Disease · HP_0031217

Hot flashes

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Hot flashes. Diseases, record HP_0031217. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0031217

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Hot flashes
Open Targets ID: HP_0031217
Highest stage of its drugs: Approval, for 3 of its 47 drugs, from EMA, EMA Human Drugs and FDA

Source Open Targets

Drugs47

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
FEZOLINETANT	CHEMBL3608680	Small molecule	Approval	EMA Human Drugs and FDA	15	12	12	Drugs and targets
ELINZANETANT	CHEMBL4802157	Small molecule	Approval	EMA Human Drugs	5	3	3	Drugs and targets
VERALIPRIDE	CHEMBL2105581	Small molecule	Approval	EMA	1	0	0	Drugs and targets
GABAPENTIN	CHEMBL940	Small molecule	Phase 3	ClinicalTrials.gov	10	10	10	Drugs and targets
ESTRADIOL	CHEMBL135	Small molecule	Phase 3	ClinicalTrials.gov	4	4	4	Drugs and targets
CYPROTERONE ACETATE	CHEMBL139835	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
OXYBUTYNIN CHLORIDE	CHEMBL1133	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
CITALOPRAM HYDROBROMIDE	CHEMBL1200781	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
ISOFLAVONE	CHEMBL366460	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
MEDROXYPROGESTERONE ACETATE	CHEMBL717	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets

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Targets53

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SLC6A4	Sodium-dependent serotonin transporter	8	Serotonin transporter inhibitor	Phase 3	https://conductscience.org/library/genes/6532	Drugs and targets
ESR1	Estrogen receptor	6	Estrogen receptor agonist; Estrogen receptor alpha agonist; Estrogen receptor alpha degrader; Estrogen receptor modulator	Phase 3	https://conductscience.org/library/genes/2099	Drugs and targets
ESR2	Estrogen receptor	5	Estrogen receptor agonist; Estrogen receptor beta agonist; Estrogen receptor modulator	Phase 2	https://conductscience.org/library/genes/2100	Drugs and targets
PGR	Progesterone receptor	4	Progesterone receptor agonist	Phase 3	https://conductscience.org/library/genes/5241	Drugs and targets
SLC6A2	Sodium-dependent noradrenaline transporter	3	Norepinephrine transporter inhibitor	Phase 3	https://conductscience.org/library/genes/6530	Drugs and targets
CACNA1A	Voltage-gated calcium channel	2	Voltage-gated calcium channel modulator	Phase 3	https://conductscience.org/library/genes/773	Drugs and targets
CACNA1B	Voltage-gated calcium channel	2	Voltage-gated calcium channel modulator	Phase 3	https://conductscience.org/library/genes/774	Drugs and targets
CACNA1C	Voltage-gated calcium channel	2	Voltage-gated calcium channel modulator	Phase 3	https://conductscience.org/library/genes/775	Drugs and targets
CACNA1D	Voltage-gated calcium channel	2	Voltage-gated calcium channel modulator	Phase 3	https://conductscience.org/library/genes/776	Drugs and targets
CACNA1E	Voltage-gated calcium channel	2	Voltage-gated calcium channel modulator	Phase 3	https://conductscience.org/library/genes/777	Drugs and targets

1 to 10 of 53

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Trials58

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01080300	Breeze3:Study of Gabapentin Extended Release in the Treatment of Vasomotor Symptoms(Hot Flashes)in Postmenopausal Women	Phase 3	600	2014-03-26	Hot Flashes	GABAPENTIN	Its record names the disease	ClinicalTrials.gov
NCT00777023	Study of Gabapentin Extended Release (G-ER)in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women.	Phase 3	565	2012-02-17	Hot Flashes	GABAPENTIN	Its record names the disease	ClinicalTrials.gov
NCT00755417	Study of Gabapentin Extended Release (G-ER) in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women	Phase 3	541	2012-03-07	Hot Flashes	GABAPENTIN	Its record names the disease	ClinicalTrials.gov
NCT04003155	A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women Going Through Menopause	Phase 3	527	2022-08-12	Hot Flashes	FEZOLINETANT	Its record names the disease	ClinicalTrials.gov
NCT05042362	A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 26 Weeks in Women Who Have Been Through the Menopause	Phase 3	396	2026-02-12	Vasomotor Symptoms Associated With Menopause, Hot Flashes	ELINZANETANT	Its record names the disease	ClinicalTrials.gov
NCT03192176	A Dose-ranging Study of the Efficacy of ESN364 in Postmenopausal Women Suffering Vasomotor Symptoms (Hot Flashes)	Phase 2	356	2021-09-29	Menopause, Hot Flashes	FEZOLINETANT	Its record names the disease	ClinicalTrials.gov
NCT01418209	MsFLASH-03: Comparative Efficacy of Low-Dose Estradiol and Venlafaxine XR for Treatment of Menopausal Symptoms	Not applicable	339	2014-08-20	Hot Flashes, Menopause, Vasomotor Disturbance	ESTRADIOL, VENLAFAXINE	Its record names the disease	ClinicalTrials.gov
NCT02961790	Oxybutynin Chloride in Managing Hot Flashes	Phase 3	150	2019-06-03	Breast Carcinoma, Ductal Breast Carcinoma In Situ, Hot Flashes, Lobular Breast Carcinoma In Situ, No Evidence of Disease	OXYBUTYNIN CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT02714205	Flushing Reduction Associated With Nitrates	Phase 2	141	2023-05-18	Menopausal Hot Flashes	NITROGLYCERIN	Its record names the disease	ClinicalTrials.gov
NCT01890109	Study of Erenumab (AMG 334) in Women With Hot Flashes	Phase 1	103	2019-01-14	Vasomotor Symptoms; Hot Flashes	ERENUMAB	Its record names the disease	ClinicalTrials.gov

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Comparisons in its trials11

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
G-ER 1800 mg vs Sugar Pill: serious adverse events	4 of 300	7 of 295	595	NCT01080300	Trial comparisons
Transdermal Nitroglycerin vs Placebo: deaths from any cause	0 of 70	0 of 71	141	NCT02714205	Trial comparisons
Transdermal Nitroglycerin vs Placebo: serious adverse events	0 of 70	0 of 71	141	NCT02714205	Trial comparisons
Transdermal Nitroglycerin vs Placebo: Number of Participants With Treatment Related Severe Adverse Events Defined by Common Terminology Criteria for Adverse Events (CTCAE) Severity Grade 3 or Higher.	0 of 66	0 of 71	137	NCT02714205	Trial comparisons
Erenumab vs Placebo: Number of Participants With Treatment-emergent Suicidal Ideation	0 of 50	0 of 52	102	NCT01890109	Trial comparisons
Erenumab 70 mg vs Placebo: serious adverse events	0 of 50	0 of 52	102	NCT01890109	Trial comparisons
Melatonin vs Placebo: Compliance	43 of 48	43 of 47	95	NCT01805089	Trial comparisons
Melatonin vs Placebo: serious adverse events	0 of 48	0 of 47	95	NCT01805089	Trial comparisons
Fezolinetant vs Placebo: deaths from any cause	0 of 43	0 of 44	87	NCT05419908	Trial comparisons
Fezolinetant vs Placebo: serious adverse events	0 of 43	1 of 44	87	NCT05419908	Trial comparisons

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Papers from its trials47

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
32328775	RESULT	1	PubMed
31415087	RESULT	1	PubMed
21271347	RESULT	1	PubMed
20498389	RESULT	1	PubMed
18375894	RESULT	1	PubMed
18202966	RESULT	1	PubMed
17487652	RESULT	1	PubMed
17453860	RESULT	1	PubMed
17146104	RESULT	1	PubMed
16505409	RESULT	1	PubMed

1 to 10 of 47

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0031217

GET https://conductscience.org/api/diseases/v1/HP_0031217/drugs?page=2

API reference For AI assistants