Disease · MONDO_0021178

injury

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. injury. Diseases, record MONDO_0021178. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0021178

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: injury; Open Targets
Open Targets ID: MONDO_0021178; Open Targets
Other names: trauma, traumatic injury, wound; Open Targets
MeSH: D014947; MeSH
NCI Thesaurus: C3671; NCI Thesaurus
Highest stage of its drugs: Approval, for 12 of its 60 drugs, from DailyMed, FDA, PMDA and TTD; Open Targets

Drugs60

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Source
CARBIDOPA	CHEMBL1200748	Small molecule	Approval	DailyMed	3	Drugs and targets
MENTHOL	CHEMBL256087	Small molecule	Approval	DailyMed	3	Drugs and targets
TRIAMCINOLONE ACETONIDE	CHEMBL1504	Small molecule	Approval	DailyMed	2	Drugs and targets
ACETYLCYSTEINE	CHEMBL600	Small molecule	Approval	DailyMed	1	Drugs and targets
BEREMAGENE GEPERPAVEC	CHEMBL4594328	Gene	Approval	FDA	1	Drugs and targets
CAMPHOR	CHEMBL15768	Small molecule	Approval	DailyMed	1	Drugs and targets
CHLORPHENESIN CARBAMATE	CHEMBL607710	Small molecule	Approval	TTD	1	Drugs and targets
DAPTOMYCIN	CHEMBL387675	Small molecule	Approval	PMDA	1	Drugs and targets
LEVODOPA	CHEMBL1009	Small molecule	Approval	DailyMed	1	Drugs and targets
METHYL SALICYLATE	CHEMBL108545	Small molecule	Approval	DailyMed	1	Drugs and targets

1 to 10 of 60

See all 60 drugs

Targets98

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
PTGS2	Cyclooxygenase	6	Cyclooxygenase inhibitor; Cyclooxygenase-2 inhibitor	Phase 3	https://conductscience.org/library/genes/5743	Drugs and targets
PTGS1	Cyclooxygenase	4	Cyclooxygenase inhibitor	Phase 3	https://conductscience.org/library/genes/5742	Drugs and targets
ADRB1	Beta-1 adrenergic receptor	3	Beta-1 adrenergic receptor antagonist	Phase 2	https://conductscience.org/library/genes/153	Drugs and targets
GABRA1	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator; GABA-A receptor; anion channel positive modulator	Unknown	https://conductscience.org/library/genes/2554	Drugs and targets
GABRA2	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator; GABA-A receptor; anion channel positive modulator	Unknown	https://conductscience.org/library/genes/2555	Drugs and targets
GABRA3	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator; GABA-A receptor; anion channel positive modulator	Unknown	https://conductscience.org/library/genes/2556	Drugs and targets
GABRA4	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator; GABA-A receptor; anion channel positive modulator	Unknown	https://conductscience.org/library/genes/2557	Drugs and targets
GABRA5	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator; GABA-A receptor; anion channel positive modulator	Unknown	https://conductscience.org/library/genes/2558	Drugs and targets
GABRA6	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator; GABA-A receptor; anion channel positive modulator	Unknown	https://conductscience.org/library/genes/2559	Drugs and targets
GABRB1	GABA-A receptor; anion channel	3	GABA-A receptor; anion channel positive allosteric modulator; GABA-A receptor; anion channel positive modulator	Unknown	https://conductscience.org/library/genes/2560	Drugs and targets

1 to 10 of 98

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Trials43

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 5 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT04155203	To Compare the Safety and Efficacy of Perrigo's Product to an FDA Approved Product for the Treatment of Secondarily Infected Traumatic Skin Lesions	Phase 3	657	2022-11-03	Secondarily Infected Traumatic Skin Lesions	MUPIROCIN CALCIUM	Open Targets' reading of its record	ClinicalTrials.gov
NCT01038557	Frozen Red Blood Cell Transfusions in Trauma Patients	Not applicable	254	2020-01-28	Blood Loss, Anemia, Trauma	BLOOD CELLS, RED	Its record names the disease	ClinicalTrials.gov
NCT05081063	Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients	Phase 3	199	2025-08-08	Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury	BLOOD, WHOLE, PLATELETS	Its record names the disease	ClinicalTrials.gov
NCT02535949	Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury	Phase 2	150	2021-08-31	Hemorrhage, Shock, Wounds and Injuries	TRANEXAMIC ACID	Its record names the disease	ClinicalTrials.gov
NCT05026320	A Clinical Trial to Compare Safety and Effectiveness for Relieving Tenderness of 10% Naproxen Gel vs. a 2.32% Diclofenac Diethylamine Gel in the Treatment of Strains and Bruises of the Legs.	Phase 2	76	2025-01-22	Soft Tissue Injury	DICLOFENAC SODIUM, NAPROXEN	Open Targets' reading of its record	ClinicalTrials.gov
NCT01359735	Healing Effects of HP802-247 Versus Antibiotic Ointment in Mohs Micrographic Surgery Patients	Phase 2	8	2017-06-29	Non-melanoma Skin Cancer	BACITRACIN	Its record names the disease	ClinicalTrials.gov
NCT04588311	ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients	Phase 3	2,500		Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries, Penetrating Injury, Blunt Injury, Major Trauma, Multiple Trauma	EPOETIN ALFA	Its record names the disease	ClinicalTrials.gov
NCT01876550	A Study to Evaluate the Safety and Bioequivalence of Mupirocin Calcium Cream, 2% and Bactroban® Cream and Compare Both to a Vehicle in Treatment of Secondarily Infected Traumatic Skin Lesions.	Phase 1	1,902		Secondarily Infected Traumatic Skin Lesions	MUPIROCIN CALCIUM	Open Targets' reading of its record	ClinicalTrials.gov
NCT04684719	Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial	Phase 3	1,020		Hemorrhagic Shock, Traumatic Injury	BLOOD, WHOLE	Its record names the disease	ClinicalTrials.gov
NCT03092817	Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)	Phase 3	520		Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury, HIV, IRIS	DEXAMETHASONE	Open Targets' reading of its record	ClinicalTrials.gov

1 to 10 of 43

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Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Low Titer O+ Whole Blood vs Component Therapy: deaths from any cause	17 of 52	37 of 147	199	NCT05081063	Trial comparisons
Low Titer O+ Whole Blood vs Component Therapy: serious adverse events	0 of 52	0 of 147	199	NCT05081063	Trial comparisons
Low Titer O+ Whole Blood vs Component Therapy: Mortality	4 of 40	13 of 123	163	NCT05081063	Trial comparisons
HP802-247 vs Bacitracin Ointment: serious adverse events	0 of 4	0 of 4	8	NCT01359735	Trial comparisons

Papers from its trials41

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
29799344	RESULT	1	PubMed
27646281	RESULT	1	PubMed
26452709	RESULT	1	PubMed
23188232	RESULT	1	PubMed
23114490	RESULT	1	PubMed
17349504	RESULT	1	PubMed
15851777	RESULT	1	PubMed
10623981	RESULT	1	PubMed
10376632	RESULT	1	PubMed
10319217	RESULT	1	PubMed

1 to 10 of 41

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0021178

GET https://conductscience.org/api/diseases/v1/MONDO_0021178/drugs?page=2

API reference For AI assistants