Disease · MONDO_0024575
pregnancy disorder
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. pregnancy disorder. Diseases, record MONDO_0024575. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0024575
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
- complication of pregnancy or childbirth, disorder of pregnancy, disorder of pregnancy, childbirth, or puerperium, pregnancy disease
- Open Targets
Drugs5
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| ORLISTAT | CHEMBL175247 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| INSULIN HUMAN | CHEMBL1201631 | Protein | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| METFORMIN | CHEMBL1431 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| RECOMBINANT HUMAN KALLIKREIN-1 | CHEMBL4297936 | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets | |
| RINVECALINASE ALFA | CHEMBL5314769 | Enzyme | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets54
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| COXFA4 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Unknown | https://conductscience.org/library/genes/4697 | Drugs and targets |
| COXFA4L2 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Unknown | https://conductscience.org/library/genes/56901 | Drugs and targets |
| GPD2 | Glycerol-3-phosphate dehydrogenase, mitochondrial | 1 | Mitochondrial glycerol-3-phosphate dehydrogenase inhibitor | Unknown | https://conductscience.org/library/genes/2820 | Drugs and targets |
| INSR | Insulin receptor | 1 | Insulin receptor agonist | Unknown | https://conductscience.org/library/genes/3643 | Drugs and targets |
| LIPF | Gastric triacylglycerol lipase | 1 | Gastric lipase inhibitor | Phase 2 | https://conductscience.org/library/genes/8513 | Drugs and targets |
| MT-ND1 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Unknown | https://conductscience.org/library/genes/4535 | Drugs and targets |
| MT-ND2 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Unknown | https://conductscience.org/library/genes/4536 | Drugs and targets |
| MT-ND3 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Unknown | https://conductscience.org/library/genes/4537 | Drugs and targets |
| MT-ND4 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Unknown | https://conductscience.org/library/genes/4538 | Drugs and targets |
| MT-ND4L | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Unknown | https://conductscience.org/library/genes/4539 | Drugs and targets |
1 to 10 of 54
See all 54 targetsTrials3
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT00704912 | Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women | Phase 2 | 217 | 2015-12-17 | Polycystic Ovary Syndrome | ORLISTAT | Open Targets' reading of its record | ClinicalTrials.gov |
| NCT00678080 | Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes | Not applicable | 25 | 2018-11-28 | Pregnancy Complications | INSULIN HUMAN, METFORMIN | Open Targets' reading of its record | ClinicalTrials.gov |
| NCT06875141 | DM199 for Pregnancy Complications | Not applicable | 0 | Pre-Eclampsia | RECOMBINANT HUMAN KALLIKREIN-1, RINVECALINASE ALFA | Open Targets' reading of its record | ClinicalTrials.gov |
Comparisons in its trials9
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Metformin vs Insulin: Number of Participants With Shoulder Dystocia | 1 of 8 | 0 of 13 | 21 | NCT00678080 | Trial comparisons |
| Metformin vs Insulin: Number of Participants With Fetus With Macrosomia | 0 of 8 | 1 of 13 | 21 | NCT00678080 | Trial comparisons |
| Metformin vs Insulin: Number of Participants With Hypoglycemia | 0 of 8 | 0 of 13 | 21 | NCT00678080 | Trial comparisons |
| Metformin vs Insulin: Number of Participants With Newborns Who Needed Neonatal Dextrose | 0 of 8 | 1 of 13 | 21 | NCT00678080 | Trial comparisons |
| Metformin vs Insulin: Number of Participants Who Had a Newborn With Respiratory Distress Syndrome | 1 of 8 | 3 of 13 | 21 | NCT00678080 | Trial comparisons |
| Metformin vs Insulin: Number of Participants Who Had a Cesarean Section | 4 of 8 | 6 of 13 | 21 | NCT00678080 | Trial comparisons |
| Metformin vs Insulin: serious adverse events | 0 of 8 | 0 of 13 | 21 | NCT00678080 | Trial comparisons |
| Metformin vs Insulin: The Number of Participants Who Achieved a Hemoglobin A1C <7% | 5 of 5 | 12 of 12 | 17 | NCT00678080 | Trial comparisons |
| Metformin vs Insulin: The Number of Participants Who Achieved a Hemoglobin A1C <7% | 5 of 5 | 7 of 8 | 13 | NCT00678080 | Trial comparisons |
Papers from its trials5
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0024575
GET https://conductscience.org/api/diseases/v1/MONDO_0024575/targets?page=2