Disease · MONDO_0002635

periodontal disorder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. periodontal disorder. Diseases, record MONDO_0002635. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0002635

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: periodontal disorder; Open Targets
Open Targets ID: MONDO_0002635; Open Targets
Other names: disease of periodontium, disease or disorder of periodontium, disorder of periodontium, periodontal disease, periodontium disease, periodontium disease or disorder; Open Targets
Disease Ontology: DOID:3388; Disease Ontology
MeSH: D010510; MeSH
NCI Thesaurus: C63743; NCI Thesaurus
Highest stage of its drugs: Approval, for 1 of its 39 drugs, from DailyMed; Open Targets

Drugs39

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
SODIUM MONOFLUOROPHOSPHATE	CHEMBL1908359	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
CHLORHEXIDINE	CHEMBL790	Small molecule	Phase 3	ClinicalTrials.gov	8	8	8	Drugs and targets
MINOCYCLINE	CHEMBL1434	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
TRICLOSAN	CHEMBL849	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
DOXYCYCLINE	CHEMBL1200699	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
INDOCYANINE GREEN	CHEMBL1646	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
RESVERATROL	CHEMBL165	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
SODIUM FLUORIDE	CHEMBL1528	Small molecule	Phase 3	ClinicalTrials.gov	1	1	0	Drugs and targets
ALOE	CHEMBL2108221		Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
CETYLPYRIDINIUM CHLORIDE	CHEMBL2003538	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 39

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Targets33

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
DRD2	D(2) dopamine receptor	8	D2-like dopamine receptor antagonist; Dopamine D2 receptor antagonist; Dopamine D2 receptor partial agonist; Dopamine receptors; D2 & D3 antagonist	Unknown	https://conductscience.org/library/genes/1813	Drugs and targets
HTR2A	5-hydroxytryptamine receptor 2A	8	Serotonin (5-HT) receptor antagonist; Serotonin 2a (5-HT2a) receptor antagonist	Unknown	https://conductscience.org/library/genes/3356	Drugs and targets
HTR2C	5-hydroxytryptamine receptor 2C	5	Serotonin (5-HT) receptor antagonist; Serotonin 2c (5-HT2c) receptor antagonist	Unknown	https://conductscience.org/library/genes/3358	Drugs and targets
DRD3	D2-like dopamine receptor	2	D2-like dopamine receptor antagonist; Dopamine receptors; D2 & D3 antagonist	Unknown	https://conductscience.org/library/genes/1814	Drugs and targets
HTR1A	5-hydroxytryptamine receptor 1A	2	Serotonin (5-HT) receptor antagonist; Serotonin 1a (5-HT1a) receptor partial agonist	Unknown	https://conductscience.org/library/genes/3350	Drugs and targets
AR	Androgen receptor	1	Androgen Receptor antagonist	Unknown	https://conductscience.org/library/genes/367	Drugs and targets
CNR1	Cannabinoid receptor 1	1	Cannabinoid CB1 receptor negative allosteric modulator	Phase 1	https://conductscience.org/library/genes/1268	Drugs and targets
DRD4	D2-like dopamine receptor	1	D2-like dopamine receptor antagonist	Unknown	https://conductscience.org/library/genes/1815	Drugs and targets
ESR1	Estrogen receptor	1	Estrogen receptor alpha agonist	Unknown	https://conductscience.org/library/genes/2099	Drugs and targets
HMGCR	3-hydroxy-3-methylglutaryl-coenzyme A reductase	1	HMG-CoA reductase inhibitor	Phase 2	https://conductscience.org/library/genes/3156	Drugs and targets

1 to 10 of 33

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Trials32

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00529555	Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis	Phase 3	602	2014-05-09	Adult Periodontitis	MINOCYCLINE	Its record names the disease	ClinicalTrials.gov
NCT04830969	Impact of Periodontal Therapy on Patients With Diabetes	Phase 2	116	2023-03-01	Diabetes Mellitus, Type II, Periodontitis	CHLORHEXIDINE GLUCONATE	Its record names the disease	ClinicalTrials.gov
NCT01802216	Kidney and Periodontal Disease Study	Not applicable	51	2019-04-30	Chronic Kidney Disease, Periodontal Disease	MINOCYCLINE	Its record names the disease	ClinicalTrials.gov
NCT01929135	Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status.	Phase 2	38	2014-07-28	Chronic Periodontitis	ATORVASTATIN	Its record names the disease	ClinicalTrials.gov
NCT00763256	The Effect of Periodontal Treatment and the Use of Dentifrice on Glycaemic Control in Diabetics	Phase 3	33	2012-04-02	Periodontal Disease	TRICLOSAN	Its record names the disease	ClinicalTrials.gov
NCT00763165	Periodontal Disease and Cardiovascular Disease	Phase 3	438		Periodontal Diseases	TRICLOSAN	Its record names the disease	ClinicalTrials.gov
NCT02874963	FM-SRP and Tooth Extraction Improve Type 2 Diabetes Mellitus in Periodontitis	Not applicable	160		Periodontitis, Type 2 Diabetes Mellitus	ALCOHOL	Its record names the disease	ClinicalTrials.gov
NCT05021861	Evaluation of Periodontal Status and hsCRP Levels in Females With PCOS on CPA/EE Combination Drug Regimen		150		Periodontitis, Polycystic Ovary Syndrome, Gingivitis	CYPROTERONE ACETATE, ETHINYL ESTRADIOL	Its record names the disease	ClinicalTrials.gov
NCT00371332	Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis	Phase 3	128		Periodontitis	MINOCYCLINE	Its record names the disease	ClinicalTrials.gov
NCT07175090	Evaluation of Coconut Oil Mouth Rinse on Periodontal Parameters	Early phase 1	120		Periodontitis, Adult, Mouthwash	WAX, EMULSIFYING	Its record names the disease	ClinicalTrials.gov

1 to 10 of 32

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Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Intensive Periodontal Disease Treatment vs Control/Delayed Treatment: deaths from any cause	0 of 34	0 of 17	51	NCT01802216	Trial comparisons
Intensive Periodontal Disease Treatment vs Control/Delayed Treatment: serious adverse events	1 of 34	0 of 17	51	NCT01802216	Trial comparisons
Atorvastatin Group vs Placebo Group: serious adverse events	0 of 19	0 of 19	38	NCT01929135	Trial comparisons
Active Comparator vs B - Placebo Comparator: serious adverse events	0 of 15	0 of 18	33	NCT00763256	Trial comparisons

Papers from its trials15

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
27447617	RESULT	1	PubMed
26647939	RESULT	1	PubMed
19563331	RESULT	1	PubMed
18454655	RESULT	1	PubMed
17492050	RESULT	1	PubMed
8682921	RESULT	1	PubMed
42057009	DERIVED	1	PubMed
41553854	DERIVED	1	PubMed
41328922	DERIVED	1	PubMed
39077939	DERIVED	1	PubMed

1 to 10 of 15

See all 15 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0002635

GET https://conductscience.org/api/diseases/v1/MONDO_0002635/drugs?page=2

API reference For AI assistants