Disease · MONDO_0002146
Targets15
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
1 to 15 of 15
Download this page as JSON| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| ESR1 | Estrogen receptor | 9 | Estrogen receptor agonist; Estrogen receptor alpha agonist; Estrogen receptor alpha modulator; Estrogen receptor modulator | Approval | https://conductscience.org/library/genes/2099 | Drugs and targets |
| AR | Androgen receptor | 6 | Androgen Receptor agonist | Approval | https://conductscience.org/library/genes/367 | Drugs and targets |
| GNRHR | Gonadotropin-releasing hormone receptor | 6 | Gonadotropin-releasing hormone receptor agonist; Gonadotropin-releasing hormone receptor antagonist | Phase 1/2 | https://conductscience.org/library/genes/2798 | Drugs and targets |
| ESR2 | Estrogen receptor | 3 | Estrogen receptor agonist; Estrogen receptor modulator | Approval | https://conductscience.org/library/genes/2100 | Drugs and targets |
| FSHR | Follicle-stimulating hormone receptor | 3 | Follicle stimulating hormone receptor agonist | Approval | https://conductscience.org/library/genes/2492 | Drugs and targets |
| CYP19A1 | Aromatase | 2 | Cytochrome P450 19A1 inhibitor | Phase 3 | https://conductscience.org/library/genes/1588 | Drugs and targets |
| DRD2 | D2-like dopamine receptor | 2 | D2-like dopamine receptor agonist | Approval | https://conductscience.org/library/genes/1813 | Drugs and targets |
| DRD3 | D2-like dopamine receptor | 2 | D2-like dopamine receptor agonist | Approval | https://conductscience.org/library/genes/1814 | Drugs and targets |
| DRD4 | D2-like dopamine receptor | 2 | D2-like dopamine receptor agonist | Approval | https://conductscience.org/library/genes/1815 | Drugs and targets |
| LHCGR | Lutropin-choriogonadotropic hormone receptor | 2 | Luteinizing hormone/Choriogonadotropin receptor agonist | Approval | https://conductscience.org/library/genes/3973 | Drugs and targets |
| PGR | Progesterone receptor | 2 | Progesterone receptor agonist | Approval | https://conductscience.org/library/genes/5241 | Drugs and targets |
| SRD5A2 | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 2 | Steroid 5-alpha-reductase 2 inhibitor; Steroid 5-alpha-reductase inhibitor | Phase 3 | https://conductscience.org/library/genes/6716 | Drugs and targets |
| IL1R1 | Interleukin-1 receptor type 1 | 1 | Interleukin-1 receptor antagonist | Phase 3 | https://conductscience.org/library/genes/3554 | Drugs and targets |
| SRD5A1 | Steroid 5-alpha-reductase | 1 | Steroid 5-alpha-reductase inhibitor | Phase 3 | https://conductscience.org/library/genes/6715 | Drugs and targets |
| SRD5A3 | Steroid 5-alpha-reductase | 1 | Steroid 5-alpha-reductase inhibitor | Phase 3 | https://conductscience.org/library/genes/79644 | Drugs and targets |
diseases-2026-09-18-0.1.0
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0002146/targets