Drug · CHEMBL12

DIAZEPAM

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. DIAZEPAM. Drugs and targets, record CHEMBL12. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL12

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Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: DIAZEPAM; ChEMBL
ChEMBL ID: CHEMBL12; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Alupram 10, Alupram 2, Alupram 5, Apozepam, Atensine, Dialar, Dialar fte, Diastat, Diastat acudial, Diazepam intensol, Dizac, E-pam, Libervant, Paxel, Q-pam, Relanium, Scriptopam, Serenack, Solis, Stesolid, Tensium, Tranimul, Valclair, Valium, Valrelease, Valtoco, Vivol; ChEMBL
Other names: Ansiolisina, Centrazepam, Diacepin, Diazepam civ, LA III, LA-III, Libervant, NRL-1, NSC-169897, NSC-77518, Nrl-1, RO 5-2807, RO-5-2807, RO-52807, Servizepam, Tranquase, WY-3467; ChEMBL
DrugBank: DB00829; DrugBank
InChIKey: AAOVKJBEBIDNHE-UHFFFAOYSA-N; ChEMBL
Open Targets' highest stage: Approval, for 6 of its 29 diseases, from ATC, DailyMed and TTD; Open Targets

Targets16

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
GABRA1	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2554
GABRA2	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2555
GABRA3	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2556
GABRA4	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2557
GABRA5	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2558
GABRA6	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2559
GABRB1	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2560
GABRB2	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2561
GABRB3	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2562
GABRD	GABA-A receptor; anion channel	GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2563

1 to 10 of 16Source ChEMBL

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Diseases29

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
epilepsy	Approval	DailyMed and TTD	18	12	https://conductscience.org/library/drugs?q=MONDO_0005027
Pain	Phase 2	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=HP_0012531
alcohol withdrawal	Unknown	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=MONDO_0005433
status epilepticus	Phase 3	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=EFO_0008526
anxiety	Approval	ATC	3	2	https://conductscience.org/library/drugs?q=MONDO_0011918
Seizure	Phase 3	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=HP_0001250
Abdominal pain	Phase 2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=HP_0002027
Back pain	Unknown	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=HP_0003418
Coma	Unknown	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=HP_0001259
Febrile seizure (within the age range of 3 months to 6 years)	Unknown	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=HP_0002373

1 to 10 of 29Source Open Targets

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Trials80

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 1 more that Open Targets linked to it is not shown, since the release's checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT00326612	Intranasal Midazolam Versus Rectal Diazepam for Treatment of Seizures	Phase 2	358	2011-10-26	diazepam	Its name	ClinicalTrials.gov
NCT00319501	Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures.	Phase 3	234	2016-08-16	diazepam	Its name	ClinicalTrials.gov
NCT02721069	Repeat Dose Safety Study of NRL-1 in Epilepsy Subjects	Phase 3	175	2022-01-31	nrl-1	Its name	ClinicalTrials.gov
NCT02494180	A Non-inferiority Trial on Pain Relief During Oocyte Retrieval	Phase 4	170	2019-03-05	diazepam	Its name	ClinicalTrials.gov
NCT03428360	Safety and Tolerability Study of Diazepam Buccal Film (DBF) in Subjects With Epilepsy	Phase 3	149	2021-08-05	diazepam	Its name	ClinicalTrials.gov
NCT02316847	An Open-Label, Safety and Tolerability Study of Chronic Intermittent Use of Diazepam Nasal Spray.	Phase 2	126	2018-07-30	diazepam	Its name	ClinicalTrials.gov
NCT02646124	Diazepam Use With Standard Management for Acute Low Back Pain	Phase 2/3	114	2018-07-03	diazepam	Its name	ClinicalTrials.gov
NCT03818932	Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction	Phase 2/3	90	2026-03-19	diazepam	Its name	ClinicalTrials.gov
NCT06103188	Comparing the Effect of Melatonin, Diazepam, and Placebo on Decreasing the Level of Anxiety Preoperatively	Phase 3	87	2025-01-24	diazepam	Its name	ClinicalTrials.gov
NCT02474407	Bioavailability, Safety and Tolerability of Diazepam Nasal Spray Versus Diazepam Rectal Gel (Diastat®)	Phase 2	78	2018-10-16	diazepam	Its name	ClinicalTrials.gov

1 to 10 of 80

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Comparisons in its trials37

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
A: Intravenous Fentanyl, Midazolam vs B: Intravenous Pethidine, Diazepam: deaths from any cause	0 of 85	0 of 85	170	NCT02494180	Trial comparisons
A: Intravenous Fentanyl, Midazolam vs B: Intravenous Pethidine, Diazepam: serious adverse events	0 of 85	0 of 85	170	NCT02494180	Trial comparisons
Diazepam vs Placebo: Number of Participants Requiring Rescue Medication During the Double-blind Period	14 of 82	24 of 81	163	NCT00319501	Trial comparisons
Diazepam vs Placebo: Number of Participants Requiring Rescue Medical Care Other Than Rescue Medication or Emergency Department Visits During the Double-blind Period	0 of 82	2 of 81	163	NCT00319501	Trial comparisons
Diazepam vs Placebo: Number of Participants Requiring Emergency Department Visits During the Double-blind Period	2 of 82	4 of 81	163	NCT00319501	Trial comparisons
Diazepam Nasal Spray vs Diazepam Rectal Gel: deaths from any cause	0 of 78	0 of 78	156	NCT02474407	Trial comparisons
Diazepam Nasal Spray vs Diazepam Rectal Gel: serious adverse events	0 of 78	0 of 78	156	NCT02474407	Trial comparisons
Diazepam vs Placebo: Participants Satisfied With Treatment	44 of 57	37 of 55	112	NCT02646124	Trial comparisons
Diazepam vs Placebo: Number of Participants With Moderate or Severe Pain, as Measured on an Ordinal Scale	18 of 57	12 of 55	112	NCT02646124	Trial comparisons
Diazepam vs Placebo: Number of Participants Who Required Analgesic Medication for Low Back Pain Within the Previous 24 Hours	26 of 57	25 of 55	112	NCT02646124	Trial comparisons

1 to 10 of 37

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Papers from its trials35

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
40650667	RESULT	1	PubMed
28984747	RESULT	1	PubMed
28225210	RESULT	1	PubMed
27994412	RESULT	1	PubMed
25488309	RESULT	1	PubMed
23827090	RESULT	1	PubMed
22786524	RESULT	1	PubMed
19125841	RESULT	1	PubMed
8701843	RESULT	1	PubMed
8510706	RESULT	1	PubMed

1 to 10 of 35

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Tests in its trials1

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

Test	Trials naming it as an outcome	As a primary outcome
Word Stem Completion Task	1	1

Source ConductCognition

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL12

GET https://conductscience.org/api/drugs/v1/CHEMBL12/diseases?page=2

API reference For AI assistants