Disease · EFO_0009620

rib fracture

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. rib fracture. Diseases, record EFO_0009620. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0009620

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: rib fracture; Open Targets
Open Targets ID: EFO_0009620; Open Targets
NCI Thesaurus: C34990; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 2 of its 13 drugs, from ClinicalTrials.gov; Open Targets

Drugs13

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DEXMEDETOMIDINE	CHEMBL778	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
PARECOXIB	CHEMBL1206690	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
LIDOCAINE	CHEMBL79	Small molecule	Phase 2	ClinicalTrials.gov	3	3	3	Drugs and targets
ROPIVACAINE	CHEMBL1077896	Small molecule	Phase 1	ClinicalTrials.gov	4	4	4	Drugs and targets
SODIUM CHLORIDE	CHEMBL1200574	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
KETAMINE	CHEMBL742	Small molecule	Early phase 1	ClinicalTrials.gov	2	2	2	Drugs and targets
BUPIVACAINE	CHEMBL1098	Small molecule	Unknown	ClinicalTrials.gov	3	3	3	Drugs and targets
ACETAMINOPHEN	CHEMBL112	Small molecule	Unknown	ClinicalTrials.gov	2	2	2	Drugs and targets
CELECOXIB	CHEMBL118	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
FENTANYL	CHEMBL596	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 13

See all 13 drugs

Targets51

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
PTGS2	Cyclooxygenase	3	Cyclooxygenase inhibitor; Cyclooxygenase-2 inhibitor	Phase 3	https://conductscience.org/library/genes/5743	Drugs and targets
SCN4A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6329	Drugs and targets
OPRM1	Mu-type opioid receptor	2	Mu opioid receptor agonist	Unknown	https://conductscience.org/library/genes/4988	Drugs and targets
SCN10A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6336	Drugs and targets
SCN11A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/11280	Drugs and targets
SCN1A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6323	Drugs and targets
SCN2A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6326	Drugs and targets
SCN3A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6328	Drugs and targets
SCN5A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6331	Drugs and targets
SCN7A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6332	Drugs and targets

1 to 10 of 51

See all 51 targets

Trials11

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02604589	Continuous Intercostal Nerve Blockade for Traumatic Rib Fractures	Not applicable	10	2017-05-12	Rib Fractures	BUPIVACAINE, HYDROMORPHONE HYDROCHLORIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT03595397	Thoracic Epidural Analgesia in Multiple Traumatic Fracture Ribs	Not applicable	60		Thoracic Epidural Analgesia, Fracture Ribs	BUPIVACAINE, FENTANYL, MAGNESIUM SULFATE	Open Targets' reading of its record	ClinicalTrials.gov
NCT04928300	Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs	Phase 3	60		Rib Fractures	DEXMEDETOMIDINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT06299137	Ultrasound Guided Serratus Anterior Plane Block in ED Patients With Rib Fractures	Early phase 1	40		Rib Fractures, Pain Acute, Regional Anesthesia, Opioid Use	ROPIVACAINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT04413799	PVB vs Ketamine/Lidocaine in Rib Fracture Patients	Early phase 1	32		Rib Fractures, Rib Trauma, Rib Fracture Multiple, Pain, Acute	KETAMINE, LIDOCAINE, ROPIVACAINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT03770208	RIB PAIN (Rib Fractures Treated With Parental Analgesia With Infused LidocaiNe)	Not applicable	26		Rib Fracture Multiple, Pain, Chest, Pain, Acute, Respiratory Failure, Thoracic Injuries, Trauma Chest	LIDOCAINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT02749409	Early Parecoxib Usage to Decreases Narcotic Requirement and Length of Stay After Traumatic Rib Fracture	Phase 3	17		Parecoxib, Rib Fractures	PARECOXIB	Its record names the disease	ClinicalTrials.gov
NCT03540095	Erector Spinae Plane (ESP) Versus Paravertebral Nerve (PVB) Blockade for Acute Unilateral Rib Fracture Pain	Not applicable	7		Rib Fractures, Pain, Acute, Thoracic Injuries, Neuropathic Pain, Neuromuscular Blockade, Anesthesia, Local	ACETAMINOPHEN, BUPIVACAINE, CELECOXIB, GABAPENTIN, KETAMINE, ROPIVACAINE	Its record names the disease	ClinicalTrials.gov
NCT03805360	The Erector Spinae Plane Block and Its Effect on Respiratory Status and Pain Management in Rib Fracture Patients	Phase 1	4		Rib Fractures	ROPIVACAINE, SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT02094807	Pain as Indication for Operative Treatment of Traumatic Rib Fractures	Not applicable	0		Trauma, Rib Fractures, Surgery, Pain	ACETAMINOPHEN	Open Targets' reading of its record	ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials2

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
28372691	RESULT	1	PubMed
42159402	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_0009620

GET https://conductscience.org/api/diseases/v1/EFO_0009620/targets?page=2

API reference For AI assistants