Disease · MONDO_0021146

headache disorder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. headache disorder. Diseases, record MONDO_0021146. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0021146

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: headache disorder; Open Targets
Open Targets ID: MONDO_0021146; Open Targets
MeSH: D020773; MeSH
Highest stage of its drugs: Phase 3, for 2 of its 8 drugs, from ClinicalTrials.gov; Open Targets

Drugs8

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
KETAMINE	CHEMBL742	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
AMITRIPTYLINE	CHEMBL629	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
PROPOFOL	CHEMBL526	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
LIDOCAINE	CHEMBL79	Small molecule	Early phase 1	ClinicalTrials.gov	3	3	3	Drugs and targets
ACETAZOLAMIDE	CHEMBL20	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
BUPIVACAINE	CHEMBL1098	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
OXYTOCIN	CHEMBL395429	Protein	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
TRIAMCINOLONE	CHEMBL1451	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets41

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SCN4A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Early phase 1	https://conductscience.org/library/genes/6329	Drugs and targets
CA1	Carbonic anhydrase 1	1	Carbonic anhydrase I inhibitor	Unknown	https://conductscience.org/library/genes/759	Drugs and targets
CA12	Carbonic anhydrase 12	1	Carbonic anhydrase XII inhibitor	Unknown	https://conductscience.org/library/genes/771	Drugs and targets
CA2	Carbonic anhydrase 2	1	Carbonic anhydrase II inhibitor	Unknown	https://conductscience.org/library/genes/760	Drugs and targets
CA4	Carbonic anhydrase 4	1	Carbonic anhydrase IV inhibitor	Unknown	https://conductscience.org/library/genes/762	Drugs and targets
GABRA1	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2554	Drugs and targets
GABRA2	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2555	Drugs and targets
GABRA3	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2556	Drugs and targets
GABRA4	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2557	Drugs and targets
GABRA5	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2558	Drugs and targets

1 to 10 of 41

See all 41 targets

Trials8

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00963040	Effect of Intranasal Oxytocin on Headache in Chronic Daily Headache	Not applicable	60	2023-06-15	Chronic Daily Headache	OXYTOCIN	Open Targets' reading of its record	ClinicalTrials.gov
NCT00203294	A Research Study to Examine the Difference Between Local Anesthetics Alone and Local Anesthetics Plus Steroids in the Treatment of Chronic Headache	Not applicable	45	2014-05-07	Migraine	BUPIVACAINE, LIDOCAINE, TRIAMCINOLONE	Open Targets' reading of its record	ClinicalTrials.gov
NCT00389038	Pediatric Chronic Headache Trial	Phase 3	132		Headache	AMITRIPTYLINE	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT06919744	Intracranial Venous Stenting Evaluation in Patients With Idiopathic Intracranial Hypertension in the Early Phase	Not applicable	114		Idiopathic Intracranial Hypertension (IIH)	ACETAZOLAMIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT05306899	Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches	Phase 3	56		Chronic Daily Headache	KETAMINE	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT06935552	Ketamine and Lidocaine Infusion in Refractory Chronic Migraine	Early phase 1	44		Refractory Chronic Migraine	KETAMINE, LIDOCAINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT06496841	Transnasal Versus Suprazygomatic SPG Block in Persistant Idiopathic Facial Pain		40		Headache, Persistent Idiopathic Facial Pain	LIDOCAINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT00228267	Propofol Injection for Daily Headache	Phase 2	28		Chronic Headache, Analgesic Rebound Headache, Chronic Daily Headache, Headache, Intractable	PROPOFOL	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov

Comparisons in its trials1

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial
GON Block Only vs GON Block Plus Steroid: serious adverse events	0 of 22	0 of 23	45	NCT00203294

Source Trial comparisons

Papers from its trials11

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
31082965	RESULT	1	PubMed
29923953	RESULT	1	PubMed
28025837	RESULT	1	PubMed
19923528	RESULT	1	PubMed
39428602	DERIVED	1	PubMed
36855160	DERIVED	1	PubMed
34028656	DERIVED	1	PubMed
28108386	DERIVED	1	PubMed
26992129	DERIVED	1	PubMed
24368463	DERIVED	1	PubMed

1 to 10 of 11

See all 11 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0021146

GET https://conductscience.org/api/diseases/v1/MONDO_0021146/targets?page=2

API reference For AI assistants