Disease · MONDO_0006932

pulmonary edema

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. pulmonary edema. Diseases, record MONDO_0006932. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0006932

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: pulmonary edema; Open Targets
Open Targets ID: MONDO_0006932; Open Targets
Other names: edema, pulmonary, pulmonary oedema; Open Targets
Disease Ontology: DOID:11396; Disease Ontology
MeSH: D011654; MeSH
NCI Thesaurus: C26868; NCI Thesaurus
Highest stage of its drugs: Approval, for 2 of its 9 drugs, from DailyMed; Open Targets

Drugs9

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
ETHACRYNIC ACID	CHEMBL456	Small molecule	Approval	DailyMed	2	1	1	Drugs and targets
FUROSEMIDE	CHEMBL35	Small molecule	Approval	DailyMed	2	1	1	Drugs and targets
PRAZOSIN	CHEMBL2	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
ALBUTEROL	CHEMBL714	Small molecule	Phase 2/3	ClinicalTrials.gov	2	2	2	Drugs and targets
SODIUM CHLORIDE	CHEMBL1200574	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
SILDENAFIL	CHEMBL192	Small molecule	Early phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
ACETYLCYSTEINE	CHEMBL600	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
DEXAMETHASONE	CHEMBL384467	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
NIFEDIPINE	CHEMBL193	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets11

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SLC12A1	Solute carrier family 12 member 1	2	Sodium-(potassium)-chloride cotransporter 2 inhibitor	Approval	https://conductscience.org/library/genes/6557	Drugs and targets
ADRA1A	Adrenergic receptor alpha-1	1	Adrenergic receptor alpha-1 antagonist	Phase 3	https://conductscience.org/library/genes/148	Drugs and targets
ADRA1B	Adrenergic receptor alpha-1	1	Adrenergic receptor alpha-1 antagonist	Phase 3	https://conductscience.org/library/genes/147	Drugs and targets
ADRA1D	Adrenergic receptor alpha-1	1	Adrenergic receptor alpha-1 antagonist	Phase 3	https://conductscience.org/library/genes/146	Drugs and targets
ADRB2	Beta-2 adrenergic receptor	1	Beta-2 adrenergic receptor agonist	Phase 2/3	https://conductscience.org/library/genes/154	Drugs and targets
CACNA1C	Voltage-gated L-type calcium channel	1	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/775	Drugs and targets
CACNA1D	Voltage-gated L-type calcium channel	1	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/776	Drugs and targets
CACNA1F	Voltage-gated L-type calcium channel	1	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/778	Drugs and targets
CACNA1S	Voltage-gated L-type calcium channel	1	Voltage-gated L-type calcium channel blocker	Unknown	https://conductscience.org/library/genes/779	Drugs and targets
NR3C1	Glucocorticoid receptor	1	Glucocorticoid receptor agonist	Unknown	https://conductscience.org/library/genes/2908	Drugs and targets

1 to 10 of 11

See all 11 targets

Trials7

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00310401	The Effect of Nebulized Albuterol on Donor Oxygenation	Phase 2	506	2013-09-02	Brain Death, Organ Donor, Pulmonary Edema	ALBUTEROL, SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT06188195	Establishment and Evaluation of Prenatal Prevention and Treatment Strategy for NARDS	Not applicable	500		Acute Respiratory Distress Syndrome, Respiratory Distress Syndrome, Acute	DEXAMETHASONE	Its record names the disease	ClinicalTrials.gov
NCT03945643	Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?	Early phase 1	82		Patent Foramen Ovale, Intrapulmonary Arteriovenous Anastamosis	SILDENAFIL	Its record names the disease	ClinicalTrials.gov
NCT00753064	AScVS and/ or Prazosin for Scorpion Envenomation	Phase 3	81		Scorpion Envenomation	PRAZOSIN	Its record names the disease	ClinicalTrials.gov
NCT01628731	Furosemide Versus Ethacrynic Acid in Children With Congenital Heart Disease	Phase 3	74		Fluid Overload	ETHACRYNIC ACID, FUROSEMIDE	Its record names the disease	ClinicalTrials.gov
NCT04288219	Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema	Not applicable	16		High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation, Hypoxia	NIFEDIPINE	Its record names the disease	ClinicalTrials.gov
NCT01375361	Nebulized Albuterol for Congestive Heart Failure Exacerbation	Phase 2/3	0		Congestive Heart Failure	ALBUTEROL	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Albuterol vs Saline: Number of Donor Lungs Used for Transplantation	74 of 260	78 of 246	506	NCT00310401	Trial comparisons
Albuterol vs Saline: serious adverse events	0 of 260	0 of 246	506	NCT00310401	Trial comparisons

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
25563826	DERIVED	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0006932

GET https://conductscience.org/api/diseases/v1/MONDO_0006932/drugs

API reference For AI assistants