Disease · MONDO_0005392

scoliosis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. scoliosis. Diseases, record MONDO_0005392. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005392

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: scoliosis; Open Targets
Open Targets ID: MONDO_0005392; Open Targets
Disease Ontology: DOID:0060249; Disease Ontology
MeSH: D012600; MeSH
NCI Thesaurus: C78603; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 1 of its 9 drugs, from ClinicalTrials.gov; Open Targets

Drugs9

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
METHADONE	CHEMBL651	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
DEXMEDETOMIDINE	CHEMBL778	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
PROPOFOL	CHEMBL526	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
REMIFENTANIL	CHEMBL1005	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
TRANEXAMIC ACID	CHEMBL877	Small molecule	Unknown	ClinicalTrials.gov	2	2	2	Drugs and targets
BUPIVACAINE	CHEMBL1098	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
DESMOPRESSIN	CHEMBL1429	Protein	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
EPINEPHRINE	CHEMBL679	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
REMIMAZOLAM	CHEMBL4297526	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets31

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADRA2A	Adrenergic receptor	2	Adrenergic receptor agonist; Adrenergic receptor alpha-2 agonist	Phase 2	https://conductscience.org/library/genes/150	Drugs and targets
ADRA2B	Adrenergic receptor	2	Adrenergic receptor agonist; Adrenergic receptor alpha-2 agonist	Phase 2	https://conductscience.org/library/genes/151	Drugs and targets
ADRA2C	Adrenergic receptor	2	Adrenergic receptor agonist; Adrenergic receptor alpha-2 agonist	Phase 2	https://conductscience.org/library/genes/152	Drugs and targets
GABRA1	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2554	Drugs and targets
GABRA2	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2555	Drugs and targets
GABRA3	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2556	Drugs and targets
GABRA4	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2557	Drugs and targets
GABRA5	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2558	Drugs and targets
GABRA6	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2559	Drugs and targets
GABRB1	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Phase 2	https://conductscience.org/library/genes/2560	Drugs and targets

1 to 10 of 31

See all 31 targets

Trials6

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02558010	Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients	Phase 3	58	2023-04-27	Scoliosis, Pain	METHADONE	Its record names the disease	ClinicalTrials.gov
NCT06096181	Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery	Phase 2	13	2025-11-10	Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil, Dexmedetomidine, Posterior Spinal Fusion	DEXMEDETOMIDINE, PROPOFOL, REMIFENTANIL	Open Targets' reading of its record	ClinicalTrials.gov
NCT05519371	Remimazolam and Scoliosis Orthopedics	Not applicable	148		Benzodiazepines	REMIMAZOLAM	Its record names the disease	ClinicalTrials.gov
NCT02084342	Study of DDAVP Combined With TXA on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery	Not applicable	60		Idiopathic Scoliosis	DESMOPRESSIN, TRANEXAMIC ACID	Its record names the disease	ClinicalTrials.gov
NCT03319563	Kyphoscoliosis Surgery: Blood Conservation and Analgesia	Not applicable	52		Posterior Spine Surgery	BUPIVACAINE, EPINEPHRINE	Its record names the disease	ClinicalTrials.gov
NCT04622397	Local Subfascial and Intramuscular Tranexamic Acid Administration in Pediatric Patient Undergoing Scoliosis Surgery, Double Blind Randomized Control Trial	Not applicable	30		Blood Loss, Surgical, Scoliosis	TRANEXAMIC ACID	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Methadone Group vs Control Group: deaths from any cause	0 of 25	0 of 22	47	NCT02558010	Trial comparisons
Methadone Group vs Control Group: serious adverse events	0 of 25	0 of 22	47	NCT02558010	Trial comparisons
Propofol + Remifentanil vs Propofol + Dexmedetomidine: deaths from any cause	0 of 7	0 of 6	13	NCT06096181	Trial comparisons
Propofol + Remifentanil vs Propofol + Dexmedetomidine: serious adverse events	0 of 7	0 of 6	13	NCT06096181	Trial comparisons

Papers from its trials0

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

None in this release.

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005392

GET https://conductscience.org/api/diseases/v1/MONDO_0005392/targets?page=2

API reference For AI assistants