Disease · MONDO_0018092

Vogt-Koyanagi-Harada disease

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Vogt-Koyanagi-Harada disease. Diseases, record MONDO_0018092. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0018092

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Vogt-Koyanagi-Harada disease; Open Targets
Open Targets ID: MONDO_0018092; Open Targets
Other names: Harada's disease, Uveomenigitic syndrome, Vogt-Koyanagi syndrome, Vogt-Koyanagi-Harada disease (disorder), uveomeningoencephalitic syndrome; Open Targets
Disease Ontology: DOID:12297; Disease Ontology
MeSH: D014607; MeSH
NCI Thesaurus: C85218; NCI Thesaurus
Orphanet: ORPHA:3437; Orphanet
Highest stage of its drugs: Phase 2/3, for 1 of its 23 drugs, from ClinicalTrials.gov; Open Targets

Drugs23

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
TRIAMCINOLONE ACETONIDE	CHEMBL1504	Small molecule	Phase 2/3	ClinicalTrials.gov	2	2	1	Drugs and targets
ADALIMUMAB	CHEMBL1201580	Antibody	Unknown	ClinicalTrials.gov	3	3	3	Drugs and targets
PREDNISONE	CHEMBL635	Small molecule	Unknown	ClinicalTrials.gov	3	3	3	Drugs and targets
DEXAMETHASONE	CHEMBL384467	Small molecule	Unknown	ClinicalTrials.gov	2	2	1	Drugs and targets
METHYLPREDNISOLONE	CHEMBL650	Small molecule	Unknown	ClinicalTrials.gov	2	2	2	Drugs and targets
BETAMETHASONE	CHEMBL632	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
BETAMETHASONE DIPROPIONATE	CHEMBL1200384	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
BETAMETHASONE SODIUM PHOSPHATE	CHEMBL1200762	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
BEVACIZUMAB	CHEMBL1201583	Antibody	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
DACLIZUMAB	CHEMBL1201605	Antibody	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 23

See all 23 drugs

Targets15

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	11	Glucocorticoid receptor agonist	Phase 2/3	https://conductscience.org/library/genes/2908	Drugs and targets
IFNAR1	Interferon alpha/beta receptor	2	Interferon alpha/beta receptor agonist	Unknown	https://conductscience.org/library/genes/3454	Drugs and targets
IFNAR2	Interferon alpha/beta receptor	2	Interferon alpha/beta receptor agonist	Unknown	https://conductscience.org/library/genes/3455	Drugs and targets
TNF	Tumor necrosis factor	2	TNF-alpha inhibitor	Unknown	https://conductscience.org/library/genes/7124	Drugs and targets
DHFR	Dihydrofolate reductase	1	Dihydrofolate reductase inhibitor	Unknown	https://conductscience.org/library/genes/1719	Drugs and targets
IL17A	Interleukin-17A	1	Interleukin 17A inhibitor	Unknown	https://conductscience.org/library/genes/3605	Drugs and targets
IL1B	Interleukin-1 beta	1	Interleukin-1 beta negative allosteric modulator	Unknown	https://conductscience.org/library/genes/3553	Drugs and targets
IL2RA	Interleukin-2 receptor	1	Interleukin-2 receptor inhibitor	Unknown	https://conductscience.org/library/genes/3559	Drugs and targets
IL2RB	Interleukin-2 receptor	1	Interleukin-2 receptor inhibitor	Unknown	https://conductscience.org/library/genes/3560	Drugs and targets
IL2RG	Interleukin-2 receptor	1	Interleukin-2 receptor inhibitor	Unknown	https://conductscience.org/library/genes/3561	Drugs and targets

1 to 10 of 15

See all 15 targets

Trials9

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT03811366	Multimodal Analysis and Electroretinogram in VKH From Acute Onset - Part I	Not applicable	12	2024-11-22	Uveomeningoencephalitic Syndrome, Inflammation, Choroid Disease, Visual Impairment	METHYLPREDNISOLONE, PREDNISONE	Its record names the disease	ClinicalTrials.gov
NCT05120687	Corticosteroid Combining Noncorticosteroid Systemic Immunomodulatory Therapy in VKH		200		Vogt Koyanagi Harada Disease (VKH)	ADALIMUMAB, METHOTREXATE, PREDNISONE	Its record names the disease	ClinicalTrials.gov
NCT05349747	Outcome of Treatment of Uveitis With Biologic Drugs in Resistant Cases Vogt-koyanagi-Harada Disease		50		Uveitis	ADALIMUMAB, DACLIZUMAB, GEVOKIZUMAB, INFLIXIMAB, RITUXIMAB, SECUKINUMAB, TOCILIZUMAB	Open Targets' reading of its record	ClinicalTrials.gov
NCT03399175	Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease	Not applicable	40		Vogt Koyanagi Harada Disease	METHYLPREDNISOLONE, PREDNISONE	Its record names the disease	ClinicalTrials.gov
NCT03971279	Dexamethasone Intravitreal Implant (Ozurdex®) for Recurrent Vogt-Koyanagi-Harada (VKH) Disease Posterior Uveitis		16		Posterior Uveitis	DEXAMETHASONE	Its record names the disease	ClinicalTrials.gov
NCT05590416	A Study of Adalimumab in Acute Vogt-Koyanagi-Harada Disease		15		Vogt-Koyanagi-Harada Disease, Adalimumab	ADALIMUMAB	Its record names the disease	ClinicalTrials.gov
NCT05627739	A Study of Mycophenolate Mofetil Combined With Glucocorticoid Therapy in Relapse Vogt-Koyanagi-Harada Disease		15		Vogt-Koyanagi-Harada Disease, Mycophenolate Mofetil	MYCOPHENOLATE MOFETIL	Its record names the disease	ClinicalTrials.gov
NCT02015351	Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study	Not applicable	9		Choroidal Neovascularization	BEVACIZUMAB	Its record names the disease	ClinicalTrials.gov
NCT05031143	Suprachoroidal Triamcinolone Acetonide in Harada's Retinal Detachment	Phase 2/3	6		Vogt Koyanagi Harada Disease	TRIAMCINOLONE ACETONIDE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials19

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
27844182	RESULT	1	PubMed
27368955	RESULT	1	PubMed
27008848	RESULT	1	PubMed
25592477	RESULT	1	PubMed
24548697	RESULT	1	PubMed
24440284	RESULT	1	PubMed
23099292	RESULT	1	PubMed
22889440	RESULT	1	PubMed
21826150	RESULT	1	PubMed
21358461	RESULT	1	PubMed

1 to 10 of 19

See all 19 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0018092

GET https://conductscience.org/api/diseases/v1/MONDO_0018092/drugs?page=2

API reference For AI assistants