Disease · MONDO_0100192

liver failure

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. liver failure. Diseases, record MONDO_0100192. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0100192

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: liver failure; Open Targets
Open Targets ID: MONDO_0100192; Open Targets
Other names: Hepatic insufficiency, hepatic failure; Open Targets
MeSH: D017093; MeSH
NCI Thesaurus: C26922; NCI Thesaurus
Highest stage of its drugs: Approval, for 2 of its 25 drugs, from DailyMed; Open Targets

Drugs25

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
RIFAXIMIN	CHEMBL1617	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
TOLCAPONE	CHEMBL1324	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
PENTOXIFYLLINE	CHEMBL628	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
METHYLPREDNISOLONE	CHEMBL650	Small molecule	Phase 2/3	ClinicalTrials.gov	3	3	3	Drugs and targets
CITRIC ACID	CHEMBL1261	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	0	Drugs and targets
SILIBININ	CHEMBL9509	Small molecule	Phase 2/3	TTD	1	0	0	Drugs and targets
ACETYLCYSTEINE	CHEMBL600	Small molecule	Phase 2	ClinicalTrials.gov	1	1	0	Drugs and targets
SEBELIPASE ALFA	CHEMBL3039537	Enzyme	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
HEPATOPOIETIN-A	CHEMBL4298081		Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
TACROLIMUS	CHEMBL3989887	Small molecule	Early phase 1	ClinicalTrials.gov	2	2	2	Drugs and targets

1 to 10 of 25

See all 25 drugs

Targets38

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
CSF3R	Granulocyte colony-stimulating factor receptor	3	Granulocyte colony stimulating factor receptor agonist	Unknown	https://conductscience.org/library/genes/1441	Drugs and targets
ADORA2A	Adenosine A2 receptor	1	Adenosine A2 receptor antagonist	Phase 3	https://conductscience.org/library/genes/135	Drugs and targets
ADORA2B	Adenosine A2 receptor	1	Adenosine A2 receptor antagonist	Phase 3	https://conductscience.org/library/genes/136	Drugs and targets
C5	Complement C5	1	Complement C5 inhibitor	Early phase 1	https://conductscience.org/library/genes/727	Drugs and targets
CD80	T-lymphocyte activation antigen CD80	1	T-lymphocyte activation antigen CD80 inhibitor	Unknown	https://conductscience.org/library/genes/941	Drugs and targets
CD86	T-lymphocyte activation antigen CD86	1	T-lymphocyte activation antigen CD86 inhibitor	Unknown	https://conductscience.org/library/genes/942	Drugs and targets
COMT	Catechol O-methyltransferase	1	Catechol O-methyltransferase inhibitor	Approval	https://conductscience.org/library/genes/1312	Drugs and targets
FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	1	FK506-binding protein 1A inhibitor	Early phase 1	https://conductscience.org/library/genes/2280	Drugs and targets
IFNAR1	Interferon alpha/beta receptor	1	Interferon alpha/beta receptor agonist	Unknown	https://conductscience.org/library/genes/3454	Drugs and targets
IFNAR2	Interferon alpha/beta receptor	1	Interferon alpha/beta receptor agonist	Unknown	https://conductscience.org/library/genes/3455	Drugs and targets

1 to 10 of 38

See all 38 targets

Trials12

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 3 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02193867	Clinical Study In Infants With Rapidly Progressive Lysosomal Acid Lipase Deficiency	Phase 2	10	2019-11-18	Lysosomal Acid Lipase Deficiency	SEBELIPASE ALFA	Its record names the disease	ClinicalTrials.gov
NCT00162552	Clinical Trial of Pentoxifylline in Patient With Cirrhosis	Phase 3	342		Cirrhosis, Liver Failure	PENTOXIFYLLINE	Its record names the disease	ClinicalTrials.gov
NCT01997658	Preoperative Glucocorticoid Use in Major Hepatectomy	Phase 2/3	200		Complications	METHYLPREDNISOLONE	Its record names the disease	ClinicalTrials.gov
NCT03563378	Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation	Not applicable	200		Biliary Atresia Intrahepatic Syndromic Form	SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT03957629	Optimized Treatment of Peginterferon Alfa 2a in Treatment Experienced Patients With HBV Related Liver Fibrosis	Not applicable	186		Hepatitis B, Liver Fibrosis	PEGINTERFERON ALFA-2A, TENOFOVIR DISOPROXIL FUMARATE	Its record names the disease	ClinicalTrials.gov
NCT03920618	Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF	Not applicable	150		Hepatitis B, Acute-On-Chronic Liver Failure	ENTECAVIR, TENOFOVIR ALAFENAMIDE, TENOFOVIR DISOPROXIL FUMARATE	Its record names the disease	ClinicalTrials.gov
NCT06307808	Viral Immunity in Solid Organ Transplant Recipients: Monitoring Of The Response To Hepatitis B Booster Vaccination		66		HBV, Kidney Transplantation, Liver Transplantation	BELATACEPT, TACROLIMUS	Its record names the disease	ClinicalTrials.gov
NCT02689245	Randomized Controlled Trial Comparing the Efficacy and Safety of FMT in Hepatitis B Reactivation Leads to Acute on Chronic Liver Failure.	Not applicable	64		Acute on Chronic Liver Failure	TENOFOVIR	Its record names the disease	ClinicalTrials.gov
NCT07085806	To Study Effect of Injection Pentoxifylline on Liver Growth After Major Liver Surgery	Not applicable	60		Liver Regeneration	PENTOXIFYLLINE	Its record names the disease	ClinicalTrials.gov
NCT01726465	Methylprednisolone N Acetylcysteine in Hepatic Resections	Phase 2	50		Ischemic Reperfusion Injury, Insufficiency; Hepatic, Postoperative, Liver Tumour	METHYLPREDNISOLONE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 12

See all 12 trials

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials6

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
22816029	RESULT	1	PubMed
21037437	RESULT	1	PubMed
16537374	RESULT	1	PubMed
39958923	DERIVED	1	PubMed
26446165	DERIVED	1	PubMed
20102716	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0100192

GET https://conductscience.org/api/diseases/v1/MONDO_0100192/drugs?page=2

API reference For AI assistants