Disease · HP_0025095

Sneeze

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Sneeze. Diseases, record HP_0025095. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0025095

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Sneeze; Open Targets
Open Targets ID: HP_0025095; Open Targets
Other names: sneezing; Open Targets
MeSH: D012912; MeSH
NCI Thesaurus: C50746; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 6 of its 6 drugs, from ClinicalTrials.gov; Open Targets

Drugs6

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
CHLORPHENIRAMINE MALEATE	CHEMBL1659	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
ACETAMINOPHEN	CHEMBL112	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
ATROPINE SULFATE	CHEMBL2146146	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
DIMETHINDENE MALEATE	CHEMBL1870768	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
PHENYLEPHRINE HYDROCHLORIDE	CHEMBL1200339	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
PSEUDOEPHEDRINE HYDROCHLORIDE	CHEMBL1200724	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets12

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADRA1A	Adrenergic receptor alpha-1	1	Adrenergic receptor alpha-1 agonist	Phase 3	https://conductscience.org/library/genes/148	Drugs and targets
ADRA1B	Adrenergic receptor alpha-1	1	Adrenergic receptor alpha-1 agonist	Phase 3	https://conductscience.org/library/genes/147	Drugs and targets
ADRA1D	Adrenergic receptor alpha-1	1	Adrenergic receptor alpha-1 agonist	Phase 3	https://conductscience.org/library/genes/146	Drugs and targets
CHRM1	Muscarinic acetylcholine receptor M1	1	Muscarinic acetylcholine receptor M1 antagonist	Phase 3	https://conductscience.org/library/genes/1128	Drugs and targets
CHRM2	Muscarinic acetylcholine receptor M2	1	Muscarinic acetylcholine receptor M2 antagonist	Phase 3	https://conductscience.org/library/genes/1129	Drugs and targets
CHRM3	Muscarinic acetylcholine receptor M3	1	Muscarinic acetylcholine receptor M3 antagonist	Phase 3	https://conductscience.org/library/genes/1131	Drugs and targets
FAAH	Fatty-acid amide hydrolase 1	1	Anandamide amidohydrolase inhibitor	Phase 3	https://conductscience.org/library/genes/2166	Drugs and targets
HRH1	Histamine H1 receptor	1	Histamine H1 receptor antagonist	Phase 3	https://conductscience.org/library/genes/3269	Drugs and targets
PTGS1	Cyclooxygenase	1	Cyclooxygenase inhibitor	Phase 3	https://conductscience.org/library/genes/5742	Drugs and targets
PTGS2	Cyclooxygenase	1	Cyclooxygenase inhibitor	Phase 3	https://conductscience.org/library/genes/5743	Drugs and targets

1 to 10 of 12

See all 12 targets

Trials3

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01448057	Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu	Phase 3	341	2017-01-13	Upper Respiratory Tract Infection, Nasal Congestion, Rhinorrhea, Sneezing	ACETAMINOPHEN, DIMETHINDENE MALEATE, PHENYLEPHRINE HYDROCHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT01293201	Trial of STAHIST in Seasonal Allergic Rhinitis	Phase 3	290		Seasonal Allergic Rhinitis	ATROPINE SULFATE, CHLORPHENIRAMINE MALEATE, PSEUDOEPHEDRINE HYDROCHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT04790487	Chlorpheniramine Maleate Nasal Spray for Chronic Rhinitis	Phase 2/3	0		Allergic Rhinitis, Nasal Congestion	CHLORPHENIRAMINE MALEATE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials1

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial
Arm A vs Arm B: serious adverse events	0 of 170	0 of 171	341	NCT01448057

Source Trial comparisons

Papers from its trials0

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

None in this release.

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0025095

GET https://conductscience.org/api/diseases/v1/HP_0025095/drugs

API reference For AI assistants