Disease · MONDO_0007028

rotator cuff syndrome

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. rotator cuff syndrome. Diseases, record MONDO_0007028. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0007028

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: rotator cuff syndrome
Open Targets ID: MONDO_0007028
Other names: rotator cuff injury, rotator cuff tear
Highest stage of its drugs: Phase 3, for 5 of its 36 drugs, from ClinicalTrials.gov

Source Open Targets

Drugs36

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
SODIUM CHLORIDE	CHEMBL1200574	Small molecule	Phase 3	ClinicalTrials.gov	3	3	2	Drugs and targets
DEXAMETHASONE	CHEMBL384467	Small molecule	Phase 3	ClinicalTrials.gov	2	2	1	Drugs and targets
TRANEXAMIC ACID	CHEMBL877	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
TRIAMCINOLONE	CHEMBL1451	Small molecule	Phase 3	ClinicalTrials.gov	2	2	0	Drugs and targets
HYALURONATE SODIUM	CHEMBL4594244		Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
ROPIVACAINE	CHEMBL1077896	Small molecule	Phase 2/3	ClinicalTrials.gov	3	3	3	Drugs and targets
CELECOXIB	CHEMBL118	Small molecule	Phase 2/3	ClinicalTrials.gov	2	2	2	Drugs and targets
ACETAMINOPHEN	CHEMBL112	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
DIAZEPAM	CHEMBL12	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
GABAPENTIN	CHEMBL940	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets

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Targets78

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	11	Glucocorticoid receptor agonist	Phase 3	https://conductscience.org/library/genes/2908	Drugs and targets
SCN4A	Sodium channel alpha subunit	4	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 2/3	https://conductscience.org/library/genes/6329	Drugs and targets
PTGS2	Cyclooxygenase	3	Cyclooxygenase inhibitor; Cyclooxygenase-2 inhibitor	Phase 2/3	https://conductscience.org/library/genes/5743	Drugs and targets
ADRA2A	Adrenergic receptor	2	Adrenergic receptor agonist; Adrenergic receptor alpha-2 agonist	Early phase 1	https://conductscience.org/library/genes/150	Drugs and targets
ADRA2B	Adrenergic receptor	2	Adrenergic receptor agonist; Adrenergic receptor alpha-2 agonist	Early phase 1	https://conductscience.org/library/genes/151	Drugs and targets
ADRA2C	Adrenergic receptor	2	Adrenergic receptor agonist; Adrenergic receptor alpha-2 agonist	Early phase 1	https://conductscience.org/library/genes/152	Drugs and targets
AR	Androgen receptor	2	Androgen Receptor agonist	Phase 2/3	https://conductscience.org/library/genes/367	Drugs and targets
ESR1	Estrogen receptor	2	Estrogen receptor alpha agonist; Estrogen receptor alpha modulator	Phase 2	https://conductscience.org/library/genes/2099	Drugs and targets
OPRK1	Kappa-type opioid receptor	2	Kappa opioid receptor agonist; Opioid receptors; mu/kappa/delta agonist	Phase 2/3	https://conductscience.org/library/genes/4986	Drugs and targets
OPRM1	Mu-type opioid receptor	2	Mu opioid receptor agonist; Opioid receptors; mu/kappa/delta agonist	Phase 2/3	https://conductscience.org/library/genes/4988	Drugs and targets

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Trials23

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01702233	TRARO (Traumeel® S in Rotator Cuff Syndrome)-Study	Phase 3	175	2016-02-24	Rotator Cuff Syndrome, Shoulder Bursitis	DEXAMETHASONE, SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT01123889	Treatment of the Rotator Cuff Disease With Platelet Rich Plasma Injection	Not applicable	12	2014-02-11	Subacromial Impingement Syndrome, Partial Thickness Rotator Cuff Tear	TRIAMCINOLONE ACETONIDE	Its record names the disease	ClinicalTrials.gov
NCT00377624	HUPS: Hyalgan Use in Painful Shoulder	Phase 3	602		Osteoarthritis of Shoulder	HYALURONATE SODIUM	Its record names the disease	ClinicalTrials.gov
NCT04047745	Post-operative Exparel Study Following Rotator Cuff Repair	Not applicable	132		Rotator Cuff Tears	BUPIVACAINE, ROPIVACAINE	Its record names the disease	ClinicalTrials.gov
NCT03825809	Nonopioid Analgesia After Labral Surgery	Phase 2/3	100		Narcotic Use	ACETAMINOPHEN, CELECOXIB, DIAZEPAM, GABAPENTIN, HYDROCODONE, KETOROLAC	Its record names the disease	ClinicalTrials.gov
NCT05852093	Clinical Study on the Effect of Tizanidine on the Function and Pain of Patients After Shoulder Arthroscopy	Early phase 1	100		Rotator Cuff Tears	BUPRENORPHINE, CELECOXIB, TIZANIDINE	Its record names the disease	ClinicalTrials.gov
NCT04681937	Comparison of Hyaluronic Acid, PRP and Steroid Injections in Partial Rotator Cuff Tears: A Prospective Randomized Study	Not applicable	80		Partial Tear of Rotator Cuff, Rotator Cuff Tears	HYALURONIC ACID, METHYLPREDNISOLONE ACETATE	Its record names the disease	ClinicalTrials.gov
NCT05677152	Influence of an Anti-osteoporotic Drug on Healing After Surgical Repair of Chronic Rotator Cuff Lesions of the Shoulder	Phase 2	80		Orthopedics, Traumatology	ZOLEDRONIC ACID	Its record names the disease	ClinicalTrials.gov
NCT05848375	Rotator Cuff Repair Under Isolated Loco-regional Anesthesia	Not applicable	80		Shoulder Cuff Surgical Repair	LEVOBUPIVACAINE, ROPIVACAINE	Its record names the disease	ClinicalTrials.gov
NCT07442643	Epinephrine-Added Irrigation Versus Intravenous Tranexamic Acid in Arthroscopic Rotator Cuff Repair: A Prospective Randomized Controlled Trial	Not applicable	80		Rotator Cuff Tear	EPINEPHRINE, TRANEXAMIC ACID	Its record names the disease	ClinicalTrials.gov

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Comparisons in its trials1

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial
Experimental vs Control: serious adverse events	0 of 7	0 of 5	12	NCT01123889

Source Trial comparisons

Papers from its trials4

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
42316896	DERIVED	1	PubMed
41549490	DERIVED	1	PubMed
31934594	DERIVED	1	PubMed
25649543	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0007028

GET https://conductscience.org/api/diseases/v1/MONDO_0007028/drugs?page=2

API reference For AI assistants