Disease · MONDO_0005299

brain ischemia

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. brain ischemia. Diseases, record MONDO_0005299. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005299

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: brain ischemia; Open Targets
Open Targets ID: MONDO_0005299; Open Targets
Other names: Brain Ischemias, Cerebral Ischemias, Cerebral ischemia, Disruption of blood oxygen supply to brain, ENCEPH ISCHEMIC, Encephalopathy, Ischemic, ISCHEMIC ENCEPH, Ischemia, Brain, Ischemia, Cerebral, Ischemias, Cerebral, Ischemic Encephalopathies, Ischemic Encephalopathy, brain ischaemic disease, brain ischemic disease, cerebrovascular ischemia, ischaemic disease of brain, ischemia cerebrovascular, ischemic disease of brain; Open Targets
Disease Ontology: DOID:2316; Disease Ontology
MeSH: D002545; MeSH
NCI Thesaurus: C78394; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 2 of its 17 drugs, from ClinicalTrials.gov; Open Targets

Drugs17

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
NERINETIDE	CHEMBL502630	Protein	Phase 3	ClinicalTrials.gov	2	1	1	Drugs and targets
SODIUM LACTATE	CHEMBL1357	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
TOPIRAMATE	CHEMBL220492	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
MINOCYCLINE	CHEMBL1434	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
SOVATELITIDE	CHEMBL3188091	Protein	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
XENON	CHEMBL1236802	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
MILVEXIAN	CHEMBL4112929	Small molecule	Phase 2	TTD	1	0	0	Drugs and targets
RECOMBINANT HUMAN KALLIKREIN-1	CHEMBL4297936		Phase 2	TTD	1	0	0	Drugs and targets
RINVECALINASE ALFA	CHEMBL5314769	Enzyme	Phase 2	TTD	1	0	0	Drugs and targets
EPOETIN BETA	CHEMBL2109092	Protein	Phase 1/2	ClinicalTrials.gov	1	1	0	Drugs and targets

1 to 10 of 17

See all 17 drugs

Targets51

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADORA1	Adenosine receptor	1	Adenosine receptor antagonist	Phase 1	https://conductscience.org/library/genes/134	Drugs and targets
ADORA2A	Adenosine receptor	1	Adenosine receptor antagonist	Phase 1	https://conductscience.org/library/genes/135	Drugs and targets
ADORA2B	Adenosine receptor	1	Adenosine receptor antagonist	Phase 1	https://conductscience.org/library/genes/136	Drugs and targets
ADORA3	Adenosine receptor	1	Adenosine receptor antagonist	Phase 1	https://conductscience.org/library/genes/140	Drugs and targets
ADRA2A	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Unknown	https://conductscience.org/library/genes/150	Drugs and targets
ADRA2B	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Unknown	https://conductscience.org/library/genes/151	Drugs and targets
ADRA2C	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Unknown	https://conductscience.org/library/genes/152	Drugs and targets
AVPR1A	Vasopressin receptor	1	Vasopressin receptor agonist	Unknown	https://conductscience.org/library/genes/552	Drugs and targets
AVPR1B	Vasopressin receptor	1	Vasopressin receptor agonist	Unknown	https://conductscience.org/library/genes/553	Drugs and targets
AVPR2	Vasopressin receptor	1	Vasopressin receptor agonist	Unknown	https://conductscience.org/library/genes/554	Drugs and targets

1 to 10 of 51

See all 51 targets

Trials11

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00795366	Vasopressin Versus Catecholamines for Cerebral Perfusion Pressure Control in Brain Injured Trauma Patients	Not applicable	96	2014-12-12	Traumatic Brain Injury	VASOPRESSIN	Its record names the disease	ClinicalTrials.gov
NCT01765218	Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy	Phase 1/2	34	2024-06-11	Hypoxic Ischemic Encephalopathy	TOPIRAMATE	Open Targets' reading of its record	ClinicalTrials.gov
NCT03913221	Caffeine for Hypoxic-Ischemic Encephalopathy	Phase 1	17	2024-09-19	Hypoxic-Ischemic Encephalopathy	CAFFEINE CITRATE	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT02315443	Field Randomization of Nerinetide (NA-1) Therapy in Early Responders	Phase 3	532		Acute Cerebral Ischemia	NERINETIDE	Its record names the disease	ClinicalTrials.gov
NCT02442791	GLP-1 Analogs for Neuroprotection After Cardiac Arrest	Not applicable	120		Cardiac Arrest, Coma	EXENATIDE	Its record names the disease	ClinicalTrials.gov
NCT00879892	Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients	Phase 2	110		Ischemic Brain Injury	XENON	Its record names the disease	ClinicalTrials.gov
NCT01241019	Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia	Phase 2	64		Hypoxic Ischemic Encephalopathy	TOPIRAMATE	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT05514340	Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy	Phase 2	40		Hypoxic-Ischemic Encephalopathy, Neonatal Asphyxia, Neonatal Encephalopathy	SOVATELITIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT04876638	Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)	Phase 2	20		Aneurysm, Ruptured, Vasospasm, Intracranial, Delayed Cerebral Ischemia, Blood Brain Barrier Defect	MINOCYCLINE	Its record names the disease	ClinicalTrials.gov
NCT01687868	Evaluation of Efficacy and Safety of General Anesthesia Using Dexmedetomidine With Sevoflurane in Patients Undergoing Arthroscopic Shoulder Surgery: Preliminary Study	Not applicable	19		Arthroscopic Shoulder Surgery in the Beach-chair Position	DEXMEDETOMIDINE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

Comparisons in its trials7

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
AVP, Arginine Vasopressin vs Standard Catecholamine: serious adverse events	6 of 42	6 of 54	96	NCT00795366	Trial comparisons
Topiramate vs Placebo: deaths from any cause	0 of 17	1 of 17	34	NCT01765218	Trial comparisons
Topiramate vs Placebo: serious adverse events	0 of 17	1 of 17	34	NCT01765218	Trial comparisons
Low Dose Caffeine (5 mg/kg) vs High Dose Caffeine (10 mg/kg): Number of Participants With Necrotizing Enterocolitis	0 of 9	0 of 8	17	NCT03913221	Trial comparisons
Low Dose Caffeine (5 mg/kg) vs High Dose Caffeine (10 mg/kg): deaths from any cause	1 of 9	1 of 8	17	NCT03913221	Trial comparisons
Low Dose Caffeine (5 mg/kg) vs High Dose Caffeine (10 mg/kg): Number of Participants With Seizures Requiring >1 Anti-Epileptic Medication	1 of 9	0 of 8	17	NCT03913221	Trial comparisons
Low Dose Caffeine (5 mg/kg) vs High Dose Caffeine (10 mg/kg): serious adverse events	3 of 9	2 of 8	17	NCT03913221	Trial comparisons

Papers from its trials16

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
37587184	RESULT	1	PubMed
27838646	RESULT	1	PubMed
41298726	DERIVED	1	PubMed
39955120	DERIVED	1	PubMed
38982000	DERIVED	1	PubMed
38833442	DERIVED	1	PubMed
37548010	DERIVED	1	PubMed
36251060	DERIVED	1	PubMed
35546563	DERIVED	1	PubMed
35349976	DERIVED	1	PubMed

1 to 10 of 16

See all 16 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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