Disease · MONDO_0043839
Targets35
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
1 to 20 of 35
Download this page as JSON| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| ATP4A | Potassium-transporting ATPase | 3 | Potassium-transporting ATPase inhibitor | Approval | https://conductscience.org/library/genes/495 | Drugs and targets |
| ATP4B | Potassium-transporting ATPase | 3 | Potassium-transporting ATPase inhibitor | Approval | https://conductscience.org/library/genes/496 | Drugs and targets |
| EDNRA | Endothelin receptor, ET-A/ET-B | 2 | Endothelin receptor, ET-A/ET-B antagonist | Phase 3 | https://conductscience.org/library/genes/1909 | Drugs and targets |
| EDNRB | Endothelin receptor, ET-A/ET-B | 2 | Endothelin receptor, ET-A/ET-B antagonist | Phase 3 | https://conductscience.org/library/genes/1910 | Drugs and targets |
| GUCY1A1 | Soluble guanylate cyclase | 2 | Soluble guanylate cyclase activator; Soluble guanylate cyclase positive allosteric modulator | Phase 2 | https://conductscience.org/library/genes/2982 | Drugs and targets |
| GUCY1A2 | Soluble guanylate cyclase | 2 | Soluble guanylate cyclase activator; Soluble guanylate cyclase positive allosteric modulator | Phase 2 | https://conductscience.org/library/genes/2977 | Drugs and targets |
| GUCY1B1 | Soluble guanylate cyclase | 2 | Soluble guanylate cyclase activator; Soluble guanylate cyclase positive allosteric modulator | Phase 2 | https://conductscience.org/library/genes/2983 | Drugs and targets |
| HRH2 | Histamine H2 receptor | 2 | Histamine H2 receptor antagonist | Approval | https://conductscience.org/library/genes/3274 | Drugs and targets |
| CD274 | Programmed cell death 1 ligand 1 | 1 | Programmed cell death 1 ligand 1 inhibitor | Early phase 1 | https://conductscience.org/library/genes/29126 | Drugs and targets |
| COL11A1 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/1301 | Drugs and targets |
| COL11A2 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/1302 | Drugs and targets |
| COL15A1 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/1306 | Drugs and targets |
| COL18A1 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/80781 | Drugs and targets |
| COL1A1 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/1277 | Drugs and targets |
| COL1A2 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/1278 | Drugs and targets |
| COL24A1 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/255631 | Drugs and targets |
| COL27A1 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/85301 | Drugs and targets |
| COL28A1 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/340267 | Drugs and targets |
| COL2A1 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/1280 | Drugs and targets |
| COL3A1 | Collagen | 1 | Collagen hydrolytic enzyme | Approval | https://conductscience.org/library/genes/1281 | Drugs and targets |
diseases-2026-09-18-0.1.0
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0043839/targets