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Disease · MONDO_0005468

hypotensive disorder

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. hypotensive disorder. Diseases, record MONDO_0005468. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005468

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
hypotensive disorder
Open Targets
Open Targets ID
MONDO_0005468
Open Targets
Other names
Arterial hypotension, Low blood pressure, hypotension, hypotension (disease)
Open Targets
MeSH
D007022
MeSH
Highest stage of its drugs
Approval, for 10 of its 73 drugs, from DailyMed, EMA Human Drugs, FDA and TTD
Open Targets

Drugs73

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
ANGIOTENSIN IICHEMBL408403ProteinApprovalEMA Human Drugs655Drugs and targets
ANGIOTENSIN-IICHEMBL2392353ProteinApprovalEMA Human Drugs433Drugs and targets
METARAMINOLCHEMBL1201319Small moleculeApprovalTTD322Drugs and targets
EPHEDRINE SULFATECHEMBL1523964Small moleculeApprovalDailyMed400Drugs and targets
AMEZINIUMCHEMBL2110922Small moleculeApprovalTTD100Drugs and targets
DOPAMINE HYDROCHLORIDECHEMBL1557Small moleculeApprovalEMA Human Drugs100Drugs and targets
EPHEDRINE HYDROCHLORIDECHEMBL2146102Small moleculeApprovalFDA100Drugs and targets
HEMOGLOBIN CROSFUMARILCHEMBL2108962ApprovalTTD100Drugs and targets
PENTOLINIUMCHEMBL1271Small moleculeApprovalTTD100Drugs and targets
PHENYLEPHRINE HYDROCHLORIDECHEMBL1200339Small moleculeApprovalDailyMed100Drugs and targets

1 to 10 of 73

See all 73 drugs

Targets73

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
ADRA1AAdrenergic receptor13Adrenergic receptor agonist; Adrenergic receptor alpha-1 agonist; Adrenergic receptor antagonistApprovalhttps://conductscience.org/library/genes/148Drugs and targets
ADRA1BAdrenergic receptor13Adrenergic receptor agonist; Adrenergic receptor alpha-1 agonist; Adrenergic receptor antagonistApprovalhttps://conductscience.org/library/genes/147Drugs and targets
ADRA1DAdrenergic receptor13Adrenergic receptor agonist; Adrenergic receptor alpha-1 agonist; Adrenergic receptor antagonistApprovalhttps://conductscience.org/library/genes/146Drugs and targets
ADRB1Adrenergic receptor10Adrenergic receptor agonist; Adrenergic receptor antagonist; Beta-1 adrenergic receptor agonistApprovalhttps://conductscience.org/library/genes/153Drugs and targets
ADRA2AAdrenergic receptor9Adrenergic receptor agonist; Adrenergic receptor alpha-2 agonist; Adrenergic receptor antagonistApprovalhttps://conductscience.org/library/genes/150Drugs and targets
ADRA2BAdrenergic receptor9Adrenergic receptor agonist; Adrenergic receptor alpha-2 agonist; Adrenergic receptor antagonistApprovalhttps://conductscience.org/library/genes/151Drugs and targets
ADRA2CAdrenergic receptor9Adrenergic receptor agonist; Adrenergic receptor alpha-2 agonist; Adrenergic receptor antagonistApprovalhttps://conductscience.org/library/genes/152Drugs and targets
ADRB3Adrenergic receptor9Adrenergic receptor agonist; Adrenergic receptor antagonist; Beta-3 adrenergic receptor agonistApprovalhttps://conductscience.org/library/genes/155Drugs and targets
ADRB2Adrenergic receptor8Adrenergic receptor agonist; Adrenergic receptor antagonistApprovalhttps://conductscience.org/library/genes/154Drugs and targets
GABRA1GABA-A receptor; anion channel6GABA-A receptor; anion channel agonist; GABA-A receptor; anion channel positive allosteric modulator; GABA-A receptor; anion channel positive modulatorPhase 3https://conductscience.org/library/genes/2554Drugs and targets

1 to 10 of 73

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Trials109

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT03434028Crystalloid Liberal or Vasopressors Early Resuscitation in SepsisPhase 31,5632023-07-06Septic ShockNOREPINEPHRINEIts record names the diseaseClinicalTrials.gov
NCT00223704Bradykinin Receptor Antagonism During Cardiopulmonary BypassPhase 2/31502013-10-11Cardiopulmonary Bypass, Inflammation, Fibrinolysis, SurgeryAMINOCAPROIC ACID, BRADYKININIts record names the diseaseClinicalTrials.gov
NCT01531959Midodrine for the Treatment of Refractory HypotensionPhase 31392019-09-06Hypotension, Critical IllnessMIDODRINEIts record names the diseaseClinicalTrials.gov
NCT00458003Phenylephrine in Spinal Anesthesia in Preeclamptic PatientsNot applicable1102022-06-02Preeclampsia, HypotensionEPHEDRINE, PHENYLEPHRINEIts record names the diseaseClinicalTrials.gov
NCT00657046Safety and Benefit Study of Droxidopa to Treat Patients With Intradialytic HypotensionPhase 2852014-06-27Intradialytic HypotensionDROXIDOPAOpen Targets' reading of its recordClinicalTrials.gov
NCT01318278Study of Dopamine Versus Vasopressin for Treatment of Low Blood Pressure in Low Birth Weight InfantsNot applicable702015-03-10HypotensionDOPAMINE, VASOPRESSINIts record names the diseaseClinicalTrials.gov
NCT01841606The Effect of Ondansetron on Cardiac Output in Elective Cesarean DeliveriesPhase 2572018-05-11Cardiac OutputONDANSETRONIts record names the diseaseClinicalTrials.gov
NCT00835224Safety and Efficacy of L-NAME and Midodrine to Increase MAPPhase 2342014-04-23Orthostatic Hypotension, Spinal Cord InjuryMIDODRINE HYDROCHLORIDEIts record names the diseaseClinicalTrials.gov
NCT03733145Angiotensin II in General AnesthesiaPhase 4322025-08-24HypertensionANGIOTENSIN IIIts record names the diseaseClinicalTrials.gov
NCT00248807A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.Not applicable302014-06-23Orthostatic Hypotension, Spinal Cord InjuriesENALAPRILATIts record names the diseaseClinicalTrials.gov

1 to 10 of 109

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Comparisons in its trials22

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Restrictive Fluids vs Liberal Fluids: serious adverse events18 of 78219 of 7811,563NCT03434028Trial comparisons
Restrictive Fluids vs Liberal Fluids: New Onset Atrial or Ventricular Arrhythmia59 of 77967 of 7781,557NCT03434028Trial comparisons
Restrictive Fluids vs Liberal Fluids: Death From Any Cause at Any Location by Day 90172 of 768169 of 7731,541NCT03434028Trial comparisons
Restrictive Fluids vs Liberal Fluids: deaths from any cause172 of 768169 of 7731,541NCT03434028Trial comparisons
Restrictive Fluids vs Liberal Fluids: Development of ARDS19 of 75720 of 7581,515NCT03434028Trial comparisons
Restrictive Fluids vs Liberal Fluids: Initiation of Renal Replacement Therapy24 of 73824 of 7381,476NCT03434028Trial comparisons
Restrictive Fluids vs Liberal Fluids: New Intubation With Invasive Mechanical Ventilation by 28 Days77 of 70187 of 6871,388NCT03434028Trial comparisons
Midodrine vs Placebo: Rates of ICU Readmission1 of 663 of 66132NCT01531959Trial comparisons
Midodrine vs Placebo: deaths from any cause0 of 661 of 66132NCT01531959Trial comparisons
Midodrine vs Placebo: Rates of Hypertension, Bradycardia, and Hemodynamically Significant Tacharrythmias12 of 663 of 66132NCT01531959Trial comparisons

1 to 10 of 22

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Papers from its trials87

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
37462430RESULT1PubMed
36639328RESULT1PubMed
36507525RESULT1PubMed
34916051RESULT1PubMed
34859868RESULT1PubMed
33555690RESULT1PubMed
32677707RESULT1PubMed
32417976RESULT1PubMed
32303884RESULT1PubMed
31939844RESULT1PubMed

1 to 10 of 87

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Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005468

GET https://conductscience.org/api/diseases/v1/MONDO_0005468/drugs?page=2

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