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Disease · HP_0003418

Back pain

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. Back pain. Diseases, record HP_0003418. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0003418

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
Back pain
Open Targets ID
HP_0003418
Highest stage of its drugs
Approval, for 16 of its 46 drugs, from DailyMed and TTD

Source Open Targets

Drugs46

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
NAPROXENCHEMBL154Small moleculeApprovalDailyMed533Drugs and targets
LIDOCAINECHEMBL79Small moleculeApprovalDailyMed1322Drugs and targets
MENTHOLCHEMBL256087Small moleculeApprovalDailyMed3711Drugs and targets
CAPSAICINCHEMBL294199Small moleculeApprovalDailyMed2611Drugs and targets
ACETAMINOPHENCHEMBL112Small moleculeApprovalDailyMed1311Drugs and targets
METHYL SALICYLATECHEMBL108545Small moleculeApprovalDailyMed1310Drugs and targets
IBUPROFENCHEMBL521Small moleculeApprovalDailyMed911Drugs and targets
PELUBIPROFENCHEMBL69308Small moleculeApprovalTTD211Drugs and targets
CAMPHORCHEMBL15768Small moleculeApprovalDailyMed700Drugs and targets
ASPIRINCHEMBL25Small moleculeApprovalDailyMed300Drugs and targets

1 to 10 of 46

See all 46 drugs

Targets55

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
PTGS2Cyclooxygenase12Cyclooxygenase inhibitor; Cyclooxygenase-2 inhibitorApprovalhttps://conductscience.org/library/genes/5743Drugs and targets
PTGS1Cyclooxygenase11Cyclooxygenase inhibitorApprovalhttps://conductscience.org/library/genes/5742Drugs and targets
OPRM1Mu-type opioid receptor6Mu opioid receptor agonist; Opioid receptors; mu/kappa/delta agonist; Opioid receptors; mu/kappa/delta antagonistPhase 3https://conductscience.org/library/genes/4988Drugs and targets
OPRK1Kappa-type opioid receptor5Kappa opioid receptor agonist; Opioid receptors; mu/kappa/delta agonist; Opioid receptors; mu/kappa/delta antagonistPhase 3https://conductscience.org/library/genes/4986Drugs and targets
OPRD1Delta-type opioid receptor4Delta opioid receptor agonist; Opioid receptors; mu/kappa/delta agonist; Opioid receptors; mu/kappa/delta antagonistPhase 2https://conductscience.org/library/genes/4985Drugs and targets
SLC6A2Sodium-dependent noradrenaline transporter3Norepinephrine transporter inhibitor; Norepinephrine transporter releasing agentPhase 3https://conductscience.org/library/genes/6530Drugs and targets
HRH1Histamine H1 receptor2Histamine H1 receptor antagonistApprovalhttps://conductscience.org/library/genes/3269Drugs and targets
SCN10ASodium channel alpha subunit2Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6336Drugs and targets
SCN11ASodium channel alpha subunit2Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/11280Drugs and targets
SCN1ASodium channel alpha subunit2Sodium channel alpha subunit blockerApprovalhttps://conductscience.org/library/genes/6323Drugs and targets

1 to 10 of 55

See all 55 targets

Trials22

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT02700815Capsaicin + Diclofenac Gel in Acute Back Pain or Neck PainPhase 37462019-05-06Acute PainCAPSAICIN, DICLOFENACIts record names the diseaseClinicalTrials.gov
NCT00964886Efficacy of Antidepressants in Chronic Back PainPhase 21422016-11-29Back PainBENZTROPINE MESYLATE, DESIPRAMINEIts record names the diseaseClinicalTrials.gov
NCT00315445The Safety and Efficacy of the Buprenorphine Transdermal System (BTDS) in Subjects With Chronic Back Pain.Phase 31342011-08-10Back PainBUPRENORPHINE, OXYCODONEIts record names the diseaseClinicalTrials.gov
NCT02736890Injecting Botulinum Toxin A Underneath the Skin to Treat Spinal Cord Pain in Patients With Spinal Cord InjuryPhase 282019-04-09Neuropathic Back Pain, Spinal Cord InjuryONABOTULINUMTOXINAIts record names the diseaseClinicalTrials.gov
NCT06476392Melatonin fOr CHronic bAck Pain (The MOCHA Trial)Phase 3220Back Pain Lower Back Chronic, InsomniaMELATONINIts record names the diseaseClinicalTrials.gov
NCT07475663Counterpain PXM Versus Diclofenac Versus PiroxicamPhase 3180Ankle Sprain, Back Pain, Osteoarthritis (OA) of the Knee, Tennis Elbow, Runner's KneeDICLOFENAC SODIUM, PIROXICAMIts record names the diseaseClinicalTrials.gov
NCT02375633Phase 3 Study of DW-330SR2 and Pelubiprofen in Chronic Back Pain PatientsPhase 3166Chronic Back PainPELUBIPROFENIts record names the diseaseClinicalTrials.gov
NCT00018200Effect of Antidepressants on Back PainPhase 2130Back Pain, SciaticaDESIPRAMINE, FLUOXETINEIts record names the diseaseClinicalTrials.gov
NCT01468025Effectiveness of Theramine on Chronic Back PainPhase 3127Low Back PainNAPROXENIts record names the diseaseClinicalTrials.gov
NCT01490905A Double Blind Placebo Study to Determine the Effectiveness of Theramine on the Management of Chronic Back PainPhase 4127Chronic Low Back PainIBUPROFENIts record names the diseaseClinicalTrials.gov

1 to 10 of 22

See all 22 trials

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Botulinum Toxin A vs Placebo: deaths from any cause0 of 80 of 816NCT02736890Trial comparisons
Botulinum Toxin A vs Placebo: serious adverse events1 of 80 of 816NCT02736890Trial comparisons

Papers from its trials7

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
36686276RESULT1PubMed
27382251RESULT1PubMed
17414235RESULT1PubMed
41250112DERIVED1PubMed
33688228DERIVED1PubMed
32221866DERIVED1PubMed
32068667DERIVED1PubMed

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0003418

GET https://conductscience.org/api/diseases/v1/HP_0003418/drugs?page=2

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