Disease · MONDO_0003803

aortic valve disorder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. aortic valve disorder. Diseases, record MONDO_0003803. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0003803

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: aortic valve disorder; Open Targets
Open Targets ID: MONDO_0003803; Open Targets
Other names: aortic valve disease, aortic valve disease or disorder, disease of aortic valve, disease or disorder of aortic valve, disorder of aortic valve; Open Targets
Disease Ontology: DOID:62; Disease Ontology
NCI Thesaurus: C78650; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 3 of its 7 drugs, from ClinicalTrials.gov; Open Targets

Drugs7

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
ISOFLURANE	CHEMBL1256	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
PROPOFOL	CHEMBL526	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
SEVOFLURANE	CHEMBL1200694	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
EVOGLIPTIN	CHEMBL1779710	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
CARBON MONOXIDE	CHEMBL1231840	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
CARBON DIOXIDE	CHEMBL1231871	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
HYDROXYETHYL STARCH 130/0.4	CHEMBL2108701		Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets24

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
GABRA1	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator	Phase 3	https://conductscience.org/library/genes/2554	Drugs and targets
GABRA2	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator	Phase 3	https://conductscience.org/library/genes/2555	Drugs and targets
GABRA3	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator	Phase 3	https://conductscience.org/library/genes/2556	Drugs and targets
GABRA4	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator	Phase 3	https://conductscience.org/library/genes/2557	Drugs and targets
GABRA5	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator	Phase 3	https://conductscience.org/library/genes/2558	Drugs and targets
GABRA6	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator	Phase 3	https://conductscience.org/library/genes/2559	Drugs and targets
GABRB1	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator	Phase 3	https://conductscience.org/library/genes/2560	Drugs and targets
GABRB2	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator	Phase 3	https://conductscience.org/library/genes/2561	Drugs and targets
GABRB3	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator	Phase 3	https://conductscience.org/library/genes/2562	Drugs and targets
GABRD	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator	Phase 3	https://conductscience.org/library/genes/2563	Drugs and targets

1 to 10 of 24

See all 24 targets

Trials5

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00934596	CO2 Versus Lund De-airing Technique in Heart Surgery	Not applicable	20	2013-12-04	Aortic Valve Disorder	CARBON DIOXIDE	Its record names the disease	ClinicalTrials.gov
NCT01727167	CO as a Stimulant for Mitochondrial Biogenesis in Human Cardiac Muscle	Phase 1/2	1	2016-05-19	Cardiac Disease, Mitochondrial Biogenesis, Carbon Monoxide	CARBON MONOXIDE	Its record names the disease	ClinicalTrials.gov
NCT05143177	A Study to Evaluate the Efficacy and Safety of DA-1229 (Evogliptin) in Patient's Calcific Aortic Valve Disease With Mild to Moderate Aortic Stenosis (EVOID-AS)	Phase 2/3	486		Calcific Aortic Valve Disease	EVOGLIPTIN	Open Targets' reading of its record	ClinicalTrials.gov
NCT07329660	Crystalloid vs Colloid for Hemodynamics During Anesthesia Induction in TAVR Patients	Not applicable	116		Transcatheter Aortic Valve Replacement, Hemodynamic Stability, Anesthesia Induction	HYDROXYETHYL STARCH 130/0.4	Its record names the disease	ClinicalTrials.gov
NCT05696509	Influence of Anesthetics on Clinical Outcome in Mitral and Aortic Valve Replacement in Adults	Phase 3	75		Mitral Valve Insufficiency, Aortic Valve Insufficiency	ISOFLURANE, PROPOFOL, SEVOFLURANE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Lund De-airing Technique vs Carbon-dioxide Insufflation Technique: Number of Participants With <=Grade I Gas Emboli as Assessed by Trans-esophageal Echocardiography TEE).	9 of 10	7 of 10	20	NCT00934596	Trial comparisons
Lund De-airing Technique vs Carbon-dioxide Insufflation Technique: Number of Participants With <=Grade I Gas Emboli as Assessed by Trans-esophageal Echocardiography TEE).	9 of 10	7 of 10	20	NCT00934596	Trial comparisons
Lund De-airing Technique vs Carbon-dioxide Insufflation Technique: Number of Participants With <=Grade I Gas Emboli as Assessed by Trans-esophageal Echocardiography TEE).	10 of 10	4 of 10	20	NCT00934596	Trial comparisons
Lund De-airing vs Carbon-dioxide Insufflation: serious adverse events	0 of 10	0 of 10	20	NCT00934596	Trial comparisons

Papers from its trials4

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
42969906	DERIVED	1	PubMed
42902397	DERIVED	1	PubMed
23246060	DERIVED	1	PubMed
20817209	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0003803

GET https://conductscience.org/api/diseases/v1/MONDO_0003803/targets?page=2

API reference For AI assistants