Disease · MONDO_0004567

ileus

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. ileus. Diseases, record MONDO_0004567. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0004567

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: ileus; Open Targets
Open Targets ID: MONDO_0004567; Open Targets
Disease Ontology: DOID:8440; Disease Ontology
MeSH: D045823; MeSH
NCI Thesaurus: C37979; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 4 of its 10 drugs, from ClinicalTrials.gov; Open Targets

Drugs10

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
PRUCALOPRIDE	CHEMBL117287	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
BUPIVACAINE	CHEMBL1098	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
HYDROMORPHONE	CHEMBL398707	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
LIDOCAINE	CHEMBL79	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
PYRIDOSTIGMINE BROMIDE	CHEMBL812	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
ASIMADOLINE	CHEMBL1190199	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
CAFFEINE CITRATE	CHEMBL1200569	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
DEXAMETHASONE	CHEMBL384467	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ULIMORELIN HYDROCHLORIDE	CHEMBL1923502	Small molecule	Phase 2	TTD	1	0	0	Drugs and targets
OXYGEN	CHEMBL1234886	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets20

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SCN4A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6329	Drugs and targets
ACHE	Acetylcholinesterase	1	Acetylcholinesterase inhibitor	Phase 2/3	https://conductscience.org/library/genes/43	Drugs and targets
ADORA1	Adenosine receptor	1	Adenosine receptor antagonist	Phase 2	https://conductscience.org/library/genes/134	Drugs and targets
ADORA2A	Adenosine receptor	1	Adenosine receptor antagonist	Phase 2	https://conductscience.org/library/genes/135	Drugs and targets
ADORA2B	Adenosine receptor	1	Adenosine receptor antagonist	Phase 2	https://conductscience.org/library/genes/136	Drugs and targets
ADORA3	Adenosine receptor	1	Adenosine receptor antagonist	Phase 2	https://conductscience.org/library/genes/140	Drugs and targets
GHSR	Growth hormone secretagogue receptor type 1	1	Ghrelin receptor agonist	Phase 2	https://conductscience.org/library/genes/2693	Drugs and targets
HTR4	5-hydroxytryptamine receptor 4	1	Serotonin 4 (5-HT4) receptor agonist	Phase 3	https://conductscience.org/library/genes/3360	Drugs and targets
NR3C1	Glucocorticoid receptor	1	Glucocorticoid receptor agonist	Phase 2	https://conductscience.org/library/genes/2908	Drugs and targets
OPRK1	Kappa-type opioid receptor	1	Kappa opioid receptor agonist	Phase 2	https://conductscience.org/library/genes/4986	Drugs and targets

1 to 10 of 20

See all 20 targets

Trials9

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00443040	Asimadoline for the Treatment of Post-Operative Ileus	Phase 2	35	2012-01-06	Post-Operative Ileus	ASIMADOLINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT03456752	Perioperative Dexamethasone on Postoperative Outcome in IBD	Phase 2	302		Inflammatory Bowel Diseases, Dexamethasone, Postoperative Ileus, Postoperative Complications	DEXAMETHASONE	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT05001763	Prucalopride for Postoperative Ileus in Patients Undergoing Robot-assisted Laparoscopic Radical Cystectomy	Phase 2	160		Postoperative Ileus, Bladder Cancer	PRUCALOPRIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT02947269	Prucalopride in Postoperative Ileus	Phase 3	150		Postoperative Ileus, Colorectal Surgery, Postoperative Complications	PRUCALOPRIDE	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT02004652	Prucalopride for Postoperative Ileus in Patients Undergoing Gastrointestinal Surgery	Phase 2	110		Postoperative Ileus	PRUCALOPRIDE	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT03097900	Does Caffeine Enhance Bowel Recovery After Colorectal Surgery?	Phase 2	70		Postoperative Ileus	CAFFEINE CITRATE	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT05334485	Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery	Phase 2/3	50		Postoperative Ileus	PYRIDOSTIGMINE BROMIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT00600158	Effects of Intravenous Local Anesthetic on Bowel Function After Colectomy	Phase 3	45		Postoperative Ileus	BUPIVACAINE, HYDROMORPHONE, LIDOCAINE	Its record names the disease	ClinicalTrials.gov
NCT03386136	Therapeutic Oxygen for Gastrointestinal Atony (TOGA)	Phase 1	17		Ileus, Ogilvie Syndrome, Small Bowel Obstruction	OXYGEN	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials6

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
39131150	DERIVED	1	PubMed
35639621	DERIVED	1	PubMed
33900493	DERIVED	1	PubMed
33749741	DERIVED	1	PubMed
26880227	DERIVED	1	PubMed
20588151	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0004567

GET https://conductscience.org/api/diseases/v1/MONDO_0004567/drugs

API reference For AI assistants