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Disease · MONDO_0008608

Targets34

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

1 to 20 of 34

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TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
TOP2ADNA topoisomerase 2-alpha3DNA topoisomerase II alpha inhibitor; DNA topoisomerase II inhibitorPhase 3https://conductscience.org/library/genes/7153Drugs and targets
ACHEAcetylcholinesterase2Acetylcholinesterase inhibitor; Cholinesterases; ACHE & BCHE inhibitorPhase 2https://conductscience.org/library/genes/43Drugs and targets
GRIN1Glutamate [NMDA] receptor2Glutamate [NMDA] receptor negative allosteric modulatorPhase 2https://conductscience.org/library/genes/2902Drugs and targets
GRIN2AGlutamate [NMDA] receptor2Glutamate [NMDA] receptor negative allosteric modulatorPhase 2https://conductscience.org/library/genes/2903Drugs and targets
GRIN2BGlutamate [NMDA] receptor2Glutamate [NMDA] receptor negative allosteric modulatorPhase 2https://conductscience.org/library/genes/2904Drugs and targets
GRIN2CGlutamate [NMDA] receptor2Glutamate [NMDA] receptor negative allosteric modulatorPhase 2https://conductscience.org/library/genes/2905Drugs and targets
GRIN2DGlutamate [NMDA] receptor2Glutamate [NMDA] receptor negative allosteric modulatorPhase 2https://conductscience.org/library/genes/2906Drugs and targets
GRIN3AGlutamate [NMDA] receptor2Glutamate [NMDA] receptor negative allosteric modulatorPhase 2https://conductscience.org/library/genes/116443Drugs and targets
GRIN3BGlutamate [NMDA] receptor2Glutamate [NMDA] receptor negative allosteric modulatorPhase 2https://conductscience.org/library/genes/116444Drugs and targets
BCHECholinesterases; ACHE & BCHE1Cholinesterases; ACHE & BCHE inhibitorPhase 1/2https://conductscience.org/library/genes/590Drugs and targets
CSF2RAGranulocyte-macrophage colony-stimulating factor receptor1Granulocyte-macrophage colony-stimulating factor receptor agonistPhase 2https://conductscience.org/library/genes/1438Drugs and targets
CSF2RBGranulocyte-macrophage colony-stimulating factor receptor1Granulocyte-macrophage colony-stimulating factor receptor agonistPhase 2https://conductscience.org/library/genes/1439Drugs and targets
GNRHRGonadotropin-releasing hormone receptor1Gonadotropin-releasing hormone receptor agonistPhase 2/3https://conductscience.org/library/genes/2798Drugs and targets
INSRInsulin receptor1Insulin receptor agonistPhase 1https://conductscience.org/library/genes/3643Drugs and targets
JAK1Janus Kinase (JAK)1Janus Kinase (JAK) inhibitorPhase 2https://conductscience.org/library/genes/3716Drugs and targets
JAK2Janus Kinase (JAK)1Janus Kinase (JAK) inhibitorPhase 2https://conductscience.org/library/genes/3717Drugs and targets
JAK3Janus Kinase (JAK)1Janus Kinase (JAK) inhibitorPhase 2https://conductscience.org/library/genes/3718Drugs and targets
POLA1DNA polymerase (alpha/delta/epsilon)1DNA polymerase (alpha/delta/epsilon) inhibitorPhase 3https://conductscience.org/library/genes/5422Drugs and targets
POLA2DNA polymerase (alpha/delta/epsilon)1DNA polymerase (alpha/delta/epsilon) inhibitorPhase 3https://conductscience.org/library/genes/23649Drugs and targets
POLD1DNA polymerase (alpha/delta/epsilon)1DNA polymerase (alpha/delta/epsilon) inhibitorPhase 3https://conductscience.org/library/genes/5424Drugs and targets

diseases-2026-09-18-0.1.0

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Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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