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Disease · HP_0012735

Cough

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. Cough. Diseases, record HP_0012735. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0012735

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
Cough
Open Targets ID
HP_0012735
Other names
Coughing
Highest stage of its drugs
Approval, for 55 of its 107 drugs, from ATC, DailyMed, EMA Human Drugs, FDA and TTD

Source Open Targets

Drugs107

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
GEFAPIXANTCHEMBL3716057Small moleculeApprovalATC and EMA Human Drugs141010Drugs and targets
GUAIFENESINCHEMBL980Small moleculeApprovalDailyMed7444Drugs and targets
DEXTROMETHORPHAN HYDROBROMIDECHEMBL1256818Small moleculeApprovalDailyMed11011Drugs and targets
BENZONATATECHEMBL1374379Small moleculeApprovalATC, DailyMed, FDA and TTD6211Drugs and targets
MENTHOLCHEMBL256087Small moleculeApprovalDailyMed4011Drugs and targets
CAMPHORCHEMBL15768Small moleculeApprovalDailyMed1911Drugs and targets
CODEINECHEMBL485Small moleculeApprovalATC311Drugs and targets
DEXTROMETHORPHANCHEMBL52440Small moleculeApprovalATC and TTD311Drugs and targets
LEVODROPROPIZINECHEMBL1288810Small moleculeApprovalATC and TTD311Drugs and targets
PHENYLEPHRINE HYDROCHLORIDECHEMBL1200339Small moleculeApprovalDailyMed5200Drugs and targets

1 to 10 of 107

See all 107 drugs

Targets72

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
OPRM1Mu-type opioid receptor8Mu opioid receptor agonist; Opioid receptors; mu/kappa/delta agonistApprovalhttps://conductscience.org/library/genes/4988Drugs and targets
HRH1Histamine H1 receptor7Histamine H1 receptor antagonist; Histamine H1 receptor inverse agonistApprovalhttps://conductscience.org/library/genes/3269Drugs and targets
GRIN2AGlutamate [NMDA] receptor4Glutamate [NMDA] receptor negative allosteric modulator; Glutamate [NMDA] receptor subunit epsilon 1 antagonistApprovalhttps://conductscience.org/library/genes/2903Drugs and targets
OPRD1Opioid receptors; mu/kappa/delta4Opioid receptors; mu/kappa/delta agonistApprovalhttps://conductscience.org/library/genes/4985Drugs and targets
OPRK1Opioid receptors; mu/kappa/delta4Opioid receptors; mu/kappa/delta agonistApprovalhttps://conductscience.org/library/genes/4986Drugs and targets
PTGS1Cyclooxygenase4Cyclooxygenase inhibitorApprovalhttps://conductscience.org/library/genes/5742Drugs and targets
PTGS2Cyclooxygenase4Cyclooxygenase inhibitorApprovalhttps://conductscience.org/library/genes/5743Drugs and targets
SLC6A2Sodium-dependent noradrenaline transporter4Norepinephrine transporter inhibitor; Norepinephrine transporter releasing agentApprovalhttps://conductscience.org/library/genes/6530Drugs and targets
ATP4APotassium-transporting ATPase3Potassium-transporting ATPase inhibitorPhase 2https://conductscience.org/library/genes/495Drugs and targets
ATP4BPotassium-transporting ATPase3Potassium-transporting ATPase inhibitorPhase 2https://conductscience.org/library/genes/496Drugs and targets

1 to 10 of 72

See all 72 targets

Trials56

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT03449147A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030)Phase 31,3172021-09-02Chronic CoughGEFAPIXANTOpen Targets' reading of its recordClinicalTrials.gov
NCT03449134A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027)Phase 37322021-06-16Chronic CoughGEFAPIXANTOpen Targets' reading of its recordClinicalTrials.gov
NCT03725085
Study to Evaluate the Safety and Tolerability of Mucinex™(Guaifenesin) 600 mg Extended-Release Bi-Layer Tablets in the Treatment of Otherwise Healthy Patients With Symptoms of Cough, Thickened Mucus and Chest Congestion
Phase 45522019-03-19Healthy SubjectsGUAIFENESINIts record names the diseaseClinicalTrials.gov
NCT04193202Efficacy and Safety of Gefapixant (MK-7264) in Adult Participants With Recent Onset Chronic Cough (MK-7264-043)Phase 34192022-10-14Chronic CoughGEFAPIXANTOpen Targets' reading of its recordClinicalTrials.gov
NCT04193176Efficacy and Safety of Gefapixant (MK-7264) in Women With Chronic Cough and Stress Urinary Incontinence (MK-7264-042)Phase 33762023-09-22Chronic CoughGEFAPIXANTOpen Targets' reading of its recordClinicalTrials.gov
NCT02993822A Dose-ranging Study of Orvepitant in Patients With Chronic Refractory CoughPhase 23152022-04-26Chronic Refractory CoughORVEPITANTIts record names the diseaseClinicalTrials.gov
NCT06716645A Clinical Evidence Study Evaluating Quality of Life Parameters Following Treatment With RobitussinPhase 42442026-02-20Common Cold, CoughDEXTROMETHORPHANIts record names the diseaseClinicalTrials.gov
NCT03696108A Study of Gefapixant (MK-7264) in Japanese Adult Participants With Refractory or Unexplained Chronic Cough (MK-7264-038)Phase 31752021-11-01Chronic CoughGEFAPIXANTIts record names the diseaseClinicalTrials.gov
NCT04525885A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030)-China ExtensionPhase 31612023-10-02Chronic CoughGEFAPIXANTIts record names the diseaseClinicalTrials.gov
NCT01257542Acute Cough Study In ChildrenPhase 41402012-09-20Common Cold, Infections, Upper Respiratory TractDEXTROMETHORPHAN HYDROBROMIDEIts record names the diseaseClinicalTrials.gov

1 to 10 of 56

See all 56 trials

Comparisons in its trials20

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Gefapixant vs Placebo: deaths from any cause0 of 2081 of 211419NCT04193202Trial comparisons
Gefapixant vs Placebo: serious adverse events3 of 2064 of 209415NCT04193202Trial comparisons
Gefapixant vs Placebo: deaths from any cause0 of 1860 of 190376NCT04193176Trial comparisons
Gefapixant vs Placebo: serious adverse events3 of 1852 of 190375NCT04193176Trial comparisons
Robitussin Cough Syrup (Daytime) vs Robitussin Cough Syrup (Daytime) + Robitussin Cough Syrup (Nighttime): deaths from any cause0 of 1150 of 112227NCT06716645Trial comparisons
Robitussin Cough Syrup (Daytime) vs Robitussin Cough Syrup (Daytime) + Robitussin Cough Syrup (Nighttime): serious adverse events0 of 1150 of 112227NCT06716645Trial comparisons
Gefapixant 15 mg BID vs Gefapixant 45 mg: Number of Participants Who Experienced at Least One Adverse Event (AE)79 of 8482 of 85169NCT03696108Trial comparisons
Gefapixant 15 mg BID vs Gefapixant 45 mg: Number of Participants Who Discontinued Study Drug Due to an AE6 of 8417 of 85169NCT03696108Trial comparisons
Gefapixant 15 mg vs Gefapixant 45 mg: deaths from any cause0 of 840 of 85169NCT03696108Trial comparisons
Gefapixant 15 mg vs Gefapixant 45 mg: serious adverse events2 of 8410 of 85169NCT03696108Trial comparisons

1 to 10 of 20

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Papers from its trials20

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
39222649RESULT1PubMed
36879087RESULT1PubMed
31054568RESULT1PubMed
23370978RESULT1PubMed
19937046RESULT1PubMed
41569557DERIVED1PubMed
38237620DERIVED1PubMed
35969360DERIVED1PubMed
35752582DERIVED1PubMed
35569802DERIVED2PubMed

1 to 10 of 20

See all 20 papers from its trials

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0012735

GET https://conductscience.org/api/diseases/v1/HP_0012735/drugs?page=2

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