Disease · MONDO_0007699
Hashimoto thyroiditis
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. Hashimoto thyroiditis. Diseases, record MONDO_0007699. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0007699
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
Hashimoto disease, Hashimoto hypothyroidism, Hashimoto's disease, Hashimoto's syndrome, Hashimoto's thyroiditis, Lymphocytic Thyroiditides, Lymphocytic Thyroiditis, Lymphomatous Thyroiditides, Thyroiditides, Lymphocytic, Thyroiditides, Lymphomatous, Thyroiditis, Lymphocytic, Thyroiditis, Lymphomatous, autoimmune thyroiditis, chronic lymphocytic thyroiditis
- Open Targets
Drugs14
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| PROPYLTHIOURACIL | CHEMBL1518 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| CARBIMAZOLE | CHEMBL508102 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| THYROXINE | CHEMBL42115 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| COLCHICINE | CHEMBL107 | Small molecule | Phase 2/3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| IBUPROFEN | CHEMBL521 | Small molecule | Phase 2/3 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| NAPROXEN | CHEMBL154 | Small molecule | Phase 2/3 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| PREDNISOLONE | CHEMBL131 | Small molecule | Phase 2/3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| HYDROXYCHLOROQUINE | CHEMBL1535 | Small molecule | Unknown | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| METHIMAZOLE | CHEMBL1515 | Small molecule | Unknown | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| SELENIUM | CHEMBL6068503 | Small molecule | Unknown | ClinicalTrials.gov | 2 | 2 | 1 | Drugs and targets |
1 to 10 of 14
See all 14 drugsTargets25
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| PTGS1 | Cyclooxygenase | 3 | Cyclooxygenase inhibitor | Phase 2/3 | https://conductscience.org/library/genes/5742 | Drugs and targets |
| PTGS2 | Cyclooxygenase | 3 | Cyclooxygenase inhibitor | Phase 2/3 | https://conductscience.org/library/genes/5743 | Drugs and targets |
| TPO | Thyroid peroxidase | 3 | Thyroid peroxidase inhibitor | Phase 3 | https://conductscience.org/library/genes/7173 | Drugs and targets |
| NR3C1 | Glucocorticoid receptor | 2 | Glucocorticoid receptor agonist | Phase 2/3 | https://conductscience.org/library/genes/2908 | Drugs and targets |
| DIO1 | Type I iodothyronine deiodinase | 1 | Type I iodothyronine deiodinase (Type-I 5'-deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor | Phase 3 | https://conductscience.org/library/genes/1733 | Drugs and targets |
| THRA | Thyroid hormone receptor | 1 | Thyroid hormone receptor agonist | Unknown | https://conductscience.org/library/genes/7067 | Drugs and targets |
| THRB | Thyroid hormone receptor | 1 | Thyroid hormone receptor agonist | Unknown | https://conductscience.org/library/genes/7068 | Drugs and targets |
| TLR7 | Toll-like receptor 7 | 1 | Toll-like receptor 7 antagonist | Unknown | https://conductscience.org/library/genes/51284 | Drugs and targets |
| TLR9 | Toll-like receptor 9 | 1 | Toll-like receptor 9 antagonist | Unknown | https://conductscience.org/library/genes/54106 | Drugs and targets |
| TUBA1A | Tubulin | 1 | Tubulin inhibitor | Phase 2/3 | https://conductscience.org/library/genes/7846 | Drugs and targets |
1 to 10 of 25
See all 25 targetsTrials10
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT00403390 | Generic vs. Name-Brand Levothyroxine | Not applicable | 34 | 2018-02-23 | Congenital Hypothyroidism, Hypothyroidism | LEVOTHYROXINE | Its record names the disease | ClinicalTrials.gov |
| NCT04943146 | An Assessment of Aspirin Plus Prednisone Treatment for Euthyroid Women With Thyroid Autoimmunity | 402 | Thyroid Diseases | ASPIRIN, PREDNISONE | Open Targets' reading of its record | ClinicalTrials.gov | ||
| NCT07571681 | Colchicine for Autoimmune and Subacute Thyroiditis | Phase 2/3 | 300 | Hashimoto Thyroiditis, Subacute Thyroiditis, Thyroiditis | COLCHICINE, PREDNISOLONE | Its record names the disease | ClinicalTrials.gov | |
| NCT03390582 | Gut Microbiota is Associated With Autoimmune Thyroid Disease | 200 | Gut Microbiota | METHIMAZOLE | Its record names the disease | ClinicalTrials.gov | ||
| NCT03447093 | The Oral Microbiota is Associated With Autoimmune Thyroiditis | 120 | Microbiota | METHIMAZOLE, PROPYLTHIOURACIL | Its record names the disease | ClinicalTrials.gov | ||
| NCT01436994 | Antithyroid Drug Treatment of Thyrotoxicosis in Young People | Phase 3 | 81 | Paediatric Thyrotoxicosis | CARBIMAZOLE, PROPYLTHIOURACIL, THYROXINE | Its record names the disease | ClinicalTrials.gov | |
| NCT02126683 | The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis | Not applicable | 60 | Hashimoto's Thyroiditis | HYDROXYCHLOROQUINE | Its record names the disease | ClinicalTrials.gov | |
| NCT01760421 | The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis | Not applicable | 40 | Hashimoto Thyroiditis | HYDROXYCHLOROQUINE | Its record names the disease | ClinicalTrials.gov | |
| NCT04942769 | Study on the Effect of Selenium Supplementation on the Structure and Function of Autoimmune Thyroiditis | Not applicable | 30 | Selenium | SELENIUM | Its record names the disease | ClinicalTrials.gov | |
| NCT05871957 | Adjuvant Therapeutic Effect of Vitamin D on Hashimoto's Thyroiditis | 30 | Hashimoto Thyroiditis | ERGOCALCIFEROL | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials2
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Group 1 vs Group 2: deaths from any cause | 0 of 13 | 0 of 18 | 31 | NCT00403390 | Trial comparisons |
| Group 1 vs Group 2: serious adverse events | 0 of 13 | 0 of 18 | 31 | NCT00403390 | Trial comparisons |
Papers from its trials1
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
| PMID | Listed as | Trials listing it |
|---|---|---|
| 23264396 | RESULT | 1 |
Source PubMed
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0007699
GET https://conductscience.org/api/diseases/v1/MONDO_0007699/targets?page=2