Drug · CHEMBL698

TETRACAINE

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. TETRACAINE. Drugs and targets, record CHEMBL698. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL698

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Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: TETRACAINE; ChEMBL
ChEMBL ID: CHEMBL698; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Ametop, Dicaine, Tetracaine component of pliaglis, Tetracaine component of synera; ChEMBL
Other names: Tetracaina; ChEMBL
Other form: TETRACAINE HYDROCHLORIDE, CHEMBL1255654; Drugs and targets
DrugBank: DB09085; DrugBank
InChIKey: GKCBAIGFKIBETG-UHFFFAOYSA-N; ChEMBL
Open Targets' highest stage: Approval, for 3 of its 12 diseases, from ATC and DailyMed; Open Targets

Targets10

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
SCN10A	Sodium channel alpha subunit	Sodium channel alpha subunit blocker	BLOCKER	https://conductscience.org/library/genes/6336
SCN11A	Sodium channel alpha subunit	Sodium channel alpha subunit blocker	BLOCKER	https://conductscience.org/library/genes/11280
SCN1A	Sodium channel alpha subunit	Sodium channel alpha subunit blocker	BLOCKER	https://conductscience.org/library/genes/6323
SCN2A	Sodium channel alpha subunit	Sodium channel alpha subunit blocker	BLOCKER	https://conductscience.org/library/genes/6326
SCN3A	Sodium channel alpha subunit	Sodium channel alpha subunit blocker	BLOCKER	https://conductscience.org/library/genes/6328
SCN4A	Sodium channel alpha subunit	Sodium channel alpha subunit blocker	BLOCKER	https://conductscience.org/library/genes/6329
SCN5A	Sodium channel alpha subunit	Sodium channel alpha subunit blocker	BLOCKER	https://conductscience.org/library/genes/6331
SCN7A	Sodium channel alpha subunit	Sodium channel alpha subunit blocker	BLOCKER	https://conductscience.org/library/genes/6332
SCN8A	Sodium channel alpha subunit	Sodium channel alpha subunit blocker	BLOCKER	https://conductscience.org/library/genes/6334
SCN9A	Sodium channel alpha subunit	Sodium channel alpha subunit blocker	BLOCKER	https://conductscience.org/library/genes/6335

Source ChEMBL

Diseases12

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
Pain	Approval	DailyMed	11	7	https://conductscience.org/library/drugs?q=HP_0012531
cataract	Phase 3	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=MONDO_0005129
shoulder impingement syndrome	Phase 2	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=MONDO_0006968
acute kidney injury	Unknown	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0002492
carpal tunnel syndrome	Phase 2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0007275
myopia	Phase 2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0001384
osteoarthritis	Phase 1/2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0005178
postherpetic neuralgia	Phase 2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0041052
skin reaction	Unknown	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=EFO_0020927
toothache	Early phase 1	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=EFO_0010072

1 to 10 of 12Source Open Targets

See all 12 diseases

Trials71

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 4 more rest on that reading alone and are shown because the trials' posted result groups or NLM's indexing of their papers name the drug. 5 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT02726620	Decision Support for Intraoperative Low Blood Pressure		22,435	2019-05-16	tetracaine	Its name	ClinicalTrials.gov
NCT04685538	Chloroprocaine 3% Gel Eye Drop as Topical Anestheticsin Phacoemulsification.	Phase 3	338	2022-10-27	tetracaine	Its name	ClinicalTrials.gov
NCT02502487	Dorsal Penile Nerve Block for Rigid Cystoscopy in Men		258	2016-07-11	tetracaine	Its name	ClinicalTrials.gov
NCT00267111	Topical Amethocaine Gel for Intramuscular Injection in Term Neonates	Phase 2	110	2012-04-23	amethocaine	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT00530803	The Efficacy of EMLA Cream vs. Synera Patch for Pain Reduction During Venipuncture in Children	Phase 2	100	2018-08-31	tetracaine	Its name	ClinicalTrials.gov
NCT00798018	Effect of Intra-cuff Lidocaine and Tetracaine on Tracheal Tube-induced Emergence Phenomena		100	2009-12-18	tetracaine	Its name	ClinicalTrials.gov
NCT03233737	Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers	Phase 2	75	2019-08-21	tetracaine	Its name	ClinicalTrials.gov
NCT01951820	Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis	Phase 4	64	2016-07-22	pliaglis	Open Targets' reading, confirmed by the trial's result groups	ClinicalTrials.gov
NCT01744197	Synera Venipuncture Pain	Phase 2	61	2016-02-17	tetracaine	Its name	ClinicalTrials.gov
NCT00716443	Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections	Phase 4	51	2010-02-01	tetracaine	Its name	ClinicalTrials.gov

1 to 10 of 71

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Comparisons in its trials39

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Hypotension Decision Support vs Usual Care Group: deaths from any cause	158 of 4,972	534 of 17,463	22,435	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: serious adverse events	541 of 4,972	1,811 of 17,463	22,435	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 50 mmHg for > 20 Minutes	85 of 4,328	304 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Glycopyrrolate	1,257 of 4,328	11,093 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Ephinephrine	409 of 4,328	1,215 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 60 mmHg	3,798 of 4,328	13,779 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 50 mmHg for > 10 Minutes	326 of 4,328	1,159 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Phenylephrine	3,685 of 4,328	12,211 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: In-hospital Mortality	137 of 4,328	487 of 15,624	19,952	NCT02726620	Trial comparisons
Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 55 mmHg	3,045 of 4,328	10,991 of 15,624	19,952	NCT02726620	Trial comparisons

1 to 10 of 39

See all 39 comparisons in its trials

Papers from its trials14

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
27748655	RESULT	1	PubMed
22943969	RESULT	1	PubMed
22793160	RESULT	1	PubMed
20975464	RESULT	1	PubMed
19151049	RESULT	1	PubMed
38489057	DERIVED	1	PubMed
35622535	DERIVED	1	PubMed
35475300	DERIVED	1	PubMed
35100752	DERIVED	1	PubMed
30660443	DERIVED	1	PubMed

1 to 10 of 14

See all 14 papers from its trials

Tests in its trials0

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

None in this release.

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL698

GET https://conductscience.org/api/drugs/v1/CHEMBL698/trials?page=2

API reference For AI assistants