Disease · HP_0002013

Vomiting

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Vomiting. Diseases, record HP_0002013. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0002013

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Vomiting
Open Targets ID: HP_0002013
Other names: Emesis, Throwing up
Highest stage of its drugs: Approval, for 17 of its 68 drugs, from DailyMed, EMA Human Drugs, FDA, PMDA and TTD

Source Open Targets

Drugs68

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
GRANISETRON	CHEMBL289469	Small molecule	Approval	EMA Human Drugs	8	7	7	Drugs and targets
APREPITANT	CHEMBL1471	Small molecule	Approval	EMA Human Drugs and PMDA	8	6	6	Drugs and targets
PALONOSETRON	CHEMBL1189679	Small molecule	Approval	EMA Human Drugs	6	2	2	Drugs and targets
FOSAPREPITANT	CHEMBL1199324	Small molecule	Approval	EMA Human Drugs	3	2	2	Drugs and targets
NETUPITANT	CHEMBL206253	Small molecule	Approval	EMA Human Drugs	3	2	2	Drugs and targets
ONDANSETRON HYDROCHLORIDE	CHEMBL3186492	Small molecule	Approval	DailyMed	7	1	1	Drugs and targets
PALONOSETRON HYDROCHLORIDE	CHEMBL1720	Small molecule	Approval	DailyMed and PMDA	3	1	1	Drugs and targets
FOSAPREPITANT DIMEGLUMINE	CHEMBL1201782	Small molecule	Approval	PMDA	2	1	1	Drugs and targets
MECLIZINE HYDROCHLORIDE	CHEMBL3989555	Small molecule	Approval	DailyMed	5	0	0	Drugs and targets
DIPHENHYDRAMINE HYDROCHLORIDE	CHEMBL1620	Small molecule	Approval	DailyMed	3	0	0	Drugs and targets

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Targets90

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
HTR3A	5-hydroxytryptamine receptor 3A	10	Serotonin 3 (5-HT3) receptor antagonist; Serotonin 3a (5-HT3a) receptor antagonist	Approval	https://conductscience.org/library/genes/3359	Drugs and targets
TACR1	Substance-P receptor	9	Neurokinin 1 receptor antagonist	Approval	https://conductscience.org/library/genes/6869	Drugs and targets
DRD2	D(2) dopamine receptor	8	D2-like dopamine receptor antagonist; D2-like dopamine receptor inverse agonist; Dopamine D2 receptor antagonist	Approval	https://conductscience.org/library/genes/1813	Drugs and targets
HRH1	Histamine H1 receptor	6	Histamine H1 receptor antagonist	Approval	https://conductscience.org/library/genes/3269	Drugs and targets
HTR2A	5-hydroxytryptamine receptor 2A	4	Serotonin 2a (5-HT2a) receptor antagonist	Phase 3	https://conductscience.org/library/genes/3356	Drugs and targets
DRD3	D2-like dopamine receptor	3	D2-like dopamine receptor antagonist; D2-like dopamine receptor inverse agonist	Phase 3	https://conductscience.org/library/genes/1814	Drugs and targets
DRD4	D2-like dopamine receptor	3	D2-like dopamine receptor antagonist; D2-like dopamine receptor inverse agonist	Phase 3	https://conductscience.org/library/genes/1815	Drugs and targets
GABRA1	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel agonist; GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2554	Drugs and targets
GABRA2	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel agonist; GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2555	Drugs and targets
GABRA3	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel agonist; GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2556	Drugs and targets

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Trials65

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 4 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02357420	Safety and Efficacy of Relamorelin Administered to Participants With Vomiting Symptoms and Moderate to Severe Diabetic Gastroparesis	Phase 2	393	2019-07-24	Diabetes Mellitus, Diabetes Mellitus Complications, Gastroparesis	RELAMORELIN	Its record names the disease	ClinicalTrials.gov
NCT01216410	Prevention of Intraoperative Nausea and Vomiting During Cesarean Section	Not applicable	306	2013-03-25	Cesarean Delivery	METOCLOPRAMIDE, ONDANSETRON, PHENYLEPHRINE	Its record names the disease	ClinicalTrials.gov
NCT01733212	Efficacy of Ginger on Intraoperative and Postoperative Nausea and Vomiting in Elective Cesarean Section Patients	Phase 2/3	239	2018-05-11	Nausea, Vomiting	GINGER	Its record names the disease	ClinicalTrials.gov
NCT01149369	Aprepitant for the Relief of Nausea in Patients With Chronic Nausea and Vomiting of Presumed Gastric Origin Trial	Phase 2	126	2019-05-08	Gastroparesis	APREPITANT	Its record names the disease	ClinicalTrials.gov
NCT01048502	Fenofibrate and Omega-3 Fatty Acid Modulation of Endotoxemia	Not applicable	100	2016-02-19	Cardiovascular Disease	FENOFIBRATE, OMEGA-3 FATTY ACIDS	Its record names the disease	ClinicalTrials.gov
NCT00787566	Phase 2 Study of Efficacy, Tolerability, and Safety of Intranasal Granisetron for Chemo-Induced Nausea and Vomiting	Phase 2	68	2011-06-21	Chemotherapy-Induced Nausea and Vomiting	GRANISETRON	Its record names the disease	ClinicalTrials.gov
NCT00590317	Ondansetron vs Prochlorperazine for Nausea and Vomiting in the Emergency Department	Phase 2	64	2014-05-19	Nausea and Vomiting	ONDANSETRON, PROCHLORPERAZINE	Its record names the disease	ClinicalTrials.gov
NCT03040726	Netupitant and Palonosetron Hydrochloride in Preventing Chronic Nausea and Vomiting in Patients With Cancer	Phase 2/3	53	2023-10-17	Malignant Neoplasm, Nausea, Vomiting	NETUPITANT, PALONOSETRON HYDROCHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT02618343	EMS Use of Isopropyl Alcohol Aromatherapy Versus Ondansetron	Not applicable	51	2021-03-24	Nausea	ISOPROPYL ALCOHOL, ONDANSETRON	Its record names the disease	ClinicalTrials.gov
NCT01031953	Fosaprepitant Dimeglumine in Treating Patients With Nausea and Vomiting Caused By Chemotherapy	Phase 1/2	34	2014-01-30	Breakthrough Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific	FOSAPREPITANT DIMEGLUMINE	Its record names the disease	ClinicalTrials.gov

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Comparisons in its trials16

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Ginger vs Placebo: Occurrence of Intra-operative and Post-operative Vomiting	30 of 116	45 of 123	239	NCT01733212	Trial comparisons
Ginger vs Placebo: deaths from any cause	0 of 116	0 of 123	239	NCT01733212	Trial comparisons
Ginger vs Placebo: serious adverse events	0 of 116	0 of 123	239	NCT01733212	Trial comparisons
Aprepitant vs Aprepitant-placebo: deaths from any cause	0 of 63	0 of 63	126	NCT01149369	Trial comparisons
Aprepitant vs Aprepitant-placebo: Number of Participants With Improvement in Nausea	29 of 63	25 of 63	126	NCT01149369	Trial comparisons
Aprepitant vs Aprepitant-placebo: serious adverse events	1 of 63	0 of 63	126	NCT01149369	Trial comparisons
Blinded Intervention gp. vs Placebo gp.: deaths from any cause	3 of 30	2 of 43	73	NCT03040726	Trial comparisons
Blinded Intervention gp. vs Placebo gp.: serious adverse events	1 of 30	3 of 43	73	NCT03040726	Trial comparisons
Prochlorperazine vs Ondansetron: serious adverse events	3 of 32	1 of 32	64	NCT00590317	Trial comparisons
Isopropyl Alcohol vs Ondansetron Group: deaths from any cause	0 of 28	0 of 23	51	NCT02618343	Trial comparisons

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Papers from its trials28

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
37539996	RESULT	1	PubMed
34400961	RESULT	1	PubMed
32931400	RESULT	1	PubMed
32568452	RESULT	1	PubMed
30246876	RESULT	1	PubMed
28325253	RESULT	1	PubMed
26768437	RESULT	1	PubMed
22739139	RESULT	1	PubMed
42493725	DERIVED	1	PubMed
42090154	DERIVED	1	PubMed

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0002013

GET https://conductscience.org/api/diseases/v1/HP_0002013/drugs?page=2

API reference For AI assistants