Disease · MONDO_0002492

acute kidney injury

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. acute kidney injury. Diseases, record MONDO_0002492. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0002492

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: acute kidney injury; Open Targets
Open Targets ID: MONDO_0002492; Open Targets
Other names: AKI, ARF, acute kidney failure, acute renal failure, kidney failure, acute; Open Targets
Disease Ontology: DOID:3021; Disease Ontology
MeSH: D058186; MeSH
NCI Thesaurus: C26808; NCI Thesaurus
Highest stage of its drugs: Approval, for 1 of its 140 drugs, from DailyMed; Open Targets

Drugs140

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
MANNITOL	CHEMBL689	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
SODIUM CHLORIDE	CHEMBL1200574	Small molecule	Phase 3	ClinicalTrials.gov	13	13	12	Drugs and targets
NOREPINEPHRINE	CHEMBL1437	Small molecule	Phase 3	ClinicalTrials.gov	9	9	9	Drugs and targets
CITRIC ACID	CHEMBL1261	Small molecule	Phase 3	ClinicalTrials.gov	8	8	5	Drugs and targets
ALBUMIN HUMAN	CHEMBL1201451	Protein	Phase 3	ClinicalTrials.gov	7	7	7	Drugs and targets
ACETAMINOPHEN	CHEMBL112	Small molecule	Phase 3	ClinicalTrials.gov	5	5	5	Drugs and targets
HEPARIN	CHEMBL4650299	Oligosaccharide	Phase 3	ClinicalTrials.gov	5	5	4	Drugs and targets
VASOPRESSIN	CHEMBL373742	Protein	Phase 3	ClinicalTrials.gov	5	5	5	Drugs and targets
ANGIOTENSIN II	CHEMBL408403	Protein	Phase 3	ClinicalTrials.gov	4	4	4	Drugs and targets
FENOLDOPAM	CHEMBL588	Small molecule	Phase 3	ClinicalTrials.gov	4	4	4	Drugs and targets

1 to 10 of 140

See all 140 drugs

Targets209

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SCN4A	Sodium channel alpha subunit	10	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 2/3	https://conductscience.org/library/genes/6329	Drugs and targets
ADRB1	Adrenergic receptor	8	Adrenergic receptor agonist; Adrenergic receptor beta agonist; Adrenergic receptor beta antagonist; Beta-1 adrenergic receptor agonist	Phase 3	https://conductscience.org/library/genes/153	Drugs and targets
SCN10A	Sodium channel alpha subunit	8	Sodium channel alpha subunit blocker	Unknown	https://conductscience.org/library/genes/6336	Drugs and targets
SCN11A	Sodium channel alpha subunit	8	Sodium channel alpha subunit blocker	Unknown	https://conductscience.org/library/genes/11280	Drugs and targets
SCN1A	Sodium channel alpha subunit	8	Sodium channel alpha subunit blocker	Unknown	https://conductscience.org/library/genes/6323	Drugs and targets
SCN2A	Sodium channel alpha subunit	8	Sodium channel alpha subunit blocker	Unknown	https://conductscience.org/library/genes/6326	Drugs and targets
SCN3A	Sodium channel alpha subunit	8	Sodium channel alpha subunit blocker	Unknown	https://conductscience.org/library/genes/6328	Drugs and targets
SCN5A	Sodium channel alpha subunit	8	Sodium channel alpha subunit blocker	Unknown	https://conductscience.org/library/genes/6331	Drugs and targets
SCN7A	Sodium channel alpha subunit	8	Sodium channel alpha subunit blocker	Unknown	https://conductscience.org/library/genes/6332	Drugs and targets
SCN8A	Sodium channel alpha subunit	8	Sodium channel alpha subunit blocker	Unknown	https://conductscience.org/library/genes/6334	Drugs and targets

1 to 10 of 209

See all 209 targets

Trials146

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 7 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02726620	Decision Support for Intraoperative Low Blood Pressure	Not applicable	22,435	2019-05-16	Hypotension	ARTICAINE, ATROPINE, BENZOCAINE, BUPIVACAINE, CHLOROPROCAINE, DESFLURANE, DOBUTAMINE, DOPAMINE, EPHEDRINE, EPINEPHRINE, GLYCOPYRRONIUM BROMIDE, ISOFLURANE, ISOPROTERENOL, LEVOBUPIVACAINE, LIDOCAINE, MEPIVACAINE, MILRINONE, NOREPINEPHRINE, PHENYLEPHRINE, PRILOCAINE, PROCAINE, PROPOFOL, ROPIVACAINE, SEVOFLURANE, TERLIPRESSIN, TETRACAINE, VASOPRESSIN	Its record names the disease	ClinicalTrials.gov
NCT04411472	(Revival) Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated AKI	Phase 3	676	2024-06-03	Acute Kidney Injury Due to Sepsis	ILOFOTASE ALFA	Its record names the disease	ClinicalTrials.gov
NCT00791648	Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery	Not applicable	653	2017-03-06	Acute Kidney Injury, Post-Operative Delirium, Icu Delirium, Acute Renal Failure, Delirium	ATORVASTATIN	Its record names the disease	ClinicalTrials.gov
NCT02361736	Evaluate the Nephrotoxicity by 6% Hydroxyethyl Starch 130/0.4 in Old Patients During Orthopaedic Surgery	Not applicable	120	2016-03-24	Total Fluid Volume Increased	HETASTARCH	Its record names the disease	ClinicalTrials.gov
NCT02272725	Non-steroidal Anti-inflammatory Affect on Kidneys in Endurance Distances	Phase 3	91	2017-05-16	Acute Kidney Injury, Exercise-associated Hyponatremia, Perceived Exertion	IBUPROFEN	Its record names the disease	ClinicalTrials.gov
NCT00743106	The Effect of Fenoldopam in Solitary Partial Nephrectomy Surgery	Not applicable	90	2016-10-31	Partial Nephrectomy	FENOLDOPAM	Its record names the disease	ClinicalTrials.gov
NCT01709227	Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass	Not applicable	73	2017-06-09	Acute Kidney Injury	FUROSEMIDE	Its record names the disease	ClinicalTrials.gov
NCT01366976	Inhibition of Lipid Peroxidation During Cardiac Surgery	Not applicable	67	2015-01-14	Cardiopulmonary Bypass Induced Lipid Peroxidation	ACETAMINOPHEN	Its record names the disease	ClinicalTrials.gov
NCT03403751	Phase 3 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury	Phase 3	58	2021-09-16	Acute Kidney Injury, Peritonitis, Necrotizing Soft Tissue Infection	RELTECIMOD	Its record names the disease	ClinicalTrials.gov
NCT01675453	The Efficacy and Safety of Hypertonic Saline in Cardiac Surgery Patients.	Phase 2	40	2014-06-19	Coronary Artery Disease, Edema	HETASTARCH, SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 146

See all 146 trials

Comparisons in its trials55

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Hypotension Decision Support vs Usual Care Group: deaths from any cause	158 of 4,972	534 of 17,463	22,435	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: serious adverse events	541 of 4,972	1,811 of 17,463	22,435	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 50 mmHg for > 20 Minutes	85 of 4,328	304 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Glycopyrrolate	1,257 of 4,328	11,093 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Ephinephrine	409 of 4,328	1,215 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 60 mmHg	3,798 of 4,328	13,779 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 50 mmHg for > 10 Minutes	326 of 4,328	1,159 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Phenylephrine	3,685 of 4,328	12,211 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: In-hospital Mortality	137 of 4,328	487 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 55 mmHg	3,045 of 4,328	10,991 of 15,624	19,952	NCT02726620	Trial comparisons

1 to 10 of 55

See all 55 comparisons in its trials

Papers from its trials121

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
41159812	RESULT	1	PubMed
39726772	RESULT	1	PubMed
39711135	RESULT	1	PubMed
38955285	RESULT	1	PubMed
38688665	RESULT	1	PubMed
38172296	RESULT	1	PubMed
38161497	RESULT	1	PubMed
37303085	RESULT	1	PubMed
37012016	RESULT	1	PubMed
35249707	RESULT	1	PubMed

1 to 10 of 121

See all 121 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0002492

GET https://conductscience.org/api/diseases/v1/MONDO_0002492/drugs?page=2

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