Disease · MONDO_0006763

frozen shoulder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. frozen shoulder. Diseases, record MONDO_0006763. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0006763

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: frozen shoulder; Open Targets
Open Targets ID: MONDO_0006763; Open Targets
Other names: Bursitis, adhesions-capsulitis,shoulder, adhesive capsulitis, adhesive capsulitis of shoulder; Open Targets
Disease Ontology: DOID:14188; Disease Ontology
Highest stage of its drugs: Approval, for 12 of its 38 drugs, from DailyMed and FDA; Open Targets

Drugs38

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
METHYLPREDNISOLONE	CHEMBL650	Small molecule	Approval	DailyMed	29	8	3	Drugs and targets
DEXAMETHASONE	CHEMBL384467	Small molecule	Approval	DailyMed	7	5	0	Drugs and targets
PREDNISOLONE	CHEMBL131	Small molecule	Approval	DailyMed	6	5	0	Drugs and targets
PREDNISONE	CHEMBL635	Small molecule	Approval	DailyMed	6	5	0	Drugs and targets
METHYLPREDNISOLONE ACETATE	CHEMBL1364144	Small molecule	Approval	DailyMed	7	4	0	Drugs and targets
LIDOCAINE	CHEMBL79	Small molecule	Approval	DailyMed	6	4	2	Drugs and targets
CORTISONE ACETATE	CHEMBL1650	Small molecule	Approval	DailyMed	2	0	0	Drugs and targets
DEXAMETHASONE SODIUM PHOSPHATE	CHEMBL2021430	Small molecule	Approval	DailyMed	2	0	0	Drugs and targets
MENTHOL	CHEMBL256087	Small molecule	Approval	DailyMed	2	0	0	Drugs and targets
CAPSAICIN	CHEMBL294199	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets

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Targets46

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	14	Glucocorticoid receptor agonist	Approval	https://conductscience.org/library/genes/2908	Drugs and targets
PTGS2	Cyclooxygenase	7	Cyclooxygenase inhibitor; Cyclooxygenase-2 inhibitor	Approval	https://conductscience.org/library/genes/5743	Drugs and targets
PTGS1	Cyclooxygenase	4	Cyclooxygenase inhibitor	Approval	https://conductscience.org/library/genes/5742	Drugs and targets
SCN4A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Approval	https://conductscience.org/library/genes/6329	Drugs and targets
SCN10A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker	Approval	https://conductscience.org/library/genes/6336	Drugs and targets
SCN11A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker	Approval	https://conductscience.org/library/genes/11280	Drugs and targets
SCN1A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker	Approval	https://conductscience.org/library/genes/6323	Drugs and targets
SCN2A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker	Approval	https://conductscience.org/library/genes/6326	Drugs and targets
SCN3A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker	Approval	https://conductscience.org/library/genes/6328	Drugs and targets
SCN5A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker	Approval	https://conductscience.org/library/genes/6331	Drugs and targets

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Trials36

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 5 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02006719	Clinical Study for the Treatment of Adhesive Capsulitis of the Shoulder	Phase 2	322	2017-05-25	Adhesive Capsulitis, Frozen Shoulder	COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	Its record names the disease	ClinicalTrials.gov
NCT01483963	AA4500 for the Treatment of Adhesive Capsulitis of the Shoulder	Phase 2	50	2017-05-25	Adhesive Capsulitis, Frozen Shoulder	COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	Its record names the disease	ClinicalTrials.gov
NCT04160091	Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis	Phase 2	19	2021-11-30	Osteoarthritis of the Shoulder, Adhesive Capsulitis	TRIAMCINOLONE ACETONIDE	Its record names the disease	ClinicalTrials.gov
NCT05299242	The Anti-Freaze-F Study- "Anti-TNF for Treatment of Frozen Shoulder - a Feasibility Study"	Phase 2/3	9	2025-01-27	Frozen Shoulder	ADALIMUMAB	Its record names the disease	ClinicalTrials.gov
NCT00377624	HUPS: Hyalgan Use in Painful Shoulder	Phase 3	602		Osteoarthritis of Shoulder	HYALURONATE SODIUM	Its record names the disease	ClinicalTrials.gov
NCT02283996	Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment	Phase 4	260		Adhesive Capsulitis, Frozen Shoulder, Shoulder Frozen	METHYLPREDNISOLONE	Its record names the disease	ClinicalTrials.gov
NCT01983527	Corticosteroids and / or Arthrographic Distention in the Treatment of Adhesive Capsulitis	Not applicable	132		Adhesive Capsulitis, Frozen Shoulder	METHYLPREDNISOLONE	Its record names the disease	ClinicalTrials.gov
NCT00840229	Rotator Interval and Intra-articular Corticosteroid Injection for Frozen Shoulder	Not applicable	122		Adhesive Capsulitis	TRIAMCINOLONE HEXACETONIDE	Its record names the disease	ClinicalTrials.gov
NCT01570985	Treatment Study of Frozen Shoulder: Corticosteroid Injection in Joint Versus Wait and See Policy	Phase 3	120		Shoulder Capsulitis, Shoulder Adhesive Capsulitis, Frozen Shoulder	TRIAMCINOLONE ACETONIDE	Its record names the disease	ClinicalTrials.gov
NCT07493226	Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis	Not applicable	120		Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain, NSAID (Non-Steroidal Anti-Inflammatory Drug), Nociplastic Pain, Neuropathic Pain	DICLOFENAC, ETODOLAC, INDOMETHACIN, MELOXICAM	Its record names the disease	ClinicalTrials.gov

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Comparisons in its trials3

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
AA4500 vs Placebo: serious adverse events	4 of 237	1 of 84	321	NCT02006719	Trial comparisons
Adalimumab vs Placebo: deaths from any cause	0 of 4	0 of 5	9	NCT05299242	Trial comparisons
Adalimumab vs Placebo: serious adverse events	0 of 4	0 of 5	9	NCT05299242	Trial comparisons

Papers from its trials21

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
39353107	RESULT	1	PubMed
35241100	RESULT	1	PubMed
32313809	RESULT	1	PubMed
32117540	RESULT	1	PubMed
30632986	RESULT	1	PubMed
29992159	RESULT	1	PubMed
29417082	RESULT	1	PubMed
29129609	RESULT	1	PubMed
28002160	RESULT	1	PubMed
26873038	RESULT	1	PubMed

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0006763

GET https://conductscience.org/api/diseases/v1/MONDO_0006763/drugs?page=2

API reference For AI assistants