Disease · MONDO_0005003

chronic pancreatitis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. chronic pancreatitis. Diseases, record MONDO_0005003. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005003

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: chronic pancreatitis; Open Targets
Open Targets ID: MONDO_0005003; Open Targets
Other names: CP - Chronic pancreatitis, Chronic pancreatitis (disorder), Pancreatitis, recurrent, Recurrent pancreatitis, Recurrent pancreatitis (disorder), Relapsing pancreatitis, Relapsing pancreatitis (disorder), chronic pancreatitis (disorder) [Ambiguous], pancreatitis, chronic; Open Targets
Disease Ontology: DOID:0051065; Disease Ontology
MeSH: D050500; MeSH
NCI Thesaurus: C84637; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 3 of its 34 drugs, from ClinicalTrials.gov; Open Targets

Drugs34

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
BUPIVACAINE	CHEMBL1098	Small molecule	Phase 3	ClinicalTrials.gov	4	4	3	Drugs and targets
PANCRELIPASE	CHEMBL2108074	Enzyme	Phase 3	ClinicalTrials.gov	4	4	2	Drugs and targets
TRIAMCINOLONE	CHEMBL1451	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
PREGABALIN	CHEMBL1059	Small molecule	Phase 2/3	ClinicalTrials.gov	2	2	2	Drugs and targets
LEVOBUPIVACAINE	CHEMBL1201193	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
CANNABINOL	CHEMBL74415	Small molecule	Phase 2	ClinicalTrials.gov	2	2	0	Drugs and targets
PIOGLITAZONE	CHEMBL595	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
BUPROPION	CHEMBL894	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
DIAZEPAM	CHEMBL12	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
DRONABINOL	CHEMBL465	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets

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Targets134

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SCN4A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6329	Drugs and targets
SCN10A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6336	Drugs and targets
SCN11A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/11280	Drugs and targets
SCN1A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6323	Drugs and targets
SCN2A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6326	Drugs and targets
SCN3A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6328	Drugs and targets
SCN5A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6331	Drugs and targets
SCN7A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6332	Drugs and targets
SCN8A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6334	Drugs and targets
SCN9A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6335	Drugs and targets

1 to 10 of 134

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Trials30

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 5 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00782795	Chronic Pancreatitis. Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life Quality	Phase 2	64	2017-12-11	Chronic Pancreatitis, Insulin Resistance, Normal or Mildly Abnormal Stool Fat Levels	PIOGLITAZONE	Its record names the disease	ClinicalTrials.gov
NCT02947087	Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis	Phase 1/2	48	2023-05-09	Chronic Pancreatitis	.ALPHA.1-PROTEINASE INHIBITOR HUMAN	Its record names the disease	ClinicalTrials.gov
NCT00658736	Efficacy of EUS-guided Celiac Plexus Blockade in Chronic Pancreatitis	Phase 3	40	2017-06-14	Chronic Pancreatitis	TRIAMCINOLONE	Its record names the disease	ClinicalTrials.gov
NCT04207060	Trial of Indomethacin in Chronic Pancreatitis	Phase 1/2	27	2024-09-04	Chronic Pancreatitis	INDOMETHACIN	Its record names the disease	ClinicalTrials.gov
NCT01142128	Viokase 16, Viokase16 Plus Nexium and Nexium Alone	Phase 1	12	2013-02-21	Chronic Pancreatitis	ESOMEPRAZOLE MAGNESIUM, PANCRELIPASE	Its record names the disease	ClinicalTrials.gov
NCT01265875	Secretin Infusion for Pain Due to Chronic Pancreatitis	Phase 1/2	12	2016-03-01	Chronic Pancreatitis	SECRETIN	Its record names the disease	ClinicalTrials.gov
NCT03283566	Hydroxychloroquine and Metabolic Outcomes in Patients Undergoing TPAIT	Phase 2	9	2022-03-11	Chronic Pancreatitis, Insulin Dependent Diabetes	HYDROXYCHLOROQUINE	Its record names the disease	ClinicalTrials.gov
NCT02693093	A Dose Ranging Study Evaluating Efficacy and Safety of NI-03	Phase 1/2	264		Chronic Pancreatitis	CAMOSTAT	Its record names the disease	ClinicalTrials.gov
NCT00583271	A Prospective Study of EUS Guided Celiac Block		127		Chronic Pancreatitis, Pancreatic Cancer	ALCOHOL, TRIAMCINOLONE	Its record names the disease	ClinicalTrials.gov
NCT07074379	Endotherapy and/or Extracorporeal Shockwave Lithotripsy for Painless Chronic Pancreatitis	Not applicable	126		Painless Chronic Pancreatitis	ACARBOSE, GLIMEPIRIDE, INSULIN HUMAN, METFORMIN, PANCREATIN	Its record names the disease	ClinicalTrials.gov

1 to 10 of 30

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Comparisons in its trials10

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Prolastin-C vs Placebo: deaths from any cause	2 of 29	0 of 14	43	NCT02947087	Trial comparisons
Prolastin-C vs Placebo: serious adverse events	22 of 29	8 of 14	43	NCT02947087	Trial comparisons
Bupivicaine and Triamcinolone vs Bupivicaine Alone: Change in Pain Disability Index	3 of 21	3 of 19	40	NCT00658736	Trial comparisons
Bupivicaine and Triamcinolone vs Bupivicaine Alone: serious adverse events	0 of 21	0 of 19	40	NCT00658736	Trial comparisons
Indomethacin vs Placebo: deaths from any cause	0 of 13	0 of 14	27	NCT04207060	Trial comparisons
Indomethacin vs Placebo: serious adverse events	0 of 13	0 of 14	27	NCT04207060	Trial comparisons
Pioglitazone vs Sugar Pill (Placebo): serious adverse events	4 of 17	2 of 8	25	NCT00782795	Trial comparisons
Pioglitazone vs Sugar Pill (Placebo): Number and Percentage of Participants With Steatorrhea	5 of 16	1 of 6	22	NCT00782795	Trial comparisons
Hydroxychloroquine vs Placebo: deaths from any cause	0 of 3	0 of 3	6	NCT03283566	Trial comparisons
Hydroxychloroquine vs Placebo: serious adverse events	0 of 3	0 of 3	6	NCT03283566	Trial comparisons

Papers from its trials63

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
38794273	RESULT	1	PubMed
31780277	RESULT	1	PubMed
31598921	RESULT	1	PubMed
31404020	RESULT	1	PubMed
31089778	RESULT	1	PubMed
30325862	RESULT	1	PubMed
30325859	RESULT	1	PubMed
29769209	RESULT	1	PubMed
29671994	RESULT	1	PubMed
28767350	RESULT	1	PubMed

1 to 10 of 63

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005003

GET https://conductscience.org/api/diseases/v1/MONDO_0005003/drugs?page=2

API reference For AI assistants