Disease · MONDO_0005593

chronic periodontitis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. chronic periodontitis. Diseases, record MONDO_0005593. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005593

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: chronic periodontitis; Open Targets
Open Targets ID: MONDO_0005593; Open Targets
Other names: Chronic pericementitis (disorder), Chronic periodontitis NOS, chronic pericementitis, chronic periodontitis (disorder), chronic periodontitis NOS (disorder), periodontitis, chronic; Open Targets
MeSH: D055113; MeSH
NCI Thesaurus: C35326; NCI Thesaurus
Highest stage of its drugs: Approval, for 1 of its 29 drugs, from TTD; Open Targets

Drugs29

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DOXYCYCLINE	CHEMBL1200699	Small molecule	Approval	TTD	1	0	0	Drugs and targets
METRONIDAZOLE	CHEMBL137	Small molecule	Phase 3	ClinicalTrials.gov	6	6	6	Drugs and targets
AMOXICILLIN	CHEMBL1082	Small molecule	Phase 3	ClinicalTrials.gov	5	5	5	Drugs and targets
POTASSIUM NITRATE	CHEMBL1644029	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
SODIUM FLUORIDE	CHEMBL1528	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
TETRACYCLINE	CHEMBL1440	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
OMEGA-3 FATTY ACIDS	CHEMBL4298065		Phase 2/3	ClinicalTrials.gov	3	3	2	Drugs and targets
ASPIRIN	CHEMBL25	Small molecule	Phase 2/3	ClinicalTrials.gov	2	2	2	Drugs and targets
IBUPROFEN	CHEMBL521	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
CHLORHEXIDINE	CHEMBL790	Small molecule	Phase 2	ClinicalTrials.gov	4	4	4	Drugs and targets

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See all 29 drugs

Targets63

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
CHRNA4	Neuronal acetylcholine receptor; alpha4/beta2	2	Neuronal acetylcholine receptor; alpha4/beta2 agonist; Neuronal acetylcholine receptor; alpha4/beta2 partial agonist	Unknown	https://conductscience.org/library/genes/1137	Drugs and targets
CHRNB2	Neuronal acetylcholine receptor; alpha4/beta2	2	Neuronal acetylcholine receptor; alpha4/beta2 agonist; Neuronal acetylcholine receptor; alpha4/beta2 partial agonist	Unknown	https://conductscience.org/library/genes/1141	Drugs and targets
PTGS1	Cyclooxygenase	2	Cyclooxygenase inhibitor	Phase 2/3	https://conductscience.org/library/genes/5742	Drugs and targets
PTGS2	Cyclooxygenase	2	Cyclooxygenase inhibitor	Phase 2/3	https://conductscience.org/library/genes/5743	Drugs and targets
COXFA4	Mitochondrial complex I (NADH dehydrogenase)	1	Mitochondrial complex I (NADH dehydrogenase) inhibitor	Phase 2	https://conductscience.org/library/genes/4697	Drugs and targets
COXFA4L2	Mitochondrial complex I (NADH dehydrogenase)	1	Mitochondrial complex I (NADH dehydrogenase) inhibitor	Phase 2	https://conductscience.org/library/genes/56901	Drugs and targets
GPD2	Glycerol-3-phosphate dehydrogenase, mitochondrial	1	Mitochondrial glycerol-3-phosphate dehydrogenase inhibitor	Phase 2	https://conductscience.org/library/genes/2820	Drugs and targets
HMGCR	3-hydroxy-3-methylglutaryl-coenzyme A reductase	1	HMG-CoA reductase inhibitor	Phase 2	https://conductscience.org/library/genes/3156	Drugs and targets
MMP1	Interstitial collagenase	1	Matrix metalloproteinase-1 inhibitor	Approval	https://conductscience.org/library/genes/4312	Drugs and targets
MMP13	Collagenase 3	1	Matrix metalloproteinase 13 inhibitor	Approval	https://conductscience.org/library/genes/4322	Drugs and targets

1 to 10 of 63

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Trials24

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT03093246	Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis	Phase 2/3	38	2021-07-29	Aggressive Periodontitis	ASPIRIN, OMEGA-3 FATTY ACIDS	Its record names the disease	ClinicalTrials.gov
NCT01568944	Role of Infected Blood Dendritic Cells in Heart Disease Risk	Not applicable	18	2020-05-12	Chronic Periodontitis	AMOXICILLIN, CHLORHEXIDINE, METRONIDAZOLE	Its record names the disease	ClinicalTrials.gov
NCT01098448	Control of Periodontal Infections	Phase 3	187		Periodontitis	AMOXICILLIN, METRONIDAZOLE, TETRACYCLINE	Its record names the disease	ClinicalTrials.gov
NCT02283554	Platelet Rich Fibrin With 1% Metformin Gel for Treatment of Intrabony Defects	Phase 2	120		Periodontitis	METFORMIN	Its record names the disease	ClinicalTrials.gov
NCT05870059	Comparative Evaluation of Propolis Mouthwash With 0.2% Chlorhexidine Mouthwash in Improving the Periodontitis	Phase 2	102		Periodontal Diseases	CHLORHEXIDINE, PROPOLIS WAX	Its record names the disease	ClinicalTrials.gov
NCT01405365	The Impact of Obesity on Nonsurgical Periodontal Therapy	Not applicable	96		Periodontitis, Periodontal Diseases, Obesity	METRONIDAZOLE	Its record names the disease	ClinicalTrials.gov
NCT02120872	Platelet Rich Fibrin Combined With Simvastatin for Treatment of Intrabony Defect in Chronic Periodontitis	Phase 2	90		Three Wall Intrabony Defects in Chronic Periodontitis	SIMVASTATIN	Its record names the disease	ClinicalTrials.gov
NCT06358963	CoQ10 and Omega-3 as Adjuncts to Periodontal Therapy, TAC of Saliva.	Not applicable	80		Periodontal Diseases	OMEGA-3 FATTY ACIDS, UBIDECARENONE	Its record names the disease	ClinicalTrials.gov
NCT02126267	Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection	Not applicable	77		Periodontal Disease, Chronic Periodontitis	AZITHROMYCIN, CHLORHEXIDINE	Its record names the disease	ClinicalTrials.gov
NCT01906450	STUDY ON THE EFFECTS OF PERIODONTAL TREATMENT ALONG WITH THE USE OF ANTIBIOTICS OVER HIGH SENSITIVE C-REACTIVE PROTEIN. RANDOMIZED CONTROLLED CLINICAL TRIAL.	Not applicable	75		Chronic Periodontitis	AZITHROMYCIN	Its record names the disease	ClinicalTrials.gov

1 to 10 of 24

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Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Test Group vs Control Group: deaths from any cause	0 of 19	0 of 19	38	NCT03093246	Trial comparisons
Test Group vs Control Group: serious adverse events	0 of 19	0 of 19	38	NCT03093246	Trial comparisons
Oral Antibiotic and Oral Rinse vs Standard Treatment: deaths from any cause	0 of 8	0 of 8	16	NCT01568944	Trial comparisons
Oral Antibiotic and Oral Rinse vs Standard Treatment: serious adverse events	0 of 8	0 of 8	16	NCT01568944	Trial comparisons

Papers from its trials25

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
32844406	RESULT	1	PubMed
31994207	RESULT	1	PubMed
31620939	RESULT	1	PubMed
30931588	RESULT	1	PubMed
30663271	RESULT	1	PubMed
29604177	RESULT	1	PubMed
29364340	RESULT	1	PubMed
28678975	RESULT	1	PubMed
28303587	RESULT	1	PubMed
26944407	RESULT	1	PubMed

1 to 10 of 25

See all 25 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005593

GET https://conductscience.org/api/diseases/v1/MONDO_0005593/drugs?page=2

API reference For AI assistants