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Disease · MONDO_0000402

Targets129

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

1 to 20 of 129

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TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
TOP1DNA topoisomerase 13DNA topoisomerase I inhibitorApprovalhttps://conductscience.org/library/genes/7150Drugs and targets
TOP2ADNA topoisomerase 2-alpha3DNA topoisomerase II alpha inhibitor; DNA topoisomerase II inhibitorApprovalhttps://conductscience.org/library/genes/7153Drugs and targets
TUBA1ATubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/7846Drugs and targets
TUBA1BTubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/10376Drugs and targets
TUBA1CTubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/84790Drugs and targets
TUBA3CTubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/7278Drugs and targets
TUBA3ETubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/112714Drugs and targets
TUBA4ATubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/7277Drugs and targets
TUBBTubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/203068Drugs and targets
TUBB1Tubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/81027Drugs and targets
TUBB2ATubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/7280Drugs and targets
TUBB2BTubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/347733Drugs and targets
TUBB3Tubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/10381Drugs and targets
TUBB4ATubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/10382Drugs and targets
TUBB4BTubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/10383Drugs and targets
TUBB6Tubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/84617Drugs and targets
TUBB8Tubulin2Tubulin inhibitorPhase 2https://conductscience.org/library/genes/347688Drugs and targets
ADRM126S proteasome126S proteasome inhibitorPhase 1https://conductscience.org/library/genes/11047Drugs and targets
ATRSerine/threonine-protein kinase ATR1Serine-protein kinase ATR inhibitorPhase 2https://conductscience.org/library/genes/545Drugs and targets
CD274Programmed cell death 1 ligand 11Programmed cell death 1 ligand 1 inhibitorPhase 2https://conductscience.org/library/genes/29126Drugs and targets

diseases-2026-09-18-0.1.0

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Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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