Drug · CHEMBL679

EPINEPHRINE

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. EPINEPHRINE. Drugs and targets, record CHEMBL679. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL679

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Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: EPINEPHRINE; ChEMBL
ChEMBL ID: CHEMBL679; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Adren co, Adrenaclick, Adrenalin, Ana-guard, Ana-kit, Anapen, Anaphylactic shock drug kit, Asma-vydrin, Asthmahaler, Auvi-q, Bronkaid mist, Brovon, Emerade, Epi e z pen jr, Epinephrine (copackaged), Epinephrine component of duranest, Epinephrine component of iontocaine, Epinephrine component of lidosite topical system kit, Epinephrine component of octocaine, Epipen, Epipen e z pen, Epipen jr, Epipen jr., Eppy, Gppe inh soln, Jext, Neffy, Primatene, Primatene mist, Riddobron, Riddofan, Rybarvin, Simplene, Soln made to rybarvin for, Sus-phrine, Sus-phrine sulfite free, Sus-phrine sulfite-free, Symjepi, Twinject 0.15, Twinject 0.3; ChEMBL
Other names: (-)-(r)-epinephrine, (-)-epinephrine, Adrenaline, Adrenalinum, Epinefrina, Epinephrine hcl, Epinephrine hydrochloride, Epinephrinum, Glauposine, L-epinephrine hydrochloride, NSC-62786, Neffy, Nephridine, Racepinefrine hydrochloride, (r)-, Racepinefrine, (r)-, Sus-phrine sulphite-free, Susphrine, Tonogen, Twinject; ChEMBL
Other form: EPINEPHRINE BITARTRATE, CHEMBL1256958; Drugs and targets
Other form: EPINEPHRINE HYDROCHLORIDE, CHEMBL3183376; Drugs and targets
DrugBank: DB00668; DrugBank
InChIKey: UCTWMZQNUQWSLP-VIFPVBQESA-N; ChEMBL
Open Targets' highest stage: Approval, for 19 of its 63 diseases, from ATC, DailyMed, EMA Human Drugs and TTD; Open Targets

Targets9

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
ADRA1A	Adrenergic receptor	Adrenergic receptor agonist	AGONIST	https://conductscience.org/library/genes/148
ADRA1B	Adrenergic receptor	Adrenergic receptor agonist	AGONIST	https://conductscience.org/library/genes/147
ADRA1D	Adrenergic receptor	Adrenergic receptor agonist	AGONIST	https://conductscience.org/library/genes/146
ADRA2A	Adrenergic receptor	Adrenergic receptor agonist	AGONIST	https://conductscience.org/library/genes/150
ADRA2B	Adrenergic receptor	Adrenergic receptor agonist	AGONIST	https://conductscience.org/library/genes/151
ADRA2C	Adrenergic receptor	Adrenergic receptor agonist	AGONIST	https://conductscience.org/library/genes/152
ADRB1	Adrenergic receptor	Adrenergic receptor agonist	AGONIST	https://conductscience.org/library/genes/153
ADRB2	Adrenergic receptor	Adrenergic receptor agonist	AGONIST	https://conductscience.org/library/genes/154
ADRB3	Adrenergic receptor	Adrenergic receptor agonist	AGONIST	https://conductscience.org/library/genes/155

Source ChEMBL

Diseases63

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
Pain	Phase 3	ClinicalTrials.gov	14	14	https://conductscience.org/library/drugs?q=HP_0012531
cardiac arrest	Phase 3	ClinicalTrials.gov	11	11	https://conductscience.org/library/drugs?q=EFO_0009492
bronchiolitis	Phase 3	ClinicalTrials.gov	10	10	https://conductscience.org/library/drugs?q=MONDO_0002465
asthma	Approval	DailyMed	25	6	https://conductscience.org/library/drugs?q=MONDO_0004979
hemorrhage	Approval	ATC	7	6	https://conductscience.org/library/drugs?q=MP_0001914
anaphylaxis	Approval	EMA Human Drugs	6	4	https://conductscience.org/library/drugs?q=MONDO_0100053
septic shock	Approval	DailyMed	7	3	https://conductscience.org/library/drugs?q=EFO_0006834
hypotensive disorder	Phase 2	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=MONDO_0005468
acute myocardial infarction	Unknown	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=MONDO_0004781
chronic rhinosinusitis	Phase 1/2	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=MONDO_0006031

1 to 10 of 63Source Open Targets

See all 63 diseases

Trials337

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT02726620	Decision Support for Intraoperative Low Blood Pressure		22,435	2019-05-16	epinephrine	Its name	ClinicalTrials.gov
NCT02116309	Randomized Trial of Rectal Indomethacin and Papillary Spray of Epinephrine Versus Rectal Indomethacin to Prevent Post-ERCP Pancreatitis		948	2017-11-01	epinephrine	Its name	ClinicalTrials.gov
NCT00358579	Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest	Phase 3	727	2011-08-09	adrenaline	Its name	ClinicalTrials.gov
NCT03323736	In-Office Tympanostomy Tube Placement in Children (OTTER)	Phase 3	370	2020-01-31	epinephrine	Its name	ClinicalTrials.gov
NCT02543801	A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty	Phase 4	239	2019-10-18	epinephrine	Its name	ClinicalTrials.gov
NCT01042093	Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)		160	2013-11-08	epinephrine	Its name	ClinicalTrials.gov
NCT01163214	Management of Postoperative Pain After Total Knee Replacement.	Phase 4	160	2014-11-05	epinephrine	Its name	ClinicalTrials.gov
NCT00562627	Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty	Phase 4	102	2011-08-08	adrenaline	Its name	ClinicalTrials.gov
NCT02793947	Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures	Phase 4	102	2018-04-05	epinephrine	Its name	ClinicalTrials.gov
NCT00901628	Periarticular Multimodal Drug Injections in Total Knee Arthroplasty	Phase 4	101	2013-01-25	epinephrine	Its name	ClinicalTrials.gov

1 to 10 of 337

See all 337 trials

Comparisons in its trials110

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Hypotension Decision Support vs Usual Care Group: deaths from any cause	158 of 4,972	534 of 17,463	22,435	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: serious adverse events	541 of 4,972	1,811 of 17,463	22,435	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 50 mmHg for > 20 Minutes	85 of 4,328	304 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Glycopyrrolate	1,257 of 4,328	11,093 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Ephinephrine	409 of 4,328	1,215 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 60 mmHg	3,798 of 4,328	13,779 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 50 mmHg for > 10 Minutes	326 of 4,328	1,159 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Phenylephrine	3,685 of 4,328	12,211 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: In-hospital Mortality	137 of 4,328	487 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 55 mmHg	3,045 of 4,328	10,991 of 15,624	19,952	NCT02726620	Trial comparisons

1 to 10 of 110

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Papers from its trials256

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
41233154	RESULT	1	PubMed
37394178	RESULT	1	PubMed
34759690	RESULT	1	PubMed
34592949	RESULT	1	PubMed
34391560	RESULT	1	PubMed
33575000	RESULT	1	PubMed
32934988	RESULT	1	PubMed
32032273	RESULT	1	PubMed
31821418	RESULT	1	PubMed
31671251	RESULT	1	PubMed

1 to 10 of 256

See all 256 papers from its trials

Tests in its trials0

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

None in this release.

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL679

GET https://conductscience.org/api/drugs/v1/CHEMBL679/diseases?page=2

API reference For AI assistants