Disease · MONDO_0019091
bronchopulmonary dysplasia
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. bronchopulmonary dysplasia. Diseases, record MONDO_0019091. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0019091
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
Drugs49
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| PALIVIZUMAB | CHEMBL1201586 | Antibody | Approval | DailyMed | 1 | 0 | 0 | Drugs and targets |
| CAFFEINE CITRATE | CHEMBL1200569 | Small molecule | Phase 3 | ClinicalTrials.gov | 5 | 4 | 4 | Drugs and targets |
| BERACTANT | CHEMBL1201624 | Phase 3 | ClinicalTrials.gov | 4 | 4 | 1 | Drugs and targets | |
| DEXAMETHASONE | CHEMBL384467 | Small molecule | Phase 3 | ClinicalTrials.gov | 4 | 4 | 3 | Drugs and targets |
| AZITHROMYCIN | CHEMBL529 | Small molecule | Phase 3 | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| BETAMETHASONE | CHEMBL632 | Small molecule | Phase 3 | ClinicalTrials.gov | 3 | 3 | 2 | Drugs and targets |
| HYDROCORTISONE | CHEMBL389621 | Small molecule | Phase 3 | ClinicalTrials.gov | 3 | 3 | 2 | Drugs and targets |
| PORACTANT ALFA | CHEMBL1201622 | Phase 3 | ClinicalTrials.gov | 3 | 3 | 2 | Drugs and targets | |
| AUTOLOGOUS CORD BLOOD | CHEMBL4594461 | Phase 3 | ClinicalTrials.gov | 2 | 2 | 1 | Drugs and targets | |
| BUDESONIDE | CHEMBL1370 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
1 to 10 of 49
See all 49 drugsTargets74
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| NR3C1 | Glucocorticoid receptor | 10 | Glucocorticoid receptor agonist | Phase 3 | https://conductscience.org/library/genes/2908 | Drugs and targets |
| PTGS1 | Cyclooxygenase | 3 | Cyclooxygenase inhibitor | Phase 2/3 | https://conductscience.org/library/genes/5742 | Drugs and targets |
| PTGS2 | Cyclooxygenase | 3 | Cyclooxygenase inhibitor | Phase 2/3 | https://conductscience.org/library/genes/5743 | Drugs and targets |
| ADORA1 | Adenosine receptor | 2 | Adenosine receptor antagonist | Phase 3 | https://conductscience.org/library/genes/134 | Drugs and targets |
| ADORA2A | Adenosine receptor | 2 | Adenosine receptor antagonist | Phase 3 | https://conductscience.org/library/genes/135 | Drugs and targets |
| ADORA2B | Adenosine receptor | 2 | Adenosine receptor antagonist | Phase 3 | https://conductscience.org/library/genes/136 | Drugs and targets |
| ADORA3 | Adenosine receptor | 2 | Adenosine receptor antagonist | Phase 3 | https://conductscience.org/library/genes/140 | Drugs and targets |
| ADRB2 | Beta-2 adrenergic receptor | 1 | Beta-2 adrenergic receptor agonist | Unknown | https://conductscience.org/library/genes/154 | Drugs and targets |
| COXFA4 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Early phase 1 | https://conductscience.org/library/genes/4697 | Drugs and targets |
| COXFA4L2 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Early phase 1 | https://conductscience.org/library/genes/56901 | Drugs and targets |
1 to 10 of 74
See all 74 targetsTrials49
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 6 more are not shown, since the checks do not confirm them.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01353313 | Hydrocortisone for BPD | Phase 3 | 800 | 2022-08-19 | Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature, Bronchopulmonary Dysplasia | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov |
| NCT04545866 | The Budesonide in Babies (BiB) Trial | Phase 3 | 642 | 2025-11-10 | Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome, Prematurity; Extreme, Neonatal | BUDESONIDE, PORACTANT ALFA | Its record names the disease | ClinicalTrials.gov |
| NCT01030575 | Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2) | Phase 2 | 125 | 2021-03-12 | Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Retinopathy of Prematurity, Bronchopulmonary Dysplasia (BPD) | INOSITOL | Its record names the disease | ClinicalTrials.gov |
| NCT04447989 | Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia | Phase 2 | 125 | 2026-01-26 | Bronchopulmonary Dysplasia of Newborn | SILDENAFIL | Its record names the disease | ClinicalTrials.gov |
| NCT00955487 | Examining the Use of Non-Invasive Inhaled Nitric Oxide to Reduce Chronic Lung Disease in Premature Newborns | Phase 2 | 124 | 2017-05-23 | Bronchopulmonary Dysplasia | NITRIC OXIDE, NITROGEN | Its record names the disease | ClinicalTrials.gov |
| NCT01778634 | Trial of Intravenous Azithromycin to Eradicate Ureaplasma Respiratory Tract Infection in Preterm Infants | Phase 2 | 121 | 2018-05-17 | Ureaplasma Infections | AZITHROMYCIN | Its record names the disease | ClinicalTrials.gov |
| NCT03142568 | Safety of Sildenafil in Premature Infants | Phase 2 | 109 | 2026-03-11 | Bronchopulmonary Dysplasia | SILDENAFIL | Its record names the disease | ClinicalTrials.gov |
| NCT00802685 | Timing of PDA Closure and Respiratory Outcome in Premature Infants | Not applicable | 105 | 2013-11-28 | Patent Ductus Arteriosus | IBUPROFEN | Its record names the disease | ClinicalTrials.gov |
| NCT01751724 | Caffeine to Reduce Mechanical Ventilation in Preterm Infants | Not applicable | 87 | 2017-06-19 | Prematurity, Apnea, Respiratory Failure | CAFFEINE CITRATE | Its record names the disease | ClinicalTrials.gov |
| NCT02527798 | Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia (BPD) | Phase 2 | 82 | 2021-12-28 | Bronchopulmonary Dysplasia | FUROSEMIDE | Its record names the disease | ClinicalTrials.gov |
1 to 10 of 49
See all 49 trialsComparisons in its trials49
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Hydrocortisone vs Placebo: deaths from any cause | 43 of 398 | 46 of 402 | 800 | NCT01353313 | Trial comparisons |
| Hydrocortisone vs Placebo: serious adverse events | 84 of 398 | 95 of 402 | 800 | NCT01353313 | Trial comparisons |
| BUDE vs SURF: deaths from any cause | 49 of 323 | 42 of 318 | 641 | NCT04545866 | Trial comparisons |
| BUDE vs SURF: serious adverse events | 63 of 323 | 55 of 318 | 641 | NCT04545866 | Trial comparisons |
| Inhaled Nitric Oxide (iNO) vs Placebo (Nitrogen): Necrotizing Enterocolitis (NEC) | 5 of 59 | 10 of 65 | 124 | NCT00955487 | Trial comparisons |
| Inhaled Nitric Oxide (iNO) vs Placebo (Nitrogen): Threshold Retinopathy of Prematurity (ROP) | 3 of 59 | 4 of 65 | 124 | NCT00955487 | Trial comparisons |
| Inhaled Nitric Oxide (iNO) vs Placebo (Nitrogen): Symptomatic PDA Requiring Surgical Ligation | 3 of 59 | 8 of 65 | 124 | NCT00955487 | Trial comparisons |
| Inhaled Nitric Oxide (iNO) vs Placebo (Nitrogen): Severe Intracranial Hemorrhage | 2 of 59 | 4 of 65 | 124 | NCT00955487 | Trial comparisons |
| Inhaled Nitric Oxide (iNO) vs Placebo (Nitrogen): Sepsis | 13 of 59 | 14 of 65 | 124 | NCT00955487 | Trial comparisons |
| Inhaled Nitric Oxide (iNO) vs Placebo (Nitrogen): deaths from any cause | 2 of 59 | 4 of 65 | 124 | NCT00955487 | Trial comparisons |
1 to 10 of 49
See all 49 comparisons in its trialsPapers from its trials42
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0019091
GET https://conductscience.org/api/diseases/v1/MONDO_0019091/drugs?page=2