailyMed and TTD

Source Open Targets

Drugs27

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
LIDOCAINECHEMBL79Small moleculeApprovalDailyMed311Drugs and targets
PROCAINAMIDECHEMBL640Small moleculeApprovalTTD211Drugs and targets
ACEBUTOLOL HYDROCHLORIDECHEMBL1200813Small moleculeApprovalDailyMed600Drugs and targets
SOTALOL HYDROCHLORIDECHEMBL1700Small moleculeApprovalDailyMed600Drugs and targets
AMIODARONE HYDROCHLORIDECHEMBL1083993Small moleculeApprovalDailyMed200Drugs and targets
BRETYLIUM TOSYLATECHEMBL1095292Small moleculeApprovalDailyMed100Drugs and targets
DISOPYRAMIDECHEMBL517Small moleculeApprovalTTD100Drugs and targets
DISOPYRAMIDE PHOSPHATECHEMBL1201020Small moleculeApprovalDailyMed100Drugs and targets
DOFETILIDECHEMBL473Small moleculeApprovalDailyMed100Drugs and targets
FLECAINIDE ACETATECHEMBL1200822Small moleculeApprovalDailyMed100Drugs and targets

1 to 10 of 27

See all 27 drugs

Targets38

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
SCN5ASodium channel alpha subunit12Sodium channel alpha subunit blocker; Sodium channel protein type V alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6331Drugs and targets
SCN10ASodium channel alpha subunit10Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6336Drugs and targets
SCN11ASodium channel alpha subunit10Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/11280Drugs and targets
SCN1ASodium channel alpha subunit10Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6323Drugs and targets
SCN2ASodium channel alpha subunit10Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6326Drugs and targets
SCN3ASodium channel alpha subunit10Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6328Drugs and targets
SCN4ASodium channel alpha subunit10Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6329Drugs and targets
SCN7ASodium channel alpha subunit10Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6332Drugs and targets
SCN8ASodium channel alpha subunit10Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6334Drugs and targets
SCN9ASodium channel alpha subunit10Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6335Drugs and targets

1 to 10 of 38

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Trials8

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 2 more are not shown, since the checks do not confirm them.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT02104583Evaluating Ventricular Arrhythmia in Subjects With Implantable Cardioverter Defibrillator or Cardiac Resynchronization Therapy-DefibrillatorPhase 23132019-04-09Ventricular ArrhythmiaELECLAZINEIts record names the diseaseClinicalTrials.gov
NCT04600921Ertugliflozin to Reduce Arrhythmic Burden in ICD/CRT patientS (ERASe-Trial) - a Phase III StudyPhase 3552025-06-03Heart Failure With Reduced Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Implantable Cardioverter-Defibrillators, Cardiac Resynchronization TherapyERTUGLIFLOZINIts record names the diseaseClinicalTrials.gov
NCT03018834Anakinra Versus Placebo for the Treatment of Acute MyocarditISPhase 2/3120Acute MyocarditisANAKINRAIts record names the diseaseClinicalTrials.gov
NCT06158698CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With ColchicinePhase 380Cardiomyopathies, Myocarditis, Inflammatory Cardiomyopathy, Heart Failure, Ventricular ArrythmiaCOLCHICINEIts record names the diseaseClinicalTrials.gov
NCT07205757Adding Lidocaine to Custodiol MixturePhase 470CAD, Arrhythmia VentricularLIDOCAINEIts record names the diseaseClinicalTrials.gov
NCT05631730Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve ProlapsePhase 350Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac ArrestFLECAINIDE, METOPROLOLIts record names the diseaseClinicalTrials.gov
NCT01430806Dronaderone to Prevent Recurrent Implantable Cardioverter Defibrillator (ICD) ShocksNot applicable20ICD, ICD SHOCKS, DRONEDARONEDRONEDARONEIts record names the diseaseClinicalTrials.gov
NCT02575534Acute Mechanical Response to Anti-arrhythmic Drug TherapyNot applicable0ArrhythmiasPROCAINAMIDEIts record names the diseaseClinicalTrials.gov

Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Ertugliflozin vs Placebo: deaths from any cause3 of 253 of 3055NCT04600921Trial comparisons
Ertugliflozin vs Placebo: serious adverse events10 of 2521 of 3055NCT04600921Trial comparisons
Ertugliflozin vs Placebo: Atleast One Hospitalization Due to Heart Failure1 of 224 of 2446NCT04600921Trial comparisons
Ertugliflozin vs Placebo: Cardiovascular Mortality0 of 222 of 2446NCT04600921Trial comparisons

Papers from its trials12

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
22082198RESULT1PubMed
19917887RESULT1PubMed
16403928RESULT1PubMed
9078198RESULT1PubMed
9078197RESULT1PubMed
1900101RESULT1PubMed
1377359RESULT1PubMed
41730291DERIVED1PubMed
39705605DERIVED1PubMed
39217453DERIVED1PubMed

1 to 10 of 12

See all 12 papers from its trials

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0004308

GET https://conductscience.org/api/diseases/v1/HP_0004308/drugs?page=2

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