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Disease · HP_0002018

Nausea

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. Nausea. Diseases, record HP_0002018. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0002018

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
Nausea
Open Targets ID
HP_0002018
Highest stage of its drugs
Approval, for 32 of its 88 drugs, from ATC, DailyMed, EMA Human Drugs, PMDA and TTD

Source Open Targets

Drugs88

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
ONDANSETRONCHEMBL46Small moleculeApprovalATC and DailyMed191616Drugs and targets
GRANISETRONCHEMBL289469Small moleculeApprovalATC and DailyMed1077Drugs and targets
METOCLOPRAMIDECHEMBL86Small moleculeApprovalTTD877Drugs and targets
APREPITANTCHEMBL1471Small moleculeApprovalATC, DailyMed, PMDA and TTD1066Drugs and targets
DRONABINOLCHEMBL465Small moleculeApprovalATC652Drugs and targets
PALONOSETRONCHEMBL1189679Small moleculeApprovalATC, EMA Human Drugs and TTD933Drugs and targets
SCOPOLAMINECHEMBL569713Small moleculeApprovalATC and TTD522Drugs and targets
GRANISETRON HYDROCHLORIDECHEMBL1237080Small moleculeApprovalDailyMed322Drugs and targets
NETUPITANTCHEMBL206253Small moleculeApprovalEMA Human Drugs322Drugs and targets
PROCHLORPERAZINECHEMBL728Small moleculeApprovalTTD322Drugs and targets

1 to 10 of 88

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Targets95

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
HTR3A5-hydroxytryptamine receptor 3A11Serotonin 3 (5-HT3) receptor antagonist; Serotonin 3a (5-HT3a) receptor antagonistApprovalhttps://conductscience.org/library/genes/3359Drugs and targets
HRH1Histamine H1 receptor9Histamine H1 receptor antagonistApprovalhttps://conductscience.org/library/genes/3269Drugs and targets
DRD2D(2) dopamine receptor8D2-like dopamine receptor antagonist; D2-like dopamine receptor inverse agonist; Dopamine D2 receptor antagonist; Dopamine D2 receptor modulatorApprovalhttps://conductscience.org/library/genes/1813Drugs and targets
TACR1Substance-P receptor8Neurokinin 1 receptor antagonistApprovalhttps://conductscience.org/library/genes/6869Drugs and targets
OPRM1Mu-type opioid receptor7Mu opioid receptor agonist; Opioid receptors; mu/kappa/delta agonist; Opioid receptors; mu/kappa/delta antagonistPhase 2/3https://conductscience.org/library/genes/4988Drugs and targets
HTR2A5-hydroxytryptamine receptor 2A4Serotonin 2a (5-HT2a) receptor antagonistApprovalhttps://conductscience.org/library/genes/3356Drugs and targets
PTGS2Cyclooxygenase4Cyclooxygenase inhibitor; Cyclooxygenase-2 inhibitorApprovalhttps://conductscience.org/library/genes/5743Drugs and targets
CNR1Cannabinoid receptor 13Cannabinoid CB1 receptor agonist; Cannabinoid CB1 receptor negative allosteric modulatorApprovalhttps://conductscience.org/library/genes/1268Drugs and targets
DRD3D2-like dopamine receptor3D2-like dopamine receptor antagonist; D2-like dopamine receptor inverse agonistApprovalhttps://conductscience.org/library/genes/1814Drugs and targets
DRD4D2-like dopamine receptor3D2-like dopamine receptor antagonist; D2-like dopamine receptor inverse agonistApprovalhttps://conductscience.org/library/genes/1815Drugs and targets

1 to 10 of 95

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Trials75

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 4 more are not shown, since the checks do not confirm them.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT00724815The Efficacy and Tolerability of NP101 Patch in the Treatment of Acute MigrainePhase 35302013-05-07Migraine DisordersSUMATRIPTANIts record names the diseaseClinicalTrials.gov
NCT01859715Emergency Department (ED) Drug Interaction in Emergency Department PatientsNot applicable5022016-05-05Drug InteractionsHYDROCODONE, ONDANSETRON, OXYCODONEIts record names the diseaseClinicalTrials.gov
NCT01216410Prevention of Intraoperative Nausea and Vomiting During Cesarean SectionNot applicable3062013-03-25Cesarean DeliveryMETOCLOPRAMIDE, ONDANSETRON, PHENYLEPHRINEIts record names the diseaseClinicalTrials.gov
NCT01733212Efficacy of Ginger on Intraoperative and Postoperative Nausea and Vomiting in Elective Cesarean Section PatientsPhase 2/32392018-05-11Nausea, VomitingGINGERIts record names the diseaseClinicalTrials.gov
NCT01718873Optimization of Bevacizumab Scheduling With Chemotherapy for Metastatic Colorectal CancerPhase 32302023-04-12Colorectal CancerBEVACIZUMAB, CAPECITABINE, FLUOROURACIL, OXALIPLATINIts record names the diseaseClinicalTrials.gov
NCT05291598Meloxicam for Pain Management After Total Joint Arthroplasty (TJA)Phase 32232024-08-14Total Knee Replacement, Total Hip ReplacementKETOROLAC, MELOXICAMIts record names the diseaseClinicalTrials.gov
NCT00655642Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult EDNot applicable1712011-05-09NauseaMETOCLOPRAMIDE, ONDANSETRON, PROMETHAZINEIts record names the diseaseClinicalTrials.gov
NCT02789410Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean DeliveryNot applicable1342019-04-25Analgesia, Obstetrical, Obstetric Surgical ProceduresHYDROMORPHONE, MORPHINEIts record names the diseaseClinicalTrials.gov
NCT01149369Aprepitant for the Relief of Nausea in Patients With Chronic Nausea and Vomiting of Presumed Gastric Origin TrialPhase 21262019-05-08GastroparesisAPREPITANTIts record names the diseaseClinicalTrials.gov
NCT01048502Fenofibrate and Omega-3 Fatty Acid Modulation of EndotoxemiaNot applicable1002016-02-19Cardiovascular DiseaseFENOFIBRATE, OMEGA-3 FATTY ACIDSIts record names the diseaseClinicalTrials.gov

1 to 10 of 75

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Comparisons in its trials33

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
NP101 Patch vs Placebo Patch: serious adverse events0 of 2340 of 235469NCT00724815Trial comparisons
NP101 Patch vs Placebo Patch: Photophobia Free at Two Hours116 of 22683 of 228454NCT00724815Trial comparisons
NP101 Patch vs Placebo Patch: Pain Free at Two Hours40 of 22621 of 228454NCT00724815Trial comparisons
NP101 Patch vs Placebo Patch: Nausea Free at Two Hours189 of 226144 of 228454NCT00724815Trial comparisons
NP101 Patch vs Placebo Patch: Phonophobia Free at Two Hours125 of 22689 of 228454NCT00724815Trial comparisons
Ginger vs Placebo: Occurrence of Intra-operative and Post-operative Vomiting30 of 11645 of 123239NCT01733212Trial comparisons
Ginger vs Placebo: deaths from any cause0 of 1160 of 123239NCT01733212Trial comparisons
Ginger vs Placebo: serious adverse events0 of 1160 of 123239NCT01733212Trial comparisons
Bevacizumab Before Chemotherapy vs Bevacizumab With Chemotherapy: Objective Response Rate65 of 11566 of 115230NCT01718873Trial comparisons
Bevacizumab Before Chemotherapy vs Bevacizumab With Chemotherapy: deaths from any cause2 of 1152 of 115230NCT01718873Trial comparisons

1 to 10 of 33

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Papers from its trials46

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
39726772RESULT1PubMed
39711135RESULT1PubMed
38955285RESULT1PubMed
37539996RESULT1PubMed
34400961RESULT1PubMed
32931400RESULT1PubMed
32568452RESULT1PubMed
30246876RESULT1PubMed
28325253RESULT1PubMed
26830816RESULT1PubMed

1 to 10 of 46

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Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0002018

GET https://conductscience.org/api/diseases/v1/HP_0002018/drugs?page=2

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