Disease · MONDO_0100053

anaphylaxis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. anaphylaxis. Diseases, record MONDO_0100053. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0100053

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: anaphylaxis; Open Targets
Open Targets ID: MONDO_0100053; Open Targets
Other names: anaphylactic shock, systemic anaphylaxis; Open Targets
MeSH: D000707; MeSH
NCI Thesaurus: C107101; NCI Thesaurus
Highest stage of its drugs: Approval, for 1 of its 11 drugs, from EMA Human Drugs; Open Targets

Drugs11

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
EPINEPHRINE	CHEMBL679	Small molecule	Approval	EMA Human Drugs	6	4	4	Drugs and targets
OMALIZUMAB	CHEMBL1201589	Antibody	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
BEPOTASTINE BESYLATE	CHEMBL1201759	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
BISOPROLOL	CHEMBL645	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
CARVEDILOL	CHEMBL723	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
CLEMASTINE	CHEMBL1626	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
HEPARIN	CHEMBL4650299	Oligosaccharide	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
METOPROLOL	CHEMBL13	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
PROPRANOLOL	CHEMBL27	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
DIBUTEPINEPHRINE	CHEMBL5314457	Small molecule	Unknown	USAN	1	0	0	Drugs and targets

1 to 10 of 11

See all 11 drugs

Targets12

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADRB1	Adrenergic receptor	5	Adrenergic receptor agonist; Adrenergic receptor beta antagonist; Beta-1 adrenergic receptor antagonist	Approval	https://conductscience.org/library/genes/153	Drugs and targets
ADRB2	Adrenergic receptor	3	Adrenergic receptor agonist; Adrenergic receptor beta antagonist; Beta-2 adrenergic receptor antagonist	Approval	https://conductscience.org/library/genes/154	Drugs and targets
ADRA1A	Adrenergic receptor	2	Adrenergic receptor agonist; Adrenergic receptor alpha-1 antagonist	Approval	https://conductscience.org/library/genes/148	Drugs and targets
ADRA1B	Adrenergic receptor	2	Adrenergic receptor agonist; Adrenergic receptor alpha-1 antagonist	Approval	https://conductscience.org/library/genes/147	Drugs and targets
ADRA1D	Adrenergic receptor	2	Adrenergic receptor agonist; Adrenergic receptor alpha-1 antagonist	Approval	https://conductscience.org/library/genes/146	Drugs and targets
ADRB3	Adrenergic receptor	2	Adrenergic receptor agonist; Adrenergic receptor beta antagonist	Approval	https://conductscience.org/library/genes/155	Drugs and targets
HRH1	Histamine H1 receptor	2	Histamine H1 receptor antagonist	Unknown	https://conductscience.org/library/genes/3269	Drugs and targets
ADRA2A	Adrenergic receptor	1	Adrenergic receptor agonist	Approval	https://conductscience.org/library/genes/150	Drugs and targets
ADRA2B	Adrenergic receptor	1	Adrenergic receptor agonist	Approval	https://conductscience.org/library/genes/151	Drugs and targets
ADRA2C	Adrenergic receptor	1	Adrenergic receptor agonist	Approval	https://conductscience.org/library/genes/152	Drugs and targets

1 to 10 of 12

See all 12 targets

Trials7

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00890162	A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis	Phase 2	16	2019-07-01	Anaphylaxis, Hypotension, Bronchospasm, Angioedema	OMALIZUMAB	Its record names the disease	ClinicalTrials.gov
NCT03366298	Pharmacokinetics of Intramuscular Adrenaline in Food--Allergic Teenagers	Phase 4	12	2021-04-05	Anaphylaxis	EPINEPHRINE	Its record names the disease	ClinicalTrials.gov
NCT03826004	Clemastine in Cardiovascular Surgery	Not applicable	100		Efficacy and Safety	CLEMASTINE	Its record names the disease	ClinicalTrials.gov
NCT01887405	Comparative Evaluation of Handling Characteristics of Two Adrenaline Autoinjectors,EpiPen in Comparison With Jext	Phase 4	91		Handling of Auto-injectors	EPINEPHRINE	Its record names the disease	ClinicalTrials.gov
NCT07045701	FMXIN002 in Patients at Risk of Anaphylaxis	Phase 2/3	30		Anaphylaxis Food	EPINEPHRINE	Its record names the disease	ClinicalTrials.gov
NCT01432522	A Study for Absorption of Intranasal Epinephrine Compared to Conventional Intramuscular Epinephrine	Not applicable	12		Anaphylaxis	EPINEPHRINE	Its record names the disease	ClinicalTrials.gov
NCT00657228	Intravenous Heparin as an Adjunct for the Treatment of Anaphylactic Reactions in an Emergency Department	Not applicable	0		Anaphylaxis	HEPARIN	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Omalizumab vs Placebo: deaths from any cause	0 of 8	0 of 8	16	NCT00890162	Trial comparisons
Omalizumab vs Placebo: serious adverse events	3 of 8	2 of 8	16	NCT00890162	Trial comparisons

Papers from its trials5

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
16461140	RESULT	1	PubMed
11692118	RESULT	1	PubMed
11061773	RESULT	1	PubMed
3782679	RESULT	1	PubMed
36794963	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0100053

GET https://conductscience.org/api/diseases/v1/MONDO_0100053/drugs

API reference For AI assistants