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Disease · MONDO_0005709

common cold

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. common cold. Diseases, record MONDO_0005709. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005709

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
common cold
Open Targets
Open Targets ID
MONDO_0005709
Open Targets
Other names
Acute viral rhinopharyngitis, Nasopharyngitis - acute, acute coryza, acute nasopharyngitis, acute nasopharyngitis [common cold], acute rhinitis, rhino-sinusitis
Open Targets
Disease Ontology
DOID:10459
Disease Ontology
MeSH
D003139
MeSH
NCI Thesaurus
C34500
NCI Thesaurus
Highest stage of its drugs
Approval, for 27 of its 49 drugs, from DailyMed and TTD
Open Targets

Drugs49

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
ACETAMINOPHENCHEMBL112Small moleculeApprovalDailyMed6444Drugs and targets
PHENYLEPHRINE HYDROCHLORIDECHEMBL1200339Small moleculeApprovalDailyMed9322Drugs and targets
ASPIRINCHEMBL25Small moleculeApprovalDailyMed422Drugs and targets
PSEUDOEPHEDRINECHEMBL1590Small moleculeApprovalDailyMed322Drugs and targets
GUAIFENESINCHEMBL980Small moleculeApprovalDailyMed4411Drugs and targets
CHLORPHENIRAMINE MALEATECHEMBL1659Small moleculeApprovalDailyMed2411Drugs and targets
IBUPROFENCHEMBL521Small moleculeApprovalDailyMed911Drugs and targets
DEXTROMETHORPHAN HYDROBROMIDECHEMBL1256818Small moleculeApprovalDailyMed9400Drugs and targets
PSEUDOEPHEDRINE HYDROCHLORIDECHEMBL1200724Small moleculeApprovalDailyMed3400Drugs and targets
DIPHENHYDRAMINE HYDROCHLORIDECHEMBL1620Small moleculeApprovalDailyMed1800Drugs and targets

1 to 10 of 49

See all 49 drugs

Targets28

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
HRH1Histamine H1 receptor13Histamine H1 receptor antagonistApprovalhttps://conductscience.org/library/genes/3269Drugs and targets
ADRA1AAdrenergic receptor7Adrenergic receptor agonist; Adrenergic receptor alpha agonist; Adrenergic receptor alpha-1 agonistApprovalhttps://conductscience.org/library/genes/148Drugs and targets
ADRA1BAdrenergic receptor7Adrenergic receptor agonist; Adrenergic receptor alpha agonist; Adrenergic receptor alpha-1 agonistApprovalhttps://conductscience.org/library/genes/147Drugs and targets
ADRA1DAdrenergic receptor7Adrenergic receptor agonist; Adrenergic receptor alpha agonist; Adrenergic receptor alpha-1 agonistApprovalhttps://conductscience.org/library/genes/146Drugs and targets
ADRA2AAdrenergic receptor5Adrenergic receptor agonist; Adrenergic receptor alpha agonist; Adrenergic receptor alpha-2 agonistApprovalhttps://conductscience.org/library/genes/150Drugs and targets
ADRA2BAdrenergic receptor5Adrenergic receptor agonist; Adrenergic receptor alpha agonist; Adrenergic receptor alpha-2 agonistApprovalhttps://conductscience.org/library/genes/151Drugs and targets
ADRA2CAdrenergic receptor5Adrenergic receptor agonist; Adrenergic receptor alpha agonist; Adrenergic receptor alpha-2 agonistApprovalhttps://conductscience.org/library/genes/152Drugs and targets
PTGS1Cyclooxygenase4Cyclooxygenase inhibitorApprovalhttps://conductscience.org/library/genes/5742Drugs and targets
PTGS2Cyclooxygenase4Cyclooxygenase inhibitorApprovalhttps://conductscience.org/library/genes/5743Drugs and targets
SLC6A2Sodium-dependent noradrenaline transporter2Norepinephrine transporter releasing agentApprovalhttps://conductscience.org/library/genes/6530Drugs and targets

1 to 10 of 28

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Trials22

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT01686646Effects of Two Doses of a Common Cold Treatment on AlertnessPhase 32402014-07-14Common ColdACETAMINOPHEN, CAFFEINEIts record names the diseaseClinicalTrials.gov
NCT01277081Effect of Paracetamol on the Common ColdPhase 22002015-02-18Common ColdACETAMINOPHENIts record names the diseaseClinicalTrials.gov
NCT03005067To Evaluate the Efficacy and Safety of 1146A Nasal Spray in Adult Participants With Symptoms of Common ColdPhase 21712018-06-19Common ColdCARBOMER 940Its record names the diseaseClinicalTrials.gov
NCT01883440Glucose Oxidase as Treatment Against Common ColdPhase 2902016-01-27Common ColdDEXTROSE, GLUCOSE OXIDASEIts record names the diseaseClinicalTrials.gov
NCT02379637Study to Evaluate the Efficacy of N-acetylcysteine (NAC) in the Treatment of the Common Cold and CoughPhase 2702016-07-11Common Cold Associated With CoughACETYLCYSTEINEIts record names the diseaseClinicalTrials.gov
NCT01312038Effect of Simethicone on Eustachian Tube DysfunctionPhase 2252016-06-27Otitis MediaSIMETHICONEIts record names the diseaseClinicalTrials.gov
NCT03979209Potential for Cortisol Suppression With the Use of High Volume Nasal Mometasone Irrigations in Varying Dosages.Phase 1162024-08-12Chronic Rhinosinusitis (Diagnosis)MOMETASONEOpen Targets' reading of its recordClinicalTrials.gov
NCT04126304Mycoplasma Infection Rate and Macrolides Resistance in Children With Acute Respiratory Tract Infection2,312Respiratory Tract InfectionsAZITHROMYCINIts record names the diseaseClinicalTrials.gov
NCT00751075Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Phase 3 Study)(Study P02692)Phase 3981Acute RhinosinusitisAMOXICILLIN, MOMETASONE FUROATEOpen Targets' reading of its recordClinicalTrials.gov
NCT01033526Symptomatic Treatment of Common Cold SymptomsPhase 4388Common ColdASPIRINIts record names the diseaseClinicalTrials.gov

1 to 10 of 22

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Comparisons in its trials9

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Mentholated Paracetamol Hot Drink vs Paracetamol Tablets: serious adverse events0 of 1000 of 100200NCT01277081Trial comparisons
Test Product vs Placebo Nasal Spray: deaths from any cause0 of 870 of 81168NCT03005067Trial comparisons
Test Product vs Placebo Nasal Spray: serious adverse events1 of 870 of 81168NCT03005067Trial comparisons
Saline+Glucose vs Glucose Oxidase + Glucose: serious adverse events0 of 450 of 4590NCT01883440Trial comparisons
A N-acetylcysteine vs B Placebo: Safety of Daily Dose of NAC (Number of Patients With Adverse Advents)4 of 354 of 3570NCT02379637Trial comparisons
A N-acetylcysteine vs B Placebo: serious adverse events0 of 350 of 3570NCT02379637Trial comparisons
Simethicone vs Placebo: serious adverse events0 of 130 of 1225NCT01312038Trial comparisons
Mometasone 1mg vs Mometasone 2mg: deaths from any cause0 of 20 of 1416NCT03979209Trial comparisons
Mometasone 1mg vs Mometasone 2mg: serious adverse events0 of 20 of 1416NCT03979209Trial comparisons

Papers from its trials18

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
30697421RESULT1PubMed
29698412RESULT1PubMed
29491245RESULT1PubMed
29268385RESULT1PubMed
28690643RESULT1PubMed
28592978RESULT1PubMed
27293852RESULT1PubMed
26613689RESULT1PubMed
24626238RESULT1PubMed
23716043RESULT1PubMed

1 to 10 of 18

See all 18 papers from its trials

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005709

GET https://conductscience.org/api/diseases/v1/MONDO_0005709/drugs?page=2

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