Disease · MONDO_0005607

chronic bronchitis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. chronic bronchitis. Diseases, record MONDO_0005607. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005607

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: chronic bronchitis; Open Targets
Open Targets ID: MONDO_0005607; Open Targets
Other names: bronchitis, chronic; Open Targets
MeSH: D029481; MeSH
NCI Thesaurus: C26722; NCI Thesaurus
Highest stage of its drugs: Approval, for 31 of its 45 drugs, from DailyMed, FDA, PMDA and TTD; Open Targets

Drugs45

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
ROFLUMILAST	CHEMBL193240	Small molecule	Approval	DailyMed	8	7	7	Drugs and targets
LEVOFLOXACIN	CHEMBL5315124	Small molecule	Approval	DailyMed	4	3	3	Drugs and targets
AZITHROMYCIN	CHEMBL529	Small molecule	Approval	DailyMed	4	2	2	Drugs and targets
CLARITHROMYCIN	CHEMBL1741	Small molecule	Approval	DailyMed	3	1	1	Drugs and targets
CEFACLOR	CHEMBL1201018	Small molecule	Approval	DailyMed	2	1	1	Drugs and targets
CEFUROXIME AXETIL	CHEMBL1095930	Small molecule	Approval	DailyMed	2	1	1	Drugs and targets
FLUTICASONE PROPIONATE	CHEMBL1473	Small molecule	Approval	DailyMed	2	1	1	Drugs and targets
SALMETEROL XINAFOATE	CHEMBL1082607	Small molecule	Approval	DailyMed	2	1	1	Drugs and targets
MOXIFLOXACIN HYDROCHLORIDE	CHEMBL1200735	Small molecule	Approval	DailyMed	18	0	0	Drugs and targets
CEFDINIR	CHEMBL927	Small molecule	Approval	DailyMed	8	0	0	Drugs and targets

1 to 10 of 45

See all 45 drugs

Targets20

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADRB2	Beta-2 adrenergic receptor	7	Beta-2 adrenergic receptor agonist	Approval	https://conductscience.org/library/genes/154	Drugs and targets
CHRM3	Muscarinic acetylcholine receptor M3	6	Muscarinic acetylcholine receptor M3 antagonist	Approval	https://conductscience.org/library/genes/1131	Drugs and targets
NR3C1	Glucocorticoid receptor	3	Glucocorticoid receptor agonist	Approval	https://conductscience.org/library/genes/2908	Drugs and targets
PDE4A	Phosphodiesterase 4	3	Phosphodiesterase 4 inhibitor	Approval	https://conductscience.org/library/genes/5141	Drugs and targets
PDE4B	Phosphodiesterase 4	3	Phosphodiesterase 4 inhibitor	Approval	https://conductscience.org/library/genes/5142	Drugs and targets
PDE4C	Phosphodiesterase 4	3	Phosphodiesterase 4 inhibitor	Approval	https://conductscience.org/library/genes/5143	Drugs and targets
PDE4D	Phosphodiesterase 4	3	Phosphodiesterase 4 inhibitor	Approval	https://conductscience.org/library/genes/5144	Drugs and targets
ADORA1	Adenosine receptor	1	Adenosine receptor antagonist	Approval	https://conductscience.org/library/genes/134	Drugs and targets
ADORA2A	Adenosine receptor	1	Adenosine receptor antagonist	Approval	https://conductscience.org/library/genes/135	Drugs and targets
ADORA2B	Adenosine receptor	1	Adenosine receptor antagonist	Approval	https://conductscience.org/library/genes/136	Drugs and targets

1 to 10 of 20

See all 20 targets

Trials27

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02850978	Long-term Use of Spiolto Respimat in Japanese Patients With Chronic Obstructive Pulmonary Disease		1,335	2019-12-06	Pulmonary Disease, Chronic Obstructive	TIOTROPIUM	Its record names the disease	ClinicalTrials.gov
NCT01354938	Outcome Study to Evaluate Klaricid XL® (Clarithromycin Modified Release) in Patients With Acute Exacerbation of Chronic Bronchitis		220	2013-01-30	Bronchitis	CLARITHROMYCIN	Its record names the disease	ClinicalTrials.gov
NCT01509677	Trial to Assess the Anti-inflammatory Effects of Roflumilast in Chronic Obstructive Pulmonary Disease	Phase 3	158	2019-11-29	COPD, Chronic Obstructive Pulmonary Disease	ROFLUMILAST	Its record names the disease	ClinicalTrials.gov
NCT04631016	A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis	Phase 2	137	2025-02-27	Chronic Obstructive Pulmonary Disease (COPD), Chronic Bronchitis	TOZORAKIMAB	Its record names the disease	ClinicalTrials.gov
NCT04441788	A Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Participants With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis (CB)	Phase 2	60	2022-12-20	Chronic Bronchitis, Chronic Obstructive Pulmonary Disease	COFIRASERSEN	Its record names the disease	ClinicalTrials.gov
NCT01739790	N-Acetylcysteine for Patients With COPD and Chronic Bronchitis	Not applicable	51	2017-09-13	COPD, Chronic Bronchitis	ACETYLCYSTEINE	Its record names the disease	ClinicalTrials.gov
NCT03085485	The Topic Trial - Study to Determine the Safety and Efficacy of Ivacaftor	Phase 2	40	2023-12-21	Chronic Obstructive Pulmonary Disease, Chronic Bronchitis	IVACAFTOR	Its record names the disease	ClinicalTrials.gov
NCT01572948	A Placebo-controlled Trial of Daliresp on Chronic Obstructive Pulmonary Disease (COPD)	Not applicable	27	2015-07-31	COPD	ROFLUMILAST	Its record names the disease	ClinicalTrials.gov
NCT01745848	Roflumilast on Markers of Bone Metabolism and Endothelial Function in COPD	Phase 4	26	2017-08-29	Chronic Obstructive Pulmonary Disease	ROFLUMILAST	Its record names the disease	ClinicalTrials.gov
NCT03073798	The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis	Phase 4	12	2017-07-27	COPD, Chronic Bronchitis, Emphysema	ROFLUMILAST	Its record names the disease	ClinicalTrials.gov

1 to 10 of 27

See all 27 trials

Comparisons in its trials16

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
R500 vs Placebo: serious adverse events	8 of 79	5 of 79	158	NCT01509677	Trial comparisons
Tozorakimab vs Placebo: Number of Participants With Abnormal Electrocardiograms (ECGs) Reported as TEAEs	1 of 67	0 of 68	135	NCT04631016	Trial comparisons
Tozorakimab vs Placebo: Number of Participants Experiencing First Chronic Obstructive Pulmonary Disease Composite Exacerbations (COPDCompEx) Event	28 of 67	36 of 68	135	NCT04631016	Trial comparisons
Tozorakimab vs Placebo: deaths from any cause	0 of 67	0 of 68	135	NCT04631016	Trial comparisons
Tozorakimab vs Placebo: serious adverse events	14 of 67	9 of 68	135	NCT04631016	Trial comparisons
N-Acetylcysteine vs Placebo: deaths from any cause	0 of 23	0 of 22	45	NCT01739790	Trial comparisons
N-Acetylcysteine vs Placebo: serious adverse events	3 of 23	2 of 22	45	NCT01739790	Trial comparisons
Ivacaftor vs Placebo: Safety of Ivacaftor - Number of Participants With Abnormal Serum Chemistry	0 of 29	0 of 10	39	NCT03085485	Trial comparisons
Ivacaftor vs Placebo: Safety of Ivacaftor - Number of Participants With Abnormal Hematology	0 of 29	0 of 10	39	NCT03085485	Trial comparisons
Ivacaftor vs Placebo: deaths from any cause	19 of 29	6 of 10	39	NCT03085485	Trial comparisons

1 to 10 of 16

See all 16 comparisons in its trials

Papers from its trials8

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
27143871	RESULT	1	PubMed
17290043	RESULT	1	PubMed
39316773	DERIVED	1	PubMed
35948844	DERIVED	1	PubMed
30224319	DERIVED	1	PubMed
26151090	DERIVED	1	PubMed
23246078	DERIVED	1	PubMed
22300528	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005607

GET https://conductscience.org/api/diseases/v1/MONDO_0005607/drugs?page=2

API reference For AI assistants