Disease · HP_0006682

Premature ventricular contraction

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Premature ventricular contraction. Diseases, record HP_0006682. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0006682

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Premature ventricular contraction
Open Targets ID: HP_0006682
Other names: Extra heart beat, Premature ventricular beat, Premature ventricular contractions, Ventricular ectopics, Ventricular extrasystoles, Ventricular premature beat
Highest stage of its drugs: Phase 3, for 1 of its 7 drugs, from ClinicalTrials.gov

Source Open Targets

Drugs7

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
AMIODARONE	CHEMBL633	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
FLECAINIDE	CHEMBL652	Small molecule	Phase 2	ClinicalTrials.gov	3	3	3	Drugs and targets
RANOLAZINE	CHEMBL1404	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
VARENICLINE	CHEMBL1076903	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
VARENICLINE TARTRATE	CHEMBL6067972	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
SOTALOL	CHEMBL471	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
VERAPAMIL	CHEMBL6966	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets11

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
CHRNA4	Neuronal acetylcholine receptor; alpha4/beta2	2	Neuronal acetylcholine receptor; alpha4/beta2 agonist; Neuronal acetylcholine receptor; alpha4/beta2 partial agonist	Phase 2	https://conductscience.org/library/genes/1137	Drugs and targets
CHRNB2	Neuronal acetylcholine receptor; alpha4/beta2	2	Neuronal acetylcholine receptor; alpha4/beta2 agonist; Neuronal acetylcholine receptor; alpha4/beta2 partial agonist	Phase 2	https://conductscience.org/library/genes/1141	Drugs and targets
KCNH2	Voltage-gated inwardly rectifying potassium channel KCNH2	2	HERG blocker	Phase 3	https://conductscience.org/library/genes/3757	Drugs and targets
SCN5A	Sodium channel protein type 5 subunit alpha	2	Sodium channel protein type V alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6331	Drugs and targets
ADRB1	Beta-1 adrenergic receptor	1	Beta-1 adrenergic receptor antagonist	Unknown	https://conductscience.org/library/genes/153	Drugs and targets
ADRB2	Beta-2 adrenergic receptor	1	Beta-2 adrenergic receptor antagonist	Unknown	https://conductscience.org/library/genes/154	Drugs and targets
CACNA1C	Voltage-gated L-type calcium channel	1	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/775	Drugs and targets
CACNA1D	Voltage-gated L-type calcium channel	1	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/776	Drugs and targets
CACNA1F	Voltage-gated L-type calcium channel	1	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/778	Drugs and targets
CACNA1S	Voltage-gated L-type calcium channel	1	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/779	Drugs and targets

1 to 10 of 11

See all 11 targets

Trials6

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01833455	Premature Ventricular Contractions (PVCs) and Blood Pressure Control	Phase 2	8	2019-02-22	Ventricular Premature Complexes, Blood Pressure	FLECAINIDE	Its record names the disease	ClinicalTrials.gov
NCT02360397	Ranolazine Mediated PVC Reduction in Ischemic Heart Disease	Phase 2	6	2020-01-29	Ventricular Premature Complexes, Myocardial Ischemia	RANOLAZINE	Its record names the disease	ClinicalTrials.gov
NCT06949748	Flecainide in Idiopathic Premature Ventricular Contractions and Related Cardiomyopathy		300		Premature Ventricular Beats, Premature Ventricular Complexes, Premature Ventricular Contraction (PVC), Arrhythmia Ventricular, Ventricular Dysfunction, Left, Ventricular Dysfunction, Cardiomyopathies, Secondary, Cardiomyopathies	FLECAINIDE	Its record names the disease	ClinicalTrials.gov
NCT06780215	Efficacy of Varenicline Tartrate in Treating Frequent Premature Ventricular Contractions	Phase 2	116		Premature Ventricular Contraction (PVC)	VARENICLINE, VARENICLINE TARTRATE	Its record names the disease	ClinicalTrials.gov
NCT02924285	Catheter Ablation Versus Amiodarone for Therapy of Premature Ventricular Contractions in Patients With Structural Heart Disease	Phase 3	80		Heart Diseases, Cardiomyopathies, Ventricular Premature Complexes	AMIODARONE	Its record names the disease	ClinicalTrials.gov
NCT03845010	Elimination of VPB With Ablation Versus Anti-arrhythmic Drug Treatment	Not applicable	22		Ventricular Premature Beats	FLECAINIDE, SOTALOL, VERAPAMIL	Open Targets' reading of its record	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
41778949	DERIVED	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0006682

GET https://conductscience.org/api/diseases/v1/HP_0006682/drugs

API reference For AI assistants