Disease · MONDO_0005473

temporomandibular joint disorder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. temporomandibular joint disorder. Diseases, record MONDO_0005473. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005473

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: temporomandibular joint disorder; Open Targets
Open Targets ID: MONDO_0005473; Open Targets
Other names: TMD; Open Targets
MeSH: D013705; MeSH
NCI Thesaurus: C63709; NCI Thesaurus
Highest stage of its drugs: Phase 2/3, for 2 of its 17 drugs, from ClinicalTrials.gov; Open Targets

Drugs17

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
IBUPROFEN	CHEMBL521	Small molecule	Phase 2/3	ClinicalTrials.gov	3	3	3	Drugs and targets
CANNABIDIOL	CHEMBL190461	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
ERENUMAB	CHEMBL3833329	Antibody	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
BENZTROPINE	CHEMBL1201203	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
NORTRIPTYLINE	CHEMBL445	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
PYRIDOXINE	CHEMBL1364	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
THIAMINE	CHEMBL1588	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
TRIAMCINOLONE HEXACETONIDE	CHEMBL1200878	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
VITAMIN B12	CHEMBL2375172		Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ASCORBIC ACID	CHEMBL196	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 17

See all 17 drugs

Targets11

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SLC6A2	Sodium-dependent noradrenaline transporter	2	Norepinephrine transporter inhibitor	Phase 2	https://conductscience.org/library/genes/6530	Drugs and targets
SLC6A4	Sodium-dependent serotonin transporter	2	Serotonin transporter inhibitor	Phase 2	https://conductscience.org/library/genes/6532	Drugs and targets
CALCRL	Calcitonin gene-related peptide type 1 receptor	1	Calcitonin gene-related peptide type 1 receptor antagonist	Phase 2	https://conductscience.org/library/genes/10203	Drugs and targets
CHRM1	Muscarinic acetylcholine receptor M1	1	Muscarinic acetylcholine receptor M1 antagonist	Phase 2	https://conductscience.org/library/genes/1128	Drugs and targets
CNR1	Cannabinoid receptor 1	1	Cannabinoid CB1 receptor negative allosteric modulator	Phase 2/3	https://conductscience.org/library/genes/1268	Drugs and targets
HTR2A	5-hydroxytryptamine receptor 2A	1	Serotonin 2a (5-HT2a) receptor antagonist	Unknown	https://conductscience.org/library/genes/3356	Drugs and targets
HTR2C	5-hydroxytryptamine receptor 2C	1	Serotonin 2c (5-HT2c) receptor antagonist	Unknown	https://conductscience.org/library/genes/3358	Drugs and targets
NR3C1	Glucocorticoid receptor	1	Glucocorticoid receptor agonist	Phase 2	https://conductscience.org/library/genes/2908	Drugs and targets
PTGS1	Cyclooxygenase	1	Cyclooxygenase inhibitor	Phase 2/3	https://conductscience.org/library/genes/5742	Drugs and targets
PTGS2	Cyclooxygenase	1	Cyclooxygenase inhibitor	Phase 2/3	https://conductscience.org/library/genes/5743	Drugs and targets

1 to 10 of 11

See all 11 targets

Trials13

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00066937	Comparison of Psychological and Pharmacological Treatments for Pain Due to Temporomandibular Joint Disorder (TMD)	Phase 2	140	2017-07-24	Temporomandibular Joint Disorders	BENZTROPINE, NORTRIPTYLINE	Its record names the disease	ClinicalTrials.gov
NCT04884763	Safety and Efficacy of Erenumab-aooe in Patients With Temporomandibular Disorder	Phase 2	30	2025-08-19	Temporomandibular Disorder	ERENUMAB	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT00981149	Duloxetine for Treatment of Painful Temporomandibular Joint Disorder	Not applicable	24	2017-11-01	Temporomandibular Joint Disorders	DULOXETINE	Its record names the disease	ClinicalTrials.gov
NCT01770912	Efficacy of Steroid Supplementation After TMJ Rinsing for Pain Management	Phase 2	24	2020-10-08	Pain	TRIAMCINOLONE HEXACETONIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT05162027	Erenumab-aooe for Temporomandibular Disorders Management: TMD Cgrp Antibody RElief (TMD CARE)	Phase 2	5	2024-04-02	Temporomandibular Disorders	ERENUMAB	Open Targets' reading of its record	ClinicalTrials.gov
NCT02602483	Exploratory Study To Assess the Efficacy and Safety of a Triple Combination for Acute Pain Treatment in Patients With Temporomandibular Joint Disorders (TMJD).	Phase 1/2	96		Temporomandibular Joint Disorders	ASCORBIC ACID, IBUPROFEN	Its record names the disease	ClinicalTrials.gov
NCT03119324	Low Level Laser Therapy in the Treatment of Temporomandibular Joint Disorders (TMJDs) Related Pain	Not applicable	90		Temporomandibular Joint Disorders	CYCLOBENZAPRINE HYDROCHLORIDE, NIMESULIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT07573137	Hard Splint Vs Conservative Therapy for TMJ Pain Management	Not applicable	60		Temporomandibular Disorders (TMDs)	IBUPROFEN	Open Targets' reading of its record	ClinicalTrials.gov
NCT05027243	Outcomes of Bilateral Temporomandibular Joint Arthroscopy and the Role of a Second Intervention - Timings and Results	Not applicable	46		Bilateral Temporomandibular Joint Disorder	INCOBOTULINUMTOXINA	Its record names the disease	ClinicalTrials.gov
NCT04775030	Methodology for Developing an Occlusal Appliance With CBD Active Carrier	Phase 2/3	40		Temporomandibular Disorder, Myofascial Pain, Cannabis, Electromyography, Occlusal Appliance, CBD	CANNABIDIOL	Its record names the disease	ClinicalTrials.gov

1 to 10 of 13

See all 13 trials

Comparisons in its trials10

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Arm A vs Arm B: deaths from any cause	0 of 15	0 of 15	30	NCT04884763	Trial comparisons
Arm A vs Arm B: serious adverse events	0 of 15	0 of 15	30	NCT04884763	Trial comparisons
Lactated Ringers vs Triamcinolone Acetonide: deaths from any cause	0 of 12	0 of 12	24	NCT01770912	Trial comparisons
Lactated Ringers vs Triamcinolone Acetonide: serious adverse events	0 of 12	0 of 12	24	NCT01770912	Trial comparisons
Lactated Ringers vs Triamcinolone Acetonide: Number of Participants With Change From Pre-Treatment Joint Sounds in 12 Weeks	4 of 10	5 of 12	22	NCT01770912	Trial comparisons
Lactated Ringers vs Triamcinolone Acetonide: Number of Participants With Change From Pre-Treatment Joint Sounds in 2 Weeks	1 of 10	5 of 12	22	NCT01770912	Trial comparisons
Lactated Ringers vs Triamcinolone Acetonide: Number of Participants With Change From Pre-Treatment Joint Sounds in 6 Weeks	3 of 10	6 of 12	22	NCT01770912	Trial comparisons
Duloxetine Study Drug vs Placebo: serious adverse events	0 of 10	0 of 9	19	NCT00981149	Trial comparisons
Erenumab-aooe vs Placebo: deaths from any cause	0 of 1	0 of 1	2	NCT05162027	Trial comparisons
Erenumab-aooe vs Placebo: serious adverse events	0 of 1	0 of 1	2	NCT05162027	Trial comparisons

Papers from its trials2

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
41070535	DERIVED	1	PubMed
40253389	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005473

GET https://conductscience.org/api/diseases/v1/MONDO_0005473/drugs

API reference For AI assistants